Inhibiting DHT has it's limits?

[Mopless]

I seem to remember a study that concluded that lowering scalp DHT only helps hair-loss to a certain degree and basically having a plateau effect.

Does anyone recall this study? Or remember anything about it? I almost wonder if I somehow made this up in my mind somehow, I'm so uncertain.

 

[Jaeger]

I am new here so sorry if i can't be any help but are you trying to tackle DHT only topically for yourself?

 

[Mopless]

No, I take oral finasteride. But I thought this study would applied to anything topical or oral.

 

[hairrific]

Oral finasteride and dutasteride can only go so far because it seems even if you eliminate all blood serum levels of DHT , DHT is still made locally in the follicular level which does not respond completely to oral DHT inhibitors. That is why tropical application is always being researched and If you can eliminate all DHT locally at the scalp, then YES! you will have no hair loss at all.

Not sure if there is a study, anyone?

 

[moonbase]

Bahhaa.. Sorry for off topic post but that avatar is amazing Hairiffic!

 

[baller234]

Oral finasteride and dutasteride can only go so far because it seems even if you eliminate all blood serum levels of DHT , DHT is still made locally in the follicular level which does not respond completely to oral DHT inhibitors. That is why tropical application is always being researched and If you can eliminate all DHT locally at the scalp, then YES! you will have no hair loss at all.

Not sure if there is a study, anyone?

Why would one part of the body not respond to oral 5ar inhibitors when the rest does?

 

[Bryan]

That is why tropical application is always being researched...

Are you saying they're always researching hairloss medications in tropical locations like Tahiti and Hawaii?

 

[DHR]

ba dum tiss

 

[rcom440]

That is why tropical application is always being researched...

Are you saying they're always researching hairloss medications in tropical locations like Tahiti and Hawaii?

hehehe

 

[abcdefg]

There are other forms of androgens other then just testosterone and DHT. Its as always much much more complicated that what science even understands so far. Im not an expert at any of this but we know testosterone and other androgens such as Androstenedione or Androsterone do bind with androgen receptors in some amount so over time in those that are susceptible you would think they all would cause slow hairloss over time even in absence of being converted into more powerful forms of androgens like DHT.
You would think someone with no DHT at all would still lose hair if susceptible just from testosterone or other much weaker forms of androgens over time maybe just at a much slower rate?

 

[spstriken]

Hi abcdefg

I used saw palmotto for 5-6 months and now I am suffering from Saw palmetto side effects. I have been off almost 12 months and sitll have side effects similar to finasteride users.
I am having low testosterones, low libido, low appetite and muscle and weight loss. Did you have thes all?


May I ask
1- how long did you use Saw palmetto
2- how long did it take to you to become normal
3- What did you do to treat these sides.

I would apprieciate

thanx

SPS

 

[abcdefg]

Well I used saw palmetto for around 6 months. It took a while for the sides to basically just wear off. It happens so gradually its really hard to say I did not keep track of it day by day. It took a while though like weeks for it to gradually go back to normal after stopping saw palmetto. I just figured with sexual sides I am better off using finasteride because that has been studied a lot more.

 

[spstriken]

Well I used saw palmetto for around 6 months. It took a while for the sides to basically just wear off. It happens so gradually its really hard to say I did not keep track of it day by day. It took a while though like weeks for it to gradually go back to normal after stopping saw palmetto. I just figured with sexual sides I am better off using finasteride because that has been studied a lot more.[/quo

did you use powdered SP or liquid 320 mg soft gel caps.


thanx

sps

 

[abcdefg]

320 liquid gel caps from GNC. The main problem is you have no real idea what dose, or basically anything about it. I had effects from it but with how little is known about it I just figured it wasnt worth it and I may as well use propecia under an actual doctors guidance.
I have the prescription but its more then a year old and I decided to wait for a while and see how it goes since its not that bad. Im holding out that in a year or two we will have a safer and hopefully not outrageously expensive topical approved by the FDA.

 

[spstriken]

320 liquid gel caps from GNC. The main problem is you have no real idea what dose, or basically anything about it. I had effects from it but with how little is known about it I just figured it wasnt worth it and I may as well use propecia under an actual doctors guidance.
I have the prescription but its more then a year old and I decided to wait for a while and see how it goes since its not that bad. Im holding out that in a year or two we will have a safer and hopefully not outrageously expensive topical approved by the FDA.

If you take my adviec don't use any thing finasteride or dutasteride ANYTHING DHT INHIBITOR will give you sides. Consider yourself lucky that you got well after SP sides. I think I mad zero recovery in 12 months period. I have read stories of guys who first used finasteride , no gain then they went on dutasteride and then ended up on TRT for life.

 

[Hoppi]

This is why I have such a wildly over-the-top regimen! lol

 

[abcdefg]

My general feeling is for men that are destined for a Norwood 7 with heavy genetics that know they are going bald big time the current treatments are worth trying. For someone that is young with not much of a family history of male pattern baldness, and just a little barely noticeable thinning I dont know if the cost/risk is worth it given our current batch of treatments. If you can wait for a few years and its progressing very slowly you might be better off waiting to see what happens. The next treatment might cost an arm and a leg nothing in science is ever guaranteed. You could end up on propecia for the next 30 years that is a very expensive and possibly risky investment. Its a tough choice though especially when its nearly impossible to know if your even going to go bald or not.