If finasteride blocks DHT, how could it not work?

[2020]

since DHT is responsible for hair loss and Finasteride blocks it, the hair loss should stop permanently. Yet it still doesn't work for some people and you will still go bald eventually. Why is that? Why is this not a perfect drug? What would a perfect drug in the future have to do in order to stop baldness?

 

[UKguy84]

finasteride doesn't block 100% of DHT so what remains can still do damage depending on your hairs sensitivity to DHT.
Over time I heared your hair gets more and more sensitive to DHT, which would obviously lower the effectiveness of finasteride even more.

a perfect drug wud have to make your hair DHT proof i guess.

 

[2020]

finasteride doesn't block 100% of DHT so what remains can still do damage depending on your hairs sensitivity to DHT.
Over time I heared your hair gets more and more sensitive to DHT, which would obviously lower the effectiveness of finasteride even more.

a perfect drug wud have to make your hair DHT proof i guess.

why finasteride doesn't block 100% of DHT? was it made like that on purpose by finasteride creators in order to reduce side effects?
If I take more finasteride, will it block more DHT? I'm on 1mg/day now and I've had zero side effects. Would it make sense to up the dose?

 

[chessmaniac12]

finasteride doesn't block 100% of DHT so what remains can still do damage depending on your hairs sensitivity to DHT.
Over time I heared your hair gets more and more sensitive to DHT, which would obviously lower the effectiveness of finasteride even more.

a perfect drug wud have to make your hair DHT proof i guess.

why finasteride doesn't block 100% of DHT? was it made like that on purpose by finasteride creators in order to reduce side effects?
If I take more finasteride, will it block more DHT? I'm on 1mg/day now and I've had zero side effects. Would it make sense to up the dose?

it doesnt make sense. you wont block %100 of DHT even if you take 5 mg finas. The amount that 5mg finas. blocks DHT and the amount that 1mg finas blocks DHT are pretty close.

maybe you can add topical anti-androgens to your regimen.

 

[UKguy84]

It would make sence to try Dutasteride if you've been on finasteride over a year and your hairloss continues, 5mg of finasteride wont help much more then 1mg.

I believe finasteride was designed for your prostate, its good because most people dont get sides, it doesnt turn you into a women, really it doesnt effect most people at all except by growing your hair.

There are stronger drugs about. I think transgender ones maybe.
They might make you grow moobs and wear a thong, but will benefit your hair alot more. I'm sure I read a post on here about ultimate regimen.
It involved you becoming a girl basically.

 

[Bryan]

At a dose of 5 mg per day, finasteride inhibits about 90% of the type 2 enzyme. My guess is that at 1 mg per day, it's probably around 85% to 90% or so.

 

[gh05]

At a dose of 5 mg per day, finasteride inhibits about 90% of the type 2 enzyme. My guess is that at 1 mg per day, it's probably around 85% to 90% or so.

I thought studies had shown 1mg to be way less than 85-90? like maybe 65-70 and then just about 30 at the scalp?

 

[Bryan]

At a dose of 5 mg per day, finasteride inhibits about 90% of the type 2 enzyme. My guess is that at 1 mg per day, it's probably around 85% to 90% or so.

I thought studies had shown 1mg to be way less than 85-90? like maybe 65-70 and then just about 30 at the scalp?

It sounds like you're confusing changes in serum DHT with what I was talking about specifically, which is just the effect on the type 2 enzyme. I still think that's around 85% to 90%.

 

[gh05]

At a dose of 5 mg per day, finasteride inhibits about 90% of the type 2 enzyme. My guess is that at 1 mg per day, it's probably around 85% to 90% or so.

I thought studies had shown 1mg to be way less than 85-90? like maybe 65-70 and then just about 30 at the scalp?

It sounds like you're confusing changes in serum DHT with what I was talking about specifically, which is just the effect on the type 2 enzyme. I still think that's around 85% to 90%.

yeah ok, my mistake.

out of interest - do you know if the important thing to be considering when treating baldness is the reduction of DHT at the scalp or in the blood or a combination of both?

 

[Bryan]

out of interest - do you know if the important thing to be considering when treating baldness is the reduction of DHT at the scalp or in the blood or a combination of both?

I never talk about "scalp DHT" myself, because I don't see that it's particularly important. The scalp has a significant amount of the type 1 enzyme just from sebaceous glands, which I don't think is very important; I don't know why other people talk about it all the time!

More important in my opinion would be hair follicle DHT, but I don't know any simple way to measure that.

 

[abcdefg]

If you remove DHT 100 percent but you had high testosterone levels could the testosterone still cause hair to miniaturize if maybe slower then DHT would? If your hair can become more sensitive to androgens then it seems testosterone could become more potent since it is also an androgen although a weaker form.

 

[Bryan]

If you remove DHT 100 percent but you had high testosterone levels could the testosterone still cause hair to miniaturize if maybe slower then DHT would?

That's the assumption I've always had, even if it's constantly "DHT this...DHT that..." from other people on hairloss sites!