joseph49853
Experienced Member
- Reaction score
- 12
I wanted to post this to the "Scare stories or for real!?" thread, but decided to make a new topic instead. Just in case everyone in the 'Dealing with Side Effects' forum hasn't seen these. I believe we all should be afforded the right to make informed decisions about our own health... naysayers, money-makers, apologists, and those in denial be damned.
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Cytologic Atypia in a 53-Year-Old Man With Finasteride-Induced Gynecomastia
This is a documented case of a physician himself taking finasteride for hairloss and then developing, not only gynecomastia, but cytologic atypia, as determined by a biopsy. Bascially 'cytologic atypia" is a benign breast disease, which is associated with an increased risk of future breast cancer."The patient was a 53-year-old physician treated for alopecia with the drug finasteride (1 mg per day). After 10 weeks of therapy, he developed a 3-cm-diameter mass in the right breast, which was clinically believed to be gynecomastia. A fine-needle aspiration biopsy was performed using a 22-gauge needle and a 10-mL syringe; the aspirated material was placed into 0.9% sodium chloride solution."
The most interesting and revealing passages include, "Gynecomastia is a known complication of a variety of conditions characterized by hormonal imbalance. Several drugs, including chemotherapeutic agents used to treat prostate and other cancers, have been associated with gynecomastia.....Typically, the gynecomastia resolves after the drug is discontinued. Rarely, ductal or lobular carcinomas of the male breast have been documented to arise in these cases. The cytology of these cancers is similar to that seen in females....We believe this case report also represents the first description of the cytologic changes associated with finasteride therapy....The Food and Drug Administration and case reports in the literature have documented an association between finasteride and gynecomastia.... While male breast carcinoma is exceedingly unusual, we found 2 documented instances of adenocarcinoma, including a lobular carcinoma, arising in association with finasteride therapy."
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Case report: finasteride-induced gynecomastia in a 62-year-old man
The most revealing passages, "there were no pathologic conditions affecting other organs or pharmacologic treatments that could be responsible for gynecomastia.....It is possible that gynecomastia was caused by alterations of estrogen/androgen ratio because of a finasteride-induced decrease in circulating dihydrotestosterone levels....the authors confirm finasteride antiandrogenic activity and recommend a close follow-up of long-term treatments with finasteride to find out other possible side effects."
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Male Breast Cancer During Finasteride Therapy
This is a 2004 report in the Journal of the National Cancer Institute. A clinical study based on men taking 5mg of finasteride (Proscar) to treat benign prostate hyperplasia (BPH.)
"Conditions that result in relative estrogen excess or lack of androgen are associated with an increased risk of breast cancer in both women and men. An example of increased rates of male breast cancer associated with increased estrogen-to-testosterone ratios can be seen in men with Klinefelter's syndrome, who are 50 times more likely to develop breast cancer than their normal counterparts. This ratio may be affected by finasteride (Proscar), which has been widely marketed and used to treat benign prostate hyperplasia (BPH).....we strongly recommend that the FDA require that information about the possible association between male breast cancer and Proscar be clearly stated in the manufacturer's patient information leaflet for prescriptions and in its advertisements."
+++++++++++++++++++++++++++++++++++++++++++
Cytologic Atypia in a 53-Year-Old Man With Finasteride-Induced Gynecomastia
This is a documented case of a physician himself taking finasteride for hairloss and then developing, not only gynecomastia, but cytologic atypia, as determined by a biopsy. Bascially 'cytologic atypia" is a benign breast disease, which is associated with an increased risk of future breast cancer."The patient was a 53-year-old physician treated for alopecia with the drug finasteride (1 mg per day). After 10 weeks of therapy, he developed a 3-cm-diameter mass in the right breast, which was clinically believed to be gynecomastia. A fine-needle aspiration biopsy was performed using a 22-gauge needle and a 10-mL syringe; the aspirated material was placed into 0.9% sodium chloride solution."
The most interesting and revealing passages include, "Gynecomastia is a known complication of a variety of conditions characterized by hormonal imbalance. Several drugs, including chemotherapeutic agents used to treat prostate and other cancers, have been associated with gynecomastia.....Typically, the gynecomastia resolves after the drug is discontinued. Rarely, ductal or lobular carcinomas of the male breast have been documented to arise in these cases. The cytology of these cancers is similar to that seen in females....We believe this case report also represents the first description of the cytologic changes associated with finasteride therapy....The Food and Drug Administration and case reports in the literature have documented an association between finasteride and gynecomastia.... While male breast carcinoma is exceedingly unusual, we found 2 documented instances of adenocarcinoma, including a lobular carcinoma, arising in association with finasteride therapy."
+++++++++++++++++++++++++++++++++++++++++++
Case report: finasteride-induced gynecomastia in a 62-year-old man
The most revealing passages, "there were no pathologic conditions affecting other organs or pharmacologic treatments that could be responsible for gynecomastia.....It is possible that gynecomastia was caused by alterations of estrogen/androgen ratio because of a finasteride-induced decrease in circulating dihydrotestosterone levels....the authors confirm finasteride antiandrogenic activity and recommend a close follow-up of long-term treatments with finasteride to find out other possible side effects."
+++++++++++++++++++++++++++++++++++++++++++
Male Breast Cancer During Finasteride Therapy
This is a 2004 report in the Journal of the National Cancer Institute. A clinical study based on men taking 5mg of finasteride (Proscar) to treat benign prostate hyperplasia (BPH.)
"Conditions that result in relative estrogen excess or lack of androgen are associated with an increased risk of breast cancer in both women and men. An example of increased rates of male breast cancer associated with increased estrogen-to-testosterone ratios can be seen in men with Klinefelter's syndrome, who are 50 times more likely to develop breast cancer than their normal counterparts. This ratio may be affected by finasteride (Proscar), which has been widely marketed and used to treat benign prostate hyperplasia (BPH).....we strongly recommend that the FDA require that information about the possible association between male breast cancer and Proscar be clearly stated in the manufacturer's patient information leaflet for prescriptions and in its advertisements."
