bornthisway
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I'll be busy for a few more days but here's something more to add,
study size=270 / ages=14-58 / norwood 3 & 4, it was observed that higher levels of DHT in patients less than 26 years of age is an indicator of favorable response to 1mg finasteride. A 50% decrease in the younger group was noticed over the course of the year, notably at 6 months. After a year, PSA levels decreased more so in those greater than 26 years of age. They also state that no variations in sebum levels were observed from baseline to 6 months to a year. There was no noticeable decrease of DHT in those > 26 years reported.. I don't see why this was omitted since I can't imagine there not being a change. Did all younger patients have high DHT levels at the start? I'll try to see if I can find a copy of this somewhere later... from reading this it would seem there was nothing else significant to report. I'm curious how inflammation and higher DHT affected the younger group, as we have many poor/non-responders to finasteride or minoxidil in that age group and it's usually thought to be the greater sebum production and/or associated inflammation which would make an inhibitory environment for hair growth. Even though each individual in the entire group was in a similar phase of Androgenetic Alopecia (norwood 3 & 4).. this makes me imagine the role of DHT in hair loss may be less significant, especially if those best treated by finasteride have age and high DHT requirements.
Value of hormonal levels in patients with male androgenetic alopecia treated with finasteride: better response in patients under 26 years old.
British Journal of Dermatology. 2008 Mar 20
F.M. Camacho, M.J. GarcÃa-Hernández, J.L. Fernández-Crehuet
Department of Dermatology, Hospital Universitario Virgen Macarena, Avda. Dr Fedriani s/n. 41071 Sevilla, Spain.
F.M. Camacho.
E-mail: camachodp_AT_medynet.com
Background: Finasteride is a 5alpha-reductase inhibitor that has proved to be an effective treatment for men with androgenetic alopecia.
Objectives: To investigate the hormonal influence of finasteride 1 mg daily on hormonal levels and hair growth in men of different ages and with different degrees of alopecia according to the Hamilton-Norwood scale.
Methods: Two hundred and seventy men aged 14-58 years with male androgenetic alopecia III-VI Hamilton-Norwood score (II-III Ebling score) were treated with finasteride 1 mg daily. Steroid hormone (free testosterone, 5alpha-dihydrotestosterone, dehydroepiandrosterone-sulphate, delta4-androstenedione, 17-hydroxyprogesterone), prostate-specific antigen (PSA) and sebum levels, and trichogram changes were determined at baseline, and at 6 and 12 months of treatment.
Results: According to significant hormonal statistical analysis, the patients were divided by age (up to or over 26 years). In the group of patients </= 26 years, higher levels of 5alpha-dihydrotestosterone were found at the beginning of the treatment, but there was a 50% decrease between the onset of treatment and month 12, particularly noticeable at 6 months (P < 0.05) of treatment, running parallel to an improvement of the alopecia and an increase of anagen hairs in the trichogram. At 1 year, PSA levels decreased 20%, particularly in patients > 26 years. No variations in sebum levels were observed.
Conclusions: High levels of 5alpha-dihydrotestosterone in patients </= 26 years at the beginning of treatment are a predictive factor of good response to treatment with finasteride 1 mg daily.
PMID: 18363752
study size=270 / ages=14-58 / norwood 3 & 4, it was observed that higher levels of DHT in patients less than 26 years of age is an indicator of favorable response to 1mg finasteride. A 50% decrease in the younger group was noticed over the course of the year, notably at 6 months. After a year, PSA levels decreased more so in those greater than 26 years of age. They also state that no variations in sebum levels were observed from baseline to 6 months to a year. There was no noticeable decrease of DHT in those > 26 years reported.. I don't see why this was omitted since I can't imagine there not being a change. Did all younger patients have high DHT levels at the start? I'll try to see if I can find a copy of this somewhere later... from reading this it would seem there was nothing else significant to report. I'm curious how inflammation and higher DHT affected the younger group, as we have many poor/non-responders to finasteride or minoxidil in that age group and it's usually thought to be the greater sebum production and/or associated inflammation which would make an inhibitory environment for hair growth. Even though each individual in the entire group was in a similar phase of Androgenetic Alopecia (norwood 3 & 4).. this makes me imagine the role of DHT in hair loss may be less significant, especially if those best treated by finasteride have age and high DHT requirements.
Value of hormonal levels in patients with male androgenetic alopecia treated with finasteride: better response in patients under 26 years old.
British Journal of Dermatology. 2008 Mar 20
F.M. Camacho, M.J. GarcÃa-Hernández, J.L. Fernández-Crehuet
Department of Dermatology, Hospital Universitario Virgen Macarena, Avda. Dr Fedriani s/n. 41071 Sevilla, Spain.
F.M. Camacho.
E-mail: camachodp_AT_medynet.com
Background: Finasteride is a 5alpha-reductase inhibitor that has proved to be an effective treatment for men with androgenetic alopecia.
Objectives: To investigate the hormonal influence of finasteride 1 mg daily on hormonal levels and hair growth in men of different ages and with different degrees of alopecia according to the Hamilton-Norwood scale.
Methods: Two hundred and seventy men aged 14-58 years with male androgenetic alopecia III-VI Hamilton-Norwood score (II-III Ebling score) were treated with finasteride 1 mg daily. Steroid hormone (free testosterone, 5alpha-dihydrotestosterone, dehydroepiandrosterone-sulphate, delta4-androstenedione, 17-hydroxyprogesterone), prostate-specific antigen (PSA) and sebum levels, and trichogram changes were determined at baseline, and at 6 and 12 months of treatment.
Results: According to significant hormonal statistical analysis, the patients were divided by age (up to or over 26 years). In the group of patients </= 26 years, higher levels of 5alpha-dihydrotestosterone were found at the beginning of the treatment, but there was a 50% decrease between the onset of treatment and month 12, particularly noticeable at 6 months (P < 0.05) of treatment, running parallel to an improvement of the alopecia and an increase of anagen hairs in the trichogram. At 1 year, PSA levels decreased 20%, particularly in patients > 26 years. No variations in sebum levels were observed.
Conclusions: High levels of 5alpha-dihydrotestosterone in patients </= 26 years at the beginning of treatment are a predictive factor of good response to treatment with finasteride 1 mg daily.
PMID: 18363752