hold your horses NEW TREATMENT phase 2 trials!

[dutch]

http://www.hairlosshelp.com/forums/mess ... adid=65220

FANTASTIC NEWS !!!!!!!!!!!!!!!!!!!!!!!!!!!!


04 Jan 07
Neosil Announces Positive Phase 2 Data for NEOSH101, an Investigational Treatment for Androgenetic Alopecia

EMERYVILLE, CA -- (MARKET WIRE) -- January 04, 2007 -- Neosil, Inc., a privately held dermatology-focused pharmaceutical company, today announced positive Phase 2a clinical data demonstrating that its lead product, NEOSH101, increased hair growth significantly in men diagnosed with androgenetic alopecia, also known as pattern hair loss (PHL). Androgenetic alopecia or PHL, caused by a combination of genetic and hormonal factors, is noticeable in about 20 percent of the population by age 20 and increases steadily with age. By age 50 approximately half of the U.S. population will have some degree of PHL.*

"Based on the results of this study, we are quite encouraged by the increase in hair growth observed after such a short once-daily treatment regimen with NEOSH101," said Vera H. Price, MD, FRCP(C), Professor of Clinical Dermatology, Department of Dermatology, University of California, San Francisco.

In a randomized, double-blind Phase 2a clinical study, conducted in Germany, 50 men with androgenetic alopecia (Norwood/Hamilton grades III-IV) received once-daily topical treatments of NEOSH101 or placebo over two 14-day treatment periods, which were separated by a one-month drug-free interval. Hair growth was measured using an objective photographic, computer-based analysis for up to 24 weeks after initiation of therapy. Results show that NEOSH101 was safe and well tolerated. A statistically significant increase in total hair count (4.8%, p=0.04), and cumulative hair thickness (3.7%, p=0.02) were observed, with peak effects occurring eight weeks following the second treatment cycle.

"The results of this study are encouraging, particularly the finding of increased numbers of terminal hairs, those hairs that are thicker than 40 microns and desirable for scalp coverage," said Andria Langenberg, M.D., Vice President of Clinical Development at Neosil. "We plan to initiate a Phase 2b study to evaluate daily treatment with NEOSH101 for a longer treatment period in men with PHL."

About Neosil

Neosil, Inc. is a privately held dermatology-focused pharmaceutical company that was funded in November 2004 with a $32 million investment by MPM Capital and Burrill & Company, following initial incubation funding by Shalon Ventures, LP. In addition to its topical hair growth product, NEOSH101, Neosil is developing a broad-spectrum topical anti-microbial agent for acne and anti-infective use.

* Nyholt, D.R., et al.: Genetic basis for male pattern baldness, J. Investig. Dermatol. 121:1651-1564, 2003.

Media Contact:
Karen Halsey
415-946-1077
Email Contact


SOURCE: Neosil

lots more studies in link. also check out

Effect of Hair Cycle Stage

<0175> Skin explants from mice during telogen at 3 weeks of age were cultured for 72 hours, in the presence of proteasome inhibitors, and then the explants were histologically examined. In the untreated control explants, the follicles were few and small. In the explants treated with PSI (50 nM), epoxomicin (25 nM), and the hybrid PSI-epoxide (50 nM), there was an obvious increase in hair follicle diameter, and follicle elongation. Minoxidil also caused these changes, but at concentration s 10,000-fold greater. Since these small follicles resemble the miniaturized follicles seen in male pattern baldness, this suggests these compounds may have the same effects in that situation.

 

[Dblbass128]

Correct me if I am wrong, but isnt this just a topical that will increase hair c*** by 4%? Doesn't Nizoral do more used twice a week?

 

[jcinzano]

4% after a mere 28 days

 

[Far Too Young]

My only concern is that any substance this potent might just have carcinogenic tendencies.

 

[rick055]

Someone help me understand the mechanism...

Okay, minoxidil is some kind of hair growth stimulant, but it doesn't (?) stop further hair loss, right?

Finasteride blocks DHT conversion and therefore, to a degree, stops further hair loss.

What is Neosil doing? Will it stop further androgenetic loss or is it "just" a super minoxidil stimulant? Do we know?

I'm waiting for the topical that stops hair loss and grows hair!!!

 

[Boru]

No way. Treatments can only work with the natural hair cycle, which can never be so short. This is some kind of stock floatation scam, for desperate and easily fooled investors.

 

[sphlanx2006]

Actually if the "dead" hair follicles in telogen were kicked into anagen after 2-3 days, that would give them 25 days to grow about 1cm in length. This would definately increase hair count. Hope it works out, but i am not holding my breath for it.

 

[Boru]

Actually if the "dead" hair follicles in telogen were kicked into anagen after 2-3 days, that would give them 25 days to grow about 1cm in length. This would definately increase hair count. Hope it works out, but i am not holding my breath for it.

Just not blooming possible.

 

[rick055]

Actually if the "dead" hair follicles in telogen were kicked into anagen after 2-3 days, that would give them 25 days to grow about 1cm in length. This would definately increase hair count. Hope it works out, but i am not holding my breath for it.

Just not blooming possible.

BUT, doesn't this seem to suggest that the results were observed 8 weeks after the second treatment?:

In a randomized, double-blind Phase 2a clinical study, conducted in Germany, 50 men with androgenetic alopecia (Norwood/Hamilton grades III-IV) received once-daily topical treatments of NEOSH101 or placebo over two 14-day treatment periods, which were separated by a one-month drug-free interval. Hair growth was measured using an objective photographic, computer-based analysis for up to 24 weeks after initiation of therapy. Results show that NEOSH101 was safe and well tolerated. A statistically significant increase in total hair count (4.8%, p=0.04), and cumulative hair thickness (3.7%, p=0.02) were observed, with peak effects occurring eight weeks following the second treatment cycle.

2 X 14 day treatments = 1 month + 1 month drug free interval = 2 months + 8 weeks after = 4 months. Look at what plain old 5% minoxidil claims to do in similar time on its website. I think this is very plausible.

 

[AussieExperiment]

Not very impressive

rick055 you are right. That is actually 4 months.

4% would hardly be noticeable. I wouldn't bother.

Sounds like a company trying to make a quick buck.

For people who respond to minoxidil the results are way better after 4 months. In fact I would not be suprised if some of the herbal remedies like green tea and Saw Palmetto could achieve 4% regrowth after 4months in some people (and I stress only some people, not all).

Thanks for posting though, I think we should still follow the progress of this product.

 

[Dontwannabeabetabob]

Lol

 

[ZZmop]

Lol

These threads get me every time

 

[Dontwannabeabetabob]

These threads get me every time

Very depressing. Twilight zone.

 

[shookwun]

FANTASTIC NEWS, boys

 

[InBeforeTheCure]

Eleven years later: Hold your horseshoes.

 

[kiwipilu]

 

[whatevr]

God f*****g damn it with the necroing of hype posts from 10 years ago.

 

[sadila]

Oh boy 2020 looks very promising with all these new research and treatments in the pipeline

 

[sadila]

Bumping old threads should be bannable unless you have good reason...

Burst a laugh is enough good reason for me

 

[Dontwannabeabetabob]

Bumping old threads should be bannable unless you have good reason...

Settle down.