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Introducing Platelet-Rich Stroma: Platelet-Rich Plasma (PRP) and Stromal Vascular Fraction (SVF) Combined for the Treatment of Androgenetic Alopecia
Authors:
Stevens HP; private practice in The Hague, Netherlands.
Donners S; Departments of Pathology and Medical Biology, University of Groningen and University Medical Center Groningen, The Netherlands.
de Bruijn J; Medical University of Utrecht, The Netherlands.
Source:
Aesthetic Surgery Journal [Aesthet Surg J] 2018 Mar 15. Date of Electronic Publication: 2018 Mar 15.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Oxford University Press Country of Publication: England NLM ID: 9707469 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-330X (Electronic) Linking ISSN: 1090820X NLM ISO Abbreviation: Aesthet Surg J
Imprint Name(s):
Publication: 2015-: Oxford : Oxford University Press
Original Publication: St. Louis, MO : Mosby-Year Book, c1997-
Abstract:
Background: Androgenetic alopecia (Androgenetic Alopecia) is characterized by miniaturization of the hair follicles gradually causing conversion of terminal hairs into vellus hairs, leading to progressive reduction of the density of hair on the scalp. Approved therapeutic options are limited and show side effects.
Objectives: To evaluate injections of stromal vascular fraction (SVF), which is rich in adipose-derived stromal cells (ASCs) in combination with platelet-rich plasma (PRP) in the upper scalp as a new autologous treatment option for Androgenetic Alopecia.
Methods: Ten male patients (age range, 25-72 years), suffering from Androgenetic Alopecia at stage II to III according to the Norwood-Hamilton scale, have been treated with a single injection of autologous PRS (ACPSVF: combination of PRP and SVF) in the upper scalp. Preinjection and 6 and 12 weeks postinjection changes in hair density were assessed using ultra high-resolution photography (Fotofinder).
Results: Hair density was significantly increased after 6 weeks and 12 weeks postinjection (P = 0.013 and P < 0.001). In hair-to-hair matching analyses, new hair grew from active follicles. Furthermore nonfunctioning hair follicles filled with hyperkeratotic plugs, up to today assumed incapable of forming new hair, proved to grow new hair. No side effects were noted after treatment.
Conclusions: A single treatment of platelet-rich stroma injected in the scalp of patients with Androgenetic Alopecia significantly increased hair density within 6 to 12 weeks. Further research is required to determine the optimal treatment regimen. Preferred options to our opinion include the repetition of PRS or additional treatments with PRP.
Entry Date(s):
Latest Revision: 20180319
Update Code:
20180320
DOI:
10.1093/asj/sjy029
Authors:
Stevens HP; private practice in The Hague, Netherlands.
Donners S; Departments of Pathology and Medical Biology, University of Groningen and University Medical Center Groningen, The Netherlands.
de Bruijn J; Medical University of Utrecht, The Netherlands.
Source:
Aesthetic Surgery Journal [Aesthet Surg J] 2018 Mar 15. Date of Electronic Publication: 2018 Mar 15.
Publication Type:
Journal Article
Language:
English
Journal Info:
Publisher: Oxford University Press Country of Publication: England NLM ID: 9707469 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-330X (Electronic) Linking ISSN: 1090820X NLM ISO Abbreviation: Aesthet Surg J
Imprint Name(s):
Publication: 2015-: Oxford : Oxford University Press
Original Publication: St. Louis, MO : Mosby-Year Book, c1997-
Abstract:
Background: Androgenetic alopecia (Androgenetic Alopecia) is characterized by miniaturization of the hair follicles gradually causing conversion of terminal hairs into vellus hairs, leading to progressive reduction of the density of hair on the scalp. Approved therapeutic options are limited and show side effects.
Objectives: To evaluate injections of stromal vascular fraction (SVF), which is rich in adipose-derived stromal cells (ASCs) in combination with platelet-rich plasma (PRP) in the upper scalp as a new autologous treatment option for Androgenetic Alopecia.
Methods: Ten male patients (age range, 25-72 years), suffering from Androgenetic Alopecia at stage II to III according to the Norwood-Hamilton scale, have been treated with a single injection of autologous PRS (ACPSVF: combination of PRP and SVF) in the upper scalp. Preinjection and 6 and 12 weeks postinjection changes in hair density were assessed using ultra high-resolution photography (Fotofinder).
Results: Hair density was significantly increased after 6 weeks and 12 weeks postinjection (P = 0.013 and P < 0.001). In hair-to-hair matching analyses, new hair grew from active follicles. Furthermore nonfunctioning hair follicles filled with hyperkeratotic plugs, up to today assumed incapable of forming new hair, proved to grow new hair. No side effects were noted after treatment.
Conclusions: A single treatment of platelet-rich stroma injected in the scalp of patients with Androgenetic Alopecia significantly increased hair density within 6 to 12 weeks. Further research is required to determine the optimal treatment regimen. Preferred options to our opinion include the repetition of PRS or additional treatments with PRP.
Entry Date(s):
Latest Revision: 20180319
Update Code:
20180320
DOI:
10.1093/asj/sjy029