Armando, I will look at your stuff later, first I want to reply to the dovepress article. I wished I had found an article as comprehensive as that one earlier, it was really helpful for giving me an understanding of all the different methods (liposomes, lipoplex, iontophoresis, microneedling, niosomes, nanoparticles).
One thing that makes searching for hair loss cures confusing that no matter what, drug targeting to the dermal papilla is always called "folicular targeting," or "follicular delivery," even though it often makes no mention of it this means systemic delivery through the follicle or local therapy. There were a few points in that article that referenced this. This was under nanoparticles.
"Topically applied nanoparticles tend to diffuse and accumulate in the hair follicle; these characteristics assign nanoparticles penetration and depot-forming capacities. They are frequently employed for medical and cosmetic purposes. Nanoparticles of ~300 nm in size penetrate more deeply into the pilosebaceous unit than nonparticle contents. These nanoparticles are also stored for a longer time period in the follicular region than nonparticle materials."
So here it's called "depot-forming" though this doesn't mention where in the follicle the particles accumulate.
However, still regarding local use of nanoparticles, the same section says this.
"Moreover, the nanocarrier system can deliver the active drug moiety not only into the skin more deeply but also into the systemic circulation for therapeutic aims. This strategy is successfully applied in numerous nanoparticulate formulations, such as polymeric, metallic, and lipid nanoparticles."
It's not mentioned what criteria is required to make nanoparticles more or less effective at local/systemic use.
One reason I am interested in dermal papilla targeted drug mechanisms is because I think if this were to be utilized effectively, even current drugs could be like a cure, it's just how they're applied. This hope of mine lies on the idea that if the drug was only delivered to the dermal papilla, side effects could be avoided. I'm assuming that if every drug molecule reaches the desired location, the cell (with the drug inside) will not result in adverse side effects. However, I don't know this. Let's say a drug like CB is targeted 100% to the papilla with no systemic absorption (I know it doesn't really work this way). Do you think the cells with the CB inside will still end up being metabolized by the body the way it would if it were simply
floating free in the blood stream somewhere? New drug delivery systems seem like they could be a real cure, but if for some reason the drug-in-cell combo still gets broken down into some side effect causing compound that would suck.
