See also: http://www.clonemyhair.com/dcforum/DCForumID1/266.html
1. Hello Dr. Lu Zhongfa. Can you please introduce yourself?
My name is Lu Zhongfa.
Department of Dermatology
The Second Affiliated Hospital,
College of Medicine, Zhejiang University,
Hangzhou 310009, China
EDUCATION:
Aug. 1982- July 1985: Medical student of The JingHua Medical College Zhejiang Province, China.
Aug. 1990 - July 1993: Candidate for MD in Department of Dermatology, Xin Qiao Hospital of The Third Military Medical University. Chongqing, China
Aug. 1995 - Aug 1998: Candidate for Ph.D. in Department of Dermatology, Southwest Hospital of the Third Military Medical University. Chongqing, China
Work History:
1 Aug 1985--Aug 1990. Residency, physcian and attending doctor, in Department of internal medicine, JinHua Worker Hospital, ZheJiang Province, P R China.
2 Aug 1993--Aug 1995. Attending doctor in Department of Dermatology, Xin Qiao Hospital of The Third Military Medical University. Chongqing, China
3 Aug 1998¡ªSep 2001. Attending doctor and director, in Department of Dermatology, Xin Qiao Hospital of The Third Military Medical University. Chongqing, China
4 Sep 2001-- Vice professor, in Department of Dermatology, The second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China
RESEARCH EXPERIENCES:
Our major research is on the ability of dermal papillae cells to induce hair follicle regeneration.
In this study, we have adopted cell culture and other techniques to observe the expression of several molecules (such as bFGF, ET-1, SCF) within different passages cultured dermal papillae cells, and the influence of these dermal papillae cells on hair follicle growth and regeneration in organotypic culture and nude mice models of hair follicle regeneration. This is done to provide some experimental evidence of hair regeneration and is aimed for future treatment of alopecia (baldness) using dermal papillae cells by hair transplantation clinics.
PUBLICATIONS:
http://www.clonemyhair.com/dcforum/DCForumID1/285.html
2. What human cells are you using to clone new hair follicles?
Only dermal papilla cells from hair follicles in human trials will be used, but dermal papilla cells and hair follicle epithelial cells are needed in the animal trial.
3. What hair follicles were used as the source of these cells? What part of the body did these hair follicles were from?
Anagen hair follicles from occipital scalp are used.
4. What part of the hair follicle do the epithelial cells that you use in your procedure come from? Is it hair matrix, outer root sheath, bulge etc?
The outer root sheath included bulge is used.
5. Are there any specific in vitro tissue culture requirements for both dermal papillae and hair follicle epithelium cells that you use?
Some cytokines are needed in DMEM medium. The digested hair follicle epithelium cells are directly used.
6. How long can you culture your cells for without loosing hair-forming properties?
6-8 passages or about 2 months.
7. How do you combine epithelial and dermal papillae cells before transplantation? Is is done as one mixture of in form of small pellets?
We can combine epithelial and dermal papillae cells in hair follicle organotypic cultures or in a small pellets. It is done such that the cultured hair papilla cells, dermal sheath cells and fibroblast of human scalp are mixed with the cells of hair follicle epithelium in different ratios, respectively, and then implanted into the subcutis of nude mice.
8. What is the success rate of transplantation?
The success rate is 30-50%, but I am sure it may be higher in human
trial.
9. How many hairs can you generated from one donor hair follicle?
I think that over 100 hairs could be generated from one donor in human trial, but in animal trial less hairs can be generated.
10. Do new hair follicles look normal? Do hey produce normal hair fiber?
Some hair follicles have normal looking fibers. Others look abnormal, like these formed by trichoepithelioma - small benign tumor derived from basal cells in the hair follicle.
11. Is color of the hairs same as the color of the donor hairs?
Yes it is.
12. How long do the new hairs grow for?
New hairs grow for about about 6-8 weeks.
13. If there are any abnormalities in the structure of newly formed hairs, can you please mention them?
Please see above.
14. Are you planning to do human trials? If yes, can you please give us some time frame? Will this be done within 1 year, 2 years, 3 years or more?
If progressed as planned, it will be done within 2 years.
15. Who will be the candidate patients for your trials?
Volunteers with severe androgenetic alopecia and about 40 years old.
16. Will you accept foreign patients willing to try the procedure?
Volunteers are welcome; an individual from Britain has asked to be a volunteer, but we have not begun to do the trial in humans yet.
Thank you.
Thank you,
Lu Zhongfa
"Interview with Dr. Lu Zhongfa" on haircloning!
- Thread starter polster
- Start date
Trent said:
By the time haircloning becomes a comercial application you wouldve have long forgot about this post you made! Comercial viability and approval by the FDA will be at least 10 years away and first generation of this technology will not produce results which you guys hope for... It will take many years if ever to perfect such a technology!
DarklyCharming
Established Member
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Trent said:
I'm there buddy. We're both young and in our twenties so we may see this out. I say we meet up in Palm Beach, Florida or down in Mexico. Somewhere with great weather, lots of booze, and sandy beaches so we can hang around showing off to the ladies.
jimmystanley
Experienced Member
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what was that part about a benign tumor??
G
Guest
Guest
polster said:
What you are forgetting is that it´s cumulative research. Haircloning goes hand in hand with all stemcell research and stemcell research is the most intense field of research - atleast in the medical community. I agree that it´s not coming out in 3 years but to say that it´s atleast 10 years away and the first generation will suck is just being negative.
Remember we are talking about something with huge money generating potential - these things tend to become exploited.
mvpsoft
Experienced Member
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I keep hearing quotes like this on this forum, but this is not accurate. We might pay money for hair cloning, but most people won't. The market for hair cloning technology is dwarfed by the markets for cloning technology in areas such as cancer treatment and the like. Hair treatments are such a small market compared to other markets that drug companies aren't even willing to invest the $$ in testing, seeking FDA approval and marketing better hair loss medications. Propecia was not a huge money-maker, and so drug companies are not investing in additional products, even though it's now well-known how to make a 5ar inhibitor that doesn't infringe Merck's patent.nesta said:
I'm not saying that there won't be hair cloning research, but the idea that there is a huge untapped market, compared to the markets for other cloning technologies and uses, is simply false.
ShatnersRug
Member
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- 0
It's not "cloning." It's just culturing: taking your own cells, making them reproduce in vitro, then putting them back in. It's nothing so complicated as cloning.
Devin The dude
New Member
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if they can clone a sheep they will be able to regrow hair within a few years. keep a positive attitude folks.
if that doesn't work i'll just have to fall back on my 9 inch dong for my confidence with the ladies.
BTW...San Juan PR is a pretty good spot fellas. Tons of beaches, seedy spots, and the PR women love american white boys. I went there year and a half a go and the tang was bountiful.
if that doesn't work i'll just have to fall back on my 9 inch dong for my confidence with the ladies.
BTW...San Juan PR is a pretty good spot fellas. Tons of beaches, seedy spots, and the PR women love american white boys. I went there year and a half a go and the tang was bountiful.
sk8charlie
Member
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Don't get confused
Don't get confused between Hair Cloning (HC) and Hair Multiplication (HM). HC is using stem cells (found in bone marrow, hair cells, embryonic) and triggering them to re-create hair follicles only. The reason why we can clone a sheep from stem cells is because eventually, that is what the stem cell is programmed to do. It's very complicated to understand without a science background, but basically each and every cell, whether it is a stem cell or not has the book of directions to make a whole new you. The beauty of stem cells is that they are NOT programmed or assigned to use a certain chapter of directions to create a certain body part. Regular cells only use/read a certain chapter of the directions it has; it has the whole book, but only uses and only can use certain chapters. Stem cells can be triggered to use all or some of the chapters. That is why it is easier to clone a whole organism, rather than just a specific body part because it is harder to know the certain signals it takes to trigger a cell to become say, a hair cell. Or in otherwords, it is harder to tell the cell to just read or restrict certain chapters of a book than allow it to read the whole book. On the drawback, the newly cloned individual will have less telomeres, and thus age quicker. As we saw with dolly the sheep, the poor sheep had arthritis and other geriatric ailments even though she was very young. Those are some obstacles that stem cell research has yet to fix.
HM, on the other had, is gathering and culturing cells, and then re-inserting these cells back into the scalp. Cells always divide, until they die usually by degredation, when the products it makes becomes corupt and foreign to the body. (Cancer cells are just that, cells that are corupt, they multiply immensly, do not follow any chemical signals, and they produce byproducts that can be toxic to the body. Normally these cells would be tagged as non-self and destroyed, but they are not dude to genetic factors related to the immune system, etc) The beauty of stem cells is that when they divide, one of them stays a stem cell, and the other matures to become say a hair follicle eventually. Therefore, you will always have a resivorie of stem cells. Only certain organs have stem cells, bone marrow and hair cells being most popular. That is why we age, our non stem cells divide less rapidly as we get older, then we see wrinkles etc etc. The decreased ability of cell regeneration (not speaking of stem cells) is AGING... That's it folks, lack of regeration causes impaired organ functioning.
DHT and other hair loss factors strict the bloodflow, nutrients to the cell and thus all cells die stem cell or not. Once a stem cell is dead, it is dead, it will not be able to regereate itself. This is why people who are bald for long periods of time have extreme difficulty with growing hair back from dormant follicles. Because in actuality, their hair folicles are either extremely miniturized, or absent. The blood is the cells way to get food, without blood or with minimal blood, atrophy of the cell results. This is balding my friends. We know DHT is a culprit, but there may be many many factors....
HM will circumvent this phenomenona by insterting cells taht are resistant to DHT and hair loss factors. These hairs stay on our heads for ever due to genetic factors we are not sure of. All we know is that they will be there, and so the cells we take from them, will produce hair that will stay. HM, will use stem cells from these follicles and create new hair cells that will be injected back into the scalp and hopefully be able to manifest into a hair follicle. It is not cloning. In fact, this is what goes on in your body, HM is basically taking it out of the body, and putting the cells back into the body where appropriate. Oh ya, if you inject a hair cell in your head, it will divide into a stem cell and a hair cell. We dont' know why, it just does, it's because hair cells have that special ability to regenerate itself. And the body only keeps a certain amount of stem cells, it's not like a perpetual cycle.. We have less stem cells than hair cells for sure but if a stem cell dies, then it will be replaced etc.
Honeslty my explanation is quite curtailed, it takes a long time to understand biological processes to even fathom how much we DO NOT KNOW about our bodies especially at the cellular level. Honeslty, and I do not want to sound pessimistic, but the dangers of HM, being uncontrollable cells growing (basically cancer cells), and the risk of it matastisizing (spreading) is quite dire and so I highly doubt that the FDA will let HM or HC slide with ease. Who knows though, maybe hair cells will be good and stay hair cells and follow chemical orders in the body, instead of growing uncondtrollably and spreading to say your brain and causing brain cancer.... hopefully they will but we have to put it in a humans head or heads to know so we gotta start from somewhere... fingers crossed....
Don't get confused between Hair Cloning (HC) and Hair Multiplication (HM). HC is using stem cells (found in bone marrow, hair cells, embryonic) and triggering them to re-create hair follicles only. The reason why we can clone a sheep from stem cells is because eventually, that is what the stem cell is programmed to do. It's very complicated to understand without a science background, but basically each and every cell, whether it is a stem cell or not has the book of directions to make a whole new you. The beauty of stem cells is that they are NOT programmed or assigned to use a certain chapter of directions to create a certain body part. Regular cells only use/read a certain chapter of the directions it has; it has the whole book, but only uses and only can use certain chapters. Stem cells can be triggered to use all or some of the chapters. That is why it is easier to clone a whole organism, rather than just a specific body part because it is harder to know the certain signals it takes to trigger a cell to become say, a hair cell. Or in otherwords, it is harder to tell the cell to just read or restrict certain chapters of a book than allow it to read the whole book. On the drawback, the newly cloned individual will have less telomeres, and thus age quicker. As we saw with dolly the sheep, the poor sheep had arthritis and other geriatric ailments even though she was very young. Those are some obstacles that stem cell research has yet to fix.
HM, on the other had, is gathering and culturing cells, and then re-inserting these cells back into the scalp. Cells always divide, until they die usually by degredation, when the products it makes becomes corupt and foreign to the body. (Cancer cells are just that, cells that are corupt, they multiply immensly, do not follow any chemical signals, and they produce byproducts that can be toxic to the body. Normally these cells would be tagged as non-self and destroyed, but they are not dude to genetic factors related to the immune system, etc) The beauty of stem cells is that when they divide, one of them stays a stem cell, and the other matures to become say a hair follicle eventually. Therefore, you will always have a resivorie of stem cells. Only certain organs have stem cells, bone marrow and hair cells being most popular. That is why we age, our non stem cells divide less rapidly as we get older, then we see wrinkles etc etc. The decreased ability of cell regeneration (not speaking of stem cells) is AGING... That's it folks, lack of regeration causes impaired organ functioning.
DHT and other hair loss factors strict the bloodflow, nutrients to the cell and thus all cells die stem cell or not. Once a stem cell is dead, it is dead, it will not be able to regereate itself. This is why people who are bald for long periods of time have extreme difficulty with growing hair back from dormant follicles. Because in actuality, their hair folicles are either extremely miniturized, or absent. The blood is the cells way to get food, without blood or with minimal blood, atrophy of the cell results. This is balding my friends. We know DHT is a culprit, but there may be many many factors....
HM will circumvent this phenomenona by insterting cells taht are resistant to DHT and hair loss factors. These hairs stay on our heads for ever due to genetic factors we are not sure of. All we know is that they will be there, and so the cells we take from them, will produce hair that will stay. HM, will use stem cells from these follicles and create new hair cells that will be injected back into the scalp and hopefully be able to manifest into a hair follicle. It is not cloning. In fact, this is what goes on in your body, HM is basically taking it out of the body, and putting the cells back into the body where appropriate. Oh ya, if you inject a hair cell in your head, it will divide into a stem cell and a hair cell. We dont' know why, it just does, it's because hair cells have that special ability to regenerate itself. And the body only keeps a certain amount of stem cells, it's not like a perpetual cycle.. We have less stem cells than hair cells for sure but if a stem cell dies, then it will be replaced etc.
Honeslty my explanation is quite curtailed, it takes a long time to understand biological processes to even fathom how much we DO NOT KNOW about our bodies especially at the cellular level. Honeslty, and I do not want to sound pessimistic, but the dangers of HM, being uncontrollable cells growing (basically cancer cells), and the risk of it matastisizing (spreading) is quite dire and so I highly doubt that the FDA will let HM or HC slide with ease. Who knows though, maybe hair cells will be good and stay hair cells and follow chemical orders in the body, instead of growing uncondtrollably and spreading to say your brain and causing brain cancer.... hopefully they will but we have to put it in a humans head or heads to know so we gotta start from somewhere... fingers crossed....
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these vintage threads hurt. Look at the comments.
"yay possibly a new weapon to fight male pattern baldness!"
In 10 years my profile should say "kiwipilu was last seen: 7y ago"
Ye.. because the cure comes in 2020 !
the only members who will be here in 2027 are the ones who want better tips to have better looking hairs. *facepalm*
"yay possibly a new weapon to fight male pattern baldness!"
In 10 years my profile should say "kiwipilu was last seen: 7y ago"
Ye.. because the cure comes in 2020 !
the only members who will be here in 2027 are the ones who want better tips to have better looking hairs. *facepalm*