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It seems that the topical finasteride or topical dutasteride is a powerful method for anti hairloss. Unfortunately, I lived in China and I can not get them...how can I try it at home?
I don't want to try the minoxidil.... it accelerate the hairlossing for me. Could you recommend something else?Take 12 5mg pills. Crush them and add to 60 mls of minoxidil. Shake until the powder dissolves. Maybe filter
No. I am in the same position as you.I don't want to try the minoxidil.... it accelerate the hairlossing for me. Could you recommend something else?
Take 12 5mg pills. Crush them and add to 60 mls of minoxidil. Shake until the powder dissolves. Maybe filter
Objective: The effects on scalp and serum dihydrotestosterone (DHT) of different doses of a novel topical solution of 0.25% finasteride (P-3074), a type 2 5α-reductase, were investigated in men with androgenetic alopecia. Methods: Two randomized, parallel-group studies were conducted. Study I: 18 men received 1 mL (2.275 mg) P-3074, applied to the scalp once a day (o.d.) or twice a day (b.i.d), or 1 mg oral tablet o.d. for 1 week. Study II: 32 men received P-3074 at the dose of 100 (0.2275 mg), 200 (0.455 mg), 300 (0.6285 mg), or 400 (0.91 mg) μL or the vehicle o.d. for 1 week. Scalp and serum DHT and serum testosterone were evaluated at baseline and treatment end. Results: Change from baseline in scalp DHT was -70% for P-3074 o.d. and approx. -50% for P-3074 b.i.d. and the tablet. Serum DHT decreased by 60 - 70%. The doses of 100 and 200 μL P-3074 resulted in a -47/-52% scalp DHT reduction, similar to the 300 and 400 μL doses (i.e., -37/-54%). A -5.6% inhibition was observed for the vehicle. Serum DHT was reduced by only -24/-26% with 100 and 200 μL P-3074 and by -44/-48% with 300 and 400 μL P-3074. No relevant changes occurred for serum testosterone.
Conclusions: The novel finasteride 0.25% solution applied o.d. at the doses of 100 and 200 μL results in an appropriate inhibition of scalp DHT potentially minimizing the untoward sexual side-effects linked to a systemic DHT reduction.
https://www.researchgate.net/public...one_in_healthy_men_with_androgenetic_alopecia
wouldnt this be a 50% solution?
in studies they operate with 0,25% solutions?
but then again in this study they say 2.275mg in 1ml minoxidil is a 0,25% solution?
My lack of chemistry and math skills is apparently disturbing
(12x5mg) = 60mg into 60mls = 1mg/ml = 0.1% finasteride
1000mg /ml = 100% so move the decimal to the left 3 places when dividing % by 1000
I'm a chemist, so I'm used to working with mg and ml and ppm and % conversions in metric
500mg/ml is 50%
how much ml do you apply on your scalp on average though? even if you just receed slightly at the corner 1ml doesnt sound that much..as that would be already the use of 1mg no?
Not sure yet because I haven't used it, but the fact remains that it's a 0.1% solution. Just use an eye dropper then. The idea is to prevent DHT in the scalp so it wouldn't be practical to add it in strategic small areas I guess. Can't help you anymore than that.
im thinking about microdising 0.15mg orally so applying 1mg+ daily at my scalp sounds a bit concerning
how much ml do you apply on your scalp on average though? even if you just receed slightly at the corner 1ml doesnt sound that much..as that would be already the use of 1mg no?
Just use an eye dropper. Even 1 drop is still 0.1% solution. How much you put on is up to you
im thinking about microdising 0.15mg orally so applying 1mg+ daily at my scalp sounds a bit concerning
