I have been using Minoxidil for over 35 years. I missed maybe 3 or 4 days in all those years. I started when I was about 21. As soon as I saw thinning, I jumped on it and this is when Rogaine first came out. The only side effects that I can tell: 1. I do have bags under my eyes and darker spots. I am not sure if it is minoxidil. 2. I think after all these years my scalp cannot take the propylene glycol. It causes bad breakouts. More so in Florida and less so in Colorado. I have to go to foam or a non PG liquid minoxidil. I am checking non-PG liquid versions because the foam does not appear to be working as well. The thing that heals the breakouts best appears to be garlic, onion, apple cider vinegar and tiny amount of olive oil blended. This is also supposedly a hair growth mix but I am not sure it works. 3. I look a bit younger than others my age. Heart problems? None but I try to stick with chicken, turkey and fish which has helped keep my blood pressure normal. I exercise and go to the gym. I do the vitamins, biotin, etc.