International Investigative Dermatology 2008 Program

[LinuxCavalier]

http://www.iid2008.org/images/ProgrambookIID08.pdf

I looked and haven't seen this posted on here. There is just a TON of stuff to go through

Right off the bat two interesting things:

"Human hair follicle contains two forms of ATP sensitive potassium channels, only one of which is sensitive to minoxidil"

"CRH-mediated stress response of in vitro cultured human anagen hair follicles from men expressing androgenic alopecia is modified by caffeine"


There also appears to have been a presentation entitled: "Attempt of human hair follicle regeneration in vivo and in vitro" - Jiro Kishimoto

Cotsarelis' name is both:

WNT Modulates differentiation status of interfollicular epidermal melanocytes arising for melanocyte sttem cells in the hair follicle bulge after wounding or uvb irradiation

Cd200 alpha-6-integrin keratinocytes possess characteristics of early stem cell progeny, are depleted in androgenic alopecia, and localize to the bulge of the secondary hair germ

 

[LinuxCavalier]

I JUST realized abstracts are accessible too

heres how:
http://iid2008.abstractcentral.com/viewer.jsp

get id numbers from:
http://www.iid2008.org/images/iid2008_abstracts.pdf or the original program pdf

seems the viewer server is having problems, they are also available here:
http://www.nature.com/jid/journal/v128/n1s/index.html

 

[harold]

Some of these stuff looks the same or very similar to stuff from EHRS. Some not.
The following sound interesting - at least to me. Good find.
hh

459 Microdermabrasion with a coarse grit diamond-studded
hand piece induces a wound healing response and
dermal extracellular matrix remodeling in human skin in
vivo. DJ Karimipour, S Kang, T Hamilton, TM Johnson, JS
Orringer, C Hammerberg, GJ Fisher and JJ Voorhees. Ann
Arbor, MI.

853 Analysis of gene expression profiles in hair root cells
and their relation to hair properties. H Taguchi, S Ueda,
S Moriwaki and T Kitahara. Tochigi, Japan.

867 Effect of several monoterpenes on hair growth. C Kim,
D Choi, J Lee, S Hwang, H Cho, C Kim, S Lee and S Kang.
Daejeon, South Korea.


881 Microarray analysis of freshly-microdissected intact
human dermal papilla identified upregulation of genes
that could contribute to biological distinctiveness. M
Ohyama, A Shimizu, T Kobayashi and M Amagai. Tokyo,
Japan.

884 Selective PPAR? agonists but not antagonists decrease
sebaceous gland size in the Fuzzy rats. M Rivier, P
Mauvais, J Boiteau, L Clary and A Jomard. Sophia Antipolis,
France.

886 Selective PPAR? agonists antagonize DHT-induced
effect on sebaceous glands in the Fuzzy rat. A Jomard,
G Feraille, L Clary, J Boiteau and M Rivier. Sophia Antipolis,
France.

889 Commercial-scale production of wnts for inducing hair
follicle growth and neogenesis as a treatment for
alopecias. F Zeigler and GK Naughton. San Diego, CA.

905 Efficacy of adenosine on female pattern hair loss and
male androgenetic alopecia. H Oura, M Iino, R Ideta, Y
Nakazawa, J Kishimoto and S Arase. Yokohama, Japan
and Tokushima, Japan.

894 Effect of oxygen on premature senescence of balding
dermal papilla cells in vitro identifies oxidative stress as
a potential mechanism of androgenetic alopecia. AW
Bahta, N Farjo, B Farjo and MP Philpott. London, United
Kingdom and Manchester, United Kingdom.

898 Molecular mechanism of TGF-?1 promoter activation by
androgen in balding dermal papilla cells. S Inui, T
Nakao, T Nakajima and S Itami. Suita-shi, Japan.

902 Hair-inducing ability of cultured human dermal papilla
cells. J Kishimoto, Y Shirakata, S Fuziwara, T Soma and K
Hashimoto. Yokohama, Japan and Ehime, Japan.

903 PPAR binding protein as a key regulator of hair cycle in
mice. T Nakajima, S Inui and S Itami. Suita, Japan.

904 L-ascorbic acid 2-phosphate magnesium salt induces
secretion of IGF-1 from dermal papilla cells to promote
elongation of hair shafts in vitro. SH Shin, MK Kim, JC
Kim and YK Sung. Daegu, South Korea.

911* Functional overlap of ectodysplasin and troy signalling
pathways in skin appendage development. J Pispa, M
Pummila, P Barker, I Thesleff and M Mikkola. Helsinki,
Finland and Montreal, Canada.

910 Differences of gene expression profiles related to
androgenetic alopecia. JW Oh, YK Sung, JC Kim and MK
Kim. Daegu, South Korea.

908 Evaluation of free oxygen radical and antioxidant
capacity in alopecia areata. C Huh, H Cho, D Kim, B Kim,
H Ryu, S Youn and K Park. Seongnam, South Korea and
Seoul, South Korea.

937 Hedgehog signaling and sebaceous gland maintenance.
M Grachtchouk, A Wang, J Gudjonsson, J Liu, J Ferris and
AA Dlugosz. Ann Arbor, MI.

 

[harold]

Actually this would also be interesting - as a cosmetic technique there are not many scientific articles on the exact effects of dermabrasion on skin and how/why it makes skin look better.

169 Photoprotective effects of chemical peeling agents
against ultraviolet-induced photoaging in hairless mice.
MM Abdel-Daim, Y Funasaka, H Matsunaka, M Ooe and C
Nishigori. Kobe, Japan.

I also find this one interesting as it talks about UV radiation being used instead of wounding although the focus is on melanocytes but not hair.

934* Wnt modulates the differentiation status of
interfollicular epidermal melanocytes arising from
melanocyte stem cells in the hair follicle bulge after
wounding or UVB irradiation. M Ito, J Nguyen, P Myung,
L Garza, T Andl, S Millar and G Cotsarelis. Philadelphia,
PA.

 

[LinuxCavalier]

this one is by histogen

Commercial-scale production of wnts for inducing hair follicle growth and neogenesis as a
treatment for alopecias
F Zeigler1 and GK Naughton2 1 Histogen, Inc., San Diego, CA and 2 San Diego State
University, San Diego, CA

Three-dimensional cultures of human neonatal fibroblasts were grown under hypoxic conditions
that simulate the embryonic environment (3-5% oxygen) to enhance human extracellular matrix
(ECM) production and secretion of growth factors associated with the fetal environment. Under these
conditions a number of growth factors key to tissue development and regeneration were significantly
elevated, including several WNT proteins such as WNTs 5a, 7a, and 11. The activity of the WNT
signals was confirmed by the conditioned media’s ability to induce nuclear translocation of ?-catenin,
and thus canonical WNT signaling, in human keratinocytes in vitro. We tested the hypothesis that
concentrated WNT and growth factor containing media could stimulate epidermal stem cells to
regenerate new hair follicles in normal mouse skin. Both active and control media were injected
once into C57Bl/6 mice. 17/18 overall mice in 3 different experiments injected with this product
candidate, which is derived from the conditioned medium of hypoxic ECM in vitro (HGEN-001),
showed the induction of new hair follicles after 2-4 weeks. The number and location of follicles
induced to cycle being apparently proportional to the volume of material injected. None of the vehi-
cle control mice, or those injected with medium conditioned by monolayer fibroblasts, displayed
new hair growth, and 1/12 mice displayed hair growth effects when injected with adult cell condi-
tioned medium. When actively growing anagen skin of 2 week old mice was injected with HGEN-
001, conversion to catagen/telogen was blocked and the anagen phase was extended, as evidenced
by darker skin color at the injection site when compared to the vehicle control and the presence of
higher numbers of morphologically-identified anagen follicles by histology. In summary, completely
human HGEN-001 without bovine serum has been produced in commercially-scalable fermenta-
tion style bioreactors, and we are currently preparing for GMP manufacturing of HGEN-001, prior
to commencing clinical trials with volunteers with androgenic alopecia.