Interesting use of hydrocortisone..

[Rage]

GH is widely expressed in human skin (6) and is likely to be involved in sebaceous gland development, stimulates sebocyte differentiation, and also augments the effect of 5alpha -dihydrotestosterone on sebaceous lipid synthesis (16). We investigated the effect of GH on feedback regulation of CRH-R expression and found that GH switched completely the predominant CRH-R1 in human sebocytes to CRH-R2. Interestingly, CRH-R1 and CRH-R2 expression is hair cycle dependent; CRH-R1 is mainly expressed in hair compartments of murine anagen follicles and is absent in telogen ones, whereas CRH-R2 expression is higher in telogen and decreases during anagen progression (20). Therefore, testosterone, by down-regulating CRH-R1 mRNA levels, and, especially, GH, by down-regulating CRH-R1 and up-regulating CRH-R2 mRNA levels, may represent signals for induction of hair loss.

Corticotropin-releasing hormone: An autocrine hormone that promotes lipogenesis in human sebocytes
Christos C. Zouboulis*,dagger, Holger Seltmann*, Naoki HiroiDagger ,§, WenChieh Chen¶, Maggie Young§, Marina Oeff*, Werner A. ScherbaumDagger , Constantin E. Orfanos*, Samuel M. McCann||, and Stefan R. BornsteinDagger ,§

And may you ask what has this got to do with hydrocorisone? That's because HC inhibits the secretion of CRH. This is quite possibly the mechanism by which HC is said to have the side effect of "excessive hair growth".

This is in addition to it's other known effects:

> Antagonist to Insulin (see http://www.drmirkin.com/men/M119.htm)

> Inhibitor of the immune system and inflammation (http://www.ehrs.org/conferenceabstracts ... -tosti.htm)

> Inhibits production of CRH


http://www.ncbi.nlm.nih.gov/entrez/quer ... t=Abstract

And it's actually used for hair cell cultures for scientific studies!

 

[beaner]

There are posters on HLH who use hydrocortisone their heads. One guy claims it's grown temple hair. I"ve heard long term use of this is not good for you though.

 

[IBM]

There are posters on HLH who use hydrocortisone their heads. One guy claims it's grown temple hair. I"ve heard long term use of this is not good for you though.

I heard that it may cause glaucoma.

 

[Cassin]

There are posters on HLH who use hydrocortisone their heads. One guy claims it's grown temple hair. I"ve heard long term use of this is not good for you though.

I think it was Dr Pickart who cited long term damages to the scalp from over use.

People do some crazy shiat for short term benefits.

 

[Rage]

I heard that it may cause glaucoma.

That's only if you use HC internally, a very mild solution would not have that effect.. unless you want to put it in your eyes.

I think it was Dr Pickart who cited long term damages to the scalp from over use.

Are you referring to http://www.haarweb.nl/forum/showthread.php?t=670 ? I think the risks from a weak corticosteroid (0.5% HC) combined with the low absorption means I think very little, if any, will more beyond the localised area.

I'm trying small amounts of HC (.5%) once a week !