Human Essential Fatty Acid DeficiencyTreatment by Topical Application of Linoleic Acid
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I think this post is probably the best on this weeks top 10 list..
I was reading just this week about lipids & human scalp.. How balding men seem to have less fat in scalp than non balding..
I’ve read this take on balding for a decade.. but never experimented..
But it just so happen I ordered a Creme with purports to add lipids to where applied.. So in the name of Tom Edison I ordered it..
I was reading just this week about lipids & human scalp.. How balding men seem to have less fat in scalp than non balding..
I’ve read this take on balding for a decade.. but never experimented..
But it just so happen I ordered a Creme with purports to add lipids to where applied.. So in the name of Tom Edison I ordered it..
This is one of those things that is cheap enough to try and it could conceivably work to an extent. The guy didn't have male pattern baldness...but hair loss is hair loss. What percentage of Androgenetic Alopecia is actually Androgenetic Alopecia caused? There are numerous other confounding variables besides just androgens obviously..
Also, interesting that he regrew his eyebrows back which are thought to be androgen resistant. My eyebrows thinned about the same time as when Androgenetic Alopecia kicked in for me at 17 years old..
A 48 oz bottle of cold pressed sunflower oil at Walmart is around 8 bucks without preservatives. Store in refrig to avoid it going rancid.
A person could easily slather their head for an hour before shampooing with this or even use in combo with a dermaroller/stamp.
re: fat-
Facial aging involves loss of fat too and it has always been my belief that whatever helps wrinkles will likely also be effective with male pattern baldness.
pmc.ncbi.nlm.nih.gov
Also, interesting that he regrew his eyebrows back which are thought to be androgen resistant. My eyebrows thinned about the same time as when Androgenetic Alopecia kicked in for me at 17 years old..
A 48 oz bottle of cold pressed sunflower oil at Walmart is around 8 bucks without preservatives. Store in refrig to avoid it going rancid.
A person could easily slather their head for an hour before shampooing with this or even use in combo with a dermaroller/stamp.
re: fat-
Facial aging involves loss of fat too and it has always been my belief that whatever helps wrinkles will likely also be effective with male pattern baldness.
Role of adipose tissue in facial aging - PMC
Age-dependent modification of the facial subcutaneous white adipose tissue (sWAT) connected with reduction of its volume, modification of collagen content and adhesion between dermal and adipose layers can significantly influence mechanical ...
pmc.ncbi.nlm.nih.gov
I wonder if his regrowth was entirely due to a linoleic acid deficiency or that linoleic acid at low doses induced hormesis.Time to pick up some safflower oil which is 71% linoleic acid.
pmc.ncbi.nlm.nih.gov
www.mdpi.com
Recent findings have demonstrated that linoleic acid enhances antioxidant capacity through activating the adenosine monophosphate-activated protein kinase (AMPK) signaling pathway and the AMPK–target of rapamycin (TOR) signaling pathway in hepatocytes [21].
Enemies or Allies? Hormetic and Apparent Non-Dose-Dependent Effects of Natural Bioactive Antioxidants in the Treatment of Inflammation
Enemies or Allies? Hormetic and Apparent Non-Dose-Dependent Effects of Natural Bioactive Antioxidants in the Treatment of Inflammation - PMC
This review aims to analyze the emerging number of studies on biological media that describe the unexpected effects of different natural bioactive antioxidants. Hormetic effects, with a biphasic response depending on the dose, or activities that are ...
pmc.ncbi.nlm.nih.gov
Linoleic Acid Induces Metabolic Reprogramming and Inhibits Oxidative and Inflammatory Effects in Keratinocytes Exposed to UVB Radiation
Linoleic Acid Induces Metabolic Reprogramming and Inhibits Oxidative and Inflammatory Effects in Keratinocytes Exposed to UVB Radiation
Linoleic acid (LA), the primary ω-6 polyunsaturated fatty acid (PUFA) found in the epidermis, plays a crucial role in preserving the integrity of the skin’s water permeability barrier. Additionally, vegetable oils rich in LA have been shown to notably mitigate ultraviolet (UV) radiation-induced...
www.mdpi.com
Recent findings have demonstrated that linoleic acid enhances antioxidant capacity through activating the adenosine monophosphate-activated protein kinase (AMPK) signaling pathway and the AMPK–target of rapamycin (TOR) signaling pathway in hepatocytes [21].
That's what's up...
pmc.ncbi.nlm.nih.gov
Under the screening for the growth rate (%) of ___human follicles dermal papilla cells (HFDPCs)__, we identified linoleic acid (LA) and oleic acid in n-hexane of M. verticillate (MH)2 fraction.
LA treatment activated Wnt/β-catenin signaling and induced HFDPCs growth by increasing the expression of cell cycle proteins such as cyclin D1 and cyclin-dependent kinase 2. LA treatment also increased several growth factors, such as vascular endothelial growth factor, insulin-like growth factor-1, hepatocyte growth factor, and keratinocyte growth factor, in a dose-dependent manner.
Besides, LA significantly inhibited Dickkopf-related protein expression (DKK-1), a primary alopecia signaling by dihydrotestosterone. Our findings suggest that LA treatment may alleviate a testosterone-induced signaling molecule and induces HFDPCs growth by activating Wnt/β-catenin signaling.
Activation of Hair Cell Growth Factors by Linoleic Acid in Malva verticillata Seed
Activation of Hair Cell Growth Factors by Linoleic Acid in Malva verticillata Seed - PMC
Hair loss by excessive stress from work and lifestyle changes has become a growing concern, particularly among young individuals. However, most drugs for alopecia impose a plethora of side effects. We have found the powerful impact of Malva ...
pmc.ncbi.nlm.nih.gov
Under the screening for the growth rate (%) of ___human follicles dermal papilla cells (HFDPCs)__, we identified linoleic acid (LA) and oleic acid in n-hexane of M. verticillate (MH)2 fraction.
LA treatment activated Wnt/β-catenin signaling and induced HFDPCs growth by increasing the expression of cell cycle proteins such as cyclin D1 and cyclin-dependent kinase 2. LA treatment also increased several growth factors, such as vascular endothelial growth factor, insulin-like growth factor-1, hepatocyte growth factor, and keratinocyte growth factor, in a dose-dependent manner.
Besides, LA significantly inhibited Dickkopf-related protein expression (DKK-1), a primary alopecia signaling by dihydrotestosterone. Our findings suggest that LA treatment may alleviate a testosterone-induced signaling molecule and induces HFDPCs growth by activating Wnt/β-catenin signaling.
Do you have a research link about the balding men having less fat in scalp? I am intetested in this as well
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I am with yours, but my advice is that jojoba oil must be in the mix
I'm looking more at jojoba oil but I also have my eye keenly on oleic acid because of this study. Probably if something works for bph it will also work for male pattern baldness. Also notice the fibrosis in bph caused by the mitchondrial malfunction.
pubmed.ncbi.nlm.nih.gov
Oleic acid (OA) was tested as a bypass of complex I inhibition. Aged mice were treated with OA to examine its effects on urinary dysfunction. Voiding was assessed longitudinally, and a critical complex I protein measured.
Results: Mitochondrial function and fibrosis genes were altered in BPH. Essential mitochondrial proteins (ie, voltage-dependent anion channels 1 and 2, PTEN-induced kinase 1, and NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [NDUFS3]) were significantly (p < .05) decreased in BPH. Complex I inhibition in cultured cells resulted in decreased respiration, altered NDUFS3 expression, increased collagen deposition, and gene expression. OA ameliorated these effects. OA-treated aged mice had significantly (p < .05) improved voiding function and higher prostatic NDUFS3 expression.
Conclusions: Complex I dysfunction is a potential contributor to fibrosis and lower urinary tract dysfunction in aged mice. OA partially bypasses complex I inhibition and therefore should be further investigated as a mitochondrial modulator for treatment of LUTS/BPH. Hypotheses generated in this investigation offer a heretofore unexplored cellular target of interest for the management of LUTS/BPH.
__________________________
Fasting exerts mitochondrial control and eliminates the fissioned malfunctioning mitochondria and short term fasting(or probably also mimetics) promote fusion equally resulting in more ATP and less ROS.
www.longecity.org
I believe the topical lard study could have worked some because lard contains 44-47% oleic acid and 6-10% linoleic acid.
Aging-Related Mitochondrial Dysfunction Is Associated With Fibrosis in Benign Prostatic Hyperplasia - PubMed
Complex I dysfunction is a potential contributor to fibrosis and lower urinary tract dysfunction in aged mice. OA partially bypasses complex I inhibition and therefore should be further investigated as a mitochondrial modulator for treatment of LUTS/BPH. Hypotheses generated in this...
pubmed.ncbi.nlm.nih.gov
Oleic acid (OA) was tested as a bypass of complex I inhibition. Aged mice were treated with OA to examine its effects on urinary dysfunction. Voiding was assessed longitudinally, and a critical complex I protein measured.
Results: Mitochondrial function and fibrosis genes were altered in BPH. Essential mitochondrial proteins (ie, voltage-dependent anion channels 1 and 2, PTEN-induced kinase 1, and NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [NDUFS3]) were significantly (p < .05) decreased in BPH. Complex I inhibition in cultured cells resulted in decreased respiration, altered NDUFS3 expression, increased collagen deposition, and gene expression. OA ameliorated these effects. OA-treated aged mice had significantly (p < .05) improved voiding function and higher prostatic NDUFS3 expression.
Conclusions: Complex I dysfunction is a potential contributor to fibrosis and lower urinary tract dysfunction in aged mice. OA partially bypasses complex I inhibition and therefore should be further investigated as a mitochondrial modulator for treatment of LUTS/BPH. Hypotheses generated in this investigation offer a heretofore unexplored cellular target of interest for the management of LUTS/BPH.
__________________________
Fasting exerts mitochondrial control and eliminates the fissioned malfunctioning mitochondria and short term fasting(or probably also mimetics) promote fusion equally resulting in more ATP and less ROS.
Oleic acid works like resveratrol (David Sinclair Interview) - Resveratrol
Oleic acid works like resveratrol (David Sinclair Interview) - posted in Resveratrol: I just stumbeled across this video with David Sinclair. https://www.youtube....SL3g1Hg#t=26m37 Summary about what Sinclair said: Oleic acid is produced when we are hungry by a breakdown of fat and it...
I believe the topical lard study could have worked some because lard contains 44-47% oleic acid and 6-10% linoleic acid.
https://sci-hub.se/10.1001/archderm.1954.01540230051006 found the study. Actually no, this is another study on scalp thickness only, my bad
this is a related study https://sci-hub.se/10.1111/j.1600-0560.1975.tb00209.x
this is a related study https://sci-hub.se/10.1111/j.1600-0560.1975.tb00209.x
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A big part of what makes balding scalps different from hairy scalps is the hair itself. Hairs need blood supply & tissue to be supported and the scalp skin adjusts to the need. If you transplant thick healthy donor hairs into the balding area, then the skin starts reverting to its thicker pre-balding condition.
I've seen also where hair transplants died off after a decade or so.
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I am agree, but the key is the location in scalp not irrigation issues.
Exactly,
Androgenetic Alopecia has often been thought to be an early marker for insulin resistance.
Safflower seed oil improves insulin sensitivity and reduces inflammation and fat mass in post-menopausal women. I would guess the same happens in men too but there is no study on that. Since post-menopausal women more resemble men in their hormones it wouldnt be that much of a stretch to extrapolate the same things happening to men. The women in the study were not deficient in linoleic acid either.
In the study., the women consumed 8g(8000 mg)/day of safflower oil. Which works out to about 9 ml/day using cooking oil as the density proxy for safflower oil.
www.inchcalculator.com
Just figuring men are about 50% heavier to make it easier..then that is roughly 9x1.5 = 13.5 ml/day for men. Rough it out to 15 ml and that would equal a tablespoon per day. 15 ml = 0.50 ounces and 1 TABLESPOON = 0.50 ounces.
Taking a tablespoon per day or maybe slightly less would equal what the women took in the study.
pmc.ncbi.nlm.nih.gov
We conclude that eight grams of SAF daily improved glycemia, inflammation, and blood lipids indicating that small changes in dietary fat quality may augment diabetes treatments to improve risk factors for diabetes-related complications.
Both treatments provided 8 grams of oil daily, which was consumed in 1-gram capsules provided by Cognis Corporation (Cincinnati, Ohio). The CLA treatment contained a total of 6.4 grams of mixed isomer CLA (50% each of c9t11 and t10c12-CLA) out of 8 grams of total oil. The SAF treatment contained a total of 8 grams of safflower oil. Subjects were instructed to take two capsules each at breakfast, lunch, dinner, and a snack. Fatty acid content of the capsules was verified by gas chromatography analysis10.
Safflower seed oil improves insulin sensitivity and reduces inflammation and fat mass in post-menopausal women. I would guess the same happens in men too but there is no study on that. Since post-menopausal women more resemble men in their hormones it wouldnt be that much of a stretch to extrapolate the same things happening to men. The women in the study were not deficient in linoleic acid either.
In the study., the women consumed 8g(8000 mg)/day of safflower oil. Which works out to about 9 ml/day using cooking oil as the density proxy for safflower oil.
mg to mL Converter (Milligrams to Milliliters) - Inch Calculator
Convert milligrams to milliliters (mg to mL) with the cooking and baking weights and measures conversion calculator, and learn the calculation formula.
Just figuring men are about 50% heavier to make it easier..then that is roughly 9x1.5 = 13.5 ml/day for men. Rough it out to 15 ml and that would equal a tablespoon per day. 15 ml = 0.50 ounces and 1 TABLESPOON = 0.50 ounces.
Taking a tablespoon per day or maybe slightly less would equal what the women took in the study.
Time-dependent effects of safflower oil to improve glycemia, inflammation and blood lipids in obese, post-menopausal women with type 2 diabetes: a randomized, double-masked, crossover study - PMC
Metabolic effects of dietary fat quality in people with type 2 diabetes are not well-understood. The study objective was to evaluate effects of conjugated linoleic acid (CLA) and safflower (SAF) oils on glycemia, blood lipids, and inflammation. The ...
pmc.ncbi.nlm.nih.gov
We conclude that eight grams of SAF daily improved glycemia, inflammation, and blood lipids indicating that small changes in dietary fat quality may augment diabetes treatments to improve risk factors for diabetes-related complications.
Both treatments provided 8 grams of oil daily, which was consumed in 1-gram capsules provided by Cognis Corporation (Cincinnati, Ohio). The CLA treatment contained a total of 6.4 grams of mixed isomer CLA (50% each of c9t11 and t10c12-CLA) out of 8 grams of total oil. The SAF treatment contained a total of 8 grams of safflower oil. Subjects were instructed to take two capsules each at breakfast, lunch, dinner, and a snack. Fatty acid content of the capsules was verified by gas chromatography analysis10.
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Try it,
Speaking of that, I noticed that a lot of balding men seem to have some sort of eczema. Is there any connection there?