Human Fetal Scalp Dermal Papilla Enriched Genes and the Role of R-Spondin-1 in the Restoration of Hair Neogenesis in Adult Mouse Cells

[InBeforeTheCure]

The sequel to this study...

Abstract

Much remains unknown about the regulatory networks which govern the dermal papilla’s (DP) ability to induce hair follicle neogenesis, a capacity which decreases greatly with age. To further define the core genes which characterize the DP cell and to identify pathways prominent in DP cells with greater hair inductive capacity, comparative transcriptome analyses of human fetal and adult dermal follicular cells were performed. 121 genes were significantly upregulated in fetal DP cells in comparison to both fetal dermal sheath cup (DSC) cells and interfollicular dermal (IFD) populations. Comparison of the set of enriched human fetal DP genes with human adult DP, newborn mouse DP, and embryonic mouse dermal condensation (DC) cells revealed differences in the expression of Wnt/β-catenin, Shh, FGF, BMP, and Notch signaling pathways. We chose R-spondin-1, a Wnt agonist, for functional verification and show that exogenous administration restores hair follicle neogenesis from adult mouse cells in skin reconstitution assays. To explore upstream regulators of fetal DP gene expression, we identified twenty-nine transcription factors which are upregulated in human fetal DP cells compared to adult DP cells. Of these, seven transcription factor binding motifs were significantly enriched in the candidate promoter regions of genes differentially expressed between fetal and adult DP cells, suggesting a potential role in the regulatory network which confers the fetal DP phenotype and a possible relationship to the induction of follicle neogenesis.

link

 

[pegasus2]

This should be interesting.

 

[bugbug]

https://www.ichimaru.co.jp/english/brand/burgeon-up/

 

[-G-]

https://www.ichimaru.co.jp/english/brand/burgeon-up/

Can you buy it?

 

[jake_b]

Watercress Liquid Extract, OrganicWatercress (Nasturtium officinale) Tincture 4 oz https://www.amazon.com/dp/B00KLGDWU8/ref=cm_sw_r_cp_api_glc_fabc_GJZ5FbWN2GMQN

 

[-G-]

Watercress Liquid Extract, OrganicWatercress (Nasturtium officinale) Tincture 4 oz https://www.amazon.com/dp/B00KLGDWU8/ref=cm_sw_r_cp_api_glc_fabc_GJZ5FbWN2GMQN

Thanks.

 

[HairCook]

It is also part of a product:

All about CRESSATINE® in RevivScalp™ and how it can help encourage hair growth

CRESSATINE in RevivScalp Rejuvenating Scalp Serum Masque | boosts KGF | strengthens hair bulb | prolongs anagen hair phase | helps form well-structured hair

revivserums.com

Though I am not sure what the second natural extract does regarding hair. Would probably avoid anything.

They need to stop being lazy and screen for the very molecules that produce the wanted effects, so we can have them purified without
and wild set of random molecules that might actually affect hair growth negatively. Besides natural stuff is usually anyways too weak.

 

[werefckd]

"Much remains unknown about the regulatory networks which govern the dermal papilla’s (DP) ability to induce hair follicle neogenesis, a capacity which decreases greatly with age."

*Hair Follicle Neogenesis* is a confusing term that I see in a lot of studies and that I believe is misused and losely defined. Do they mean that new follicles are created or that the same hair follicle creates new hairs? I think they mean the later but if you just read the term without context it means the first. Hence I think the term is poorly worded.