High IGF-1 & M.P. Baldness

[DammitLetMeIn]

Basically there have been quite a few studies linking elevated IGF-1 with Male Pattern Baldness.

Moreover, there have also been those which have suggested that IGF-1 stimulates 5-alpha-reductase activity.

I shall list the studies/research and let you make of them what you will.

IGF-1 regulating 5-Alpha-Reductase activity:

http://endo.endojournals.org/cgi/conten ... 447?ck=nck

http://www.ihop-net.org/UniPub/iHOP/pm/ ... id=8344190

IGF-1 and male pattern baldness:

http://www.ncbi.nlm.nih.gov/entrez/quer ... t=Abstract

http://www.ncbi.nlm.nih.gov/entrez/quer ... t=Abstract

'Human hair follicles are targets of sex steroids. In particular, androgens induce regression of terminal (large) hair during the development of male-pattern baldness and transform vellus (small) hair to terminal hair in genital skin during puberty.[55] These effects may be associated with high levels of circulating IGF-1 [56] which directly stimulates the activity of the androgen receptor.[57] It is also possible that IGF-1 stimulates the activity of 5-reductase in the skin which increases the local production of dihydrotestosterone converted from testosterone.'[58]

57. Culig Z, Hobisch A, Cronauer MV, radmayr C, Trapman J, Hittmair A, Bartsch G, Klocker H: Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor. Cancer Res 1994;54:5474-8.

58. Horton R, Pasupuletti V, Antonipillai I: Androgen induction of steroid 5 alpha-reductase may be mediated via insulin-like growth factor-I. Endocrinol 1993;133:447-51.


'In summary, regulation of human hair growth by androgen is probably mediated by IGF-1 in the dermal papilla. In male scalp, high levels of IGF-1 may increase the androgen receptor activity and dihydrotestosterone levels and these result in an increased propensity for baldness.'

http://dermatology.cdlib.org/DOJvol5num ... ws/su.html

'Aberrant activation of the Androgen Receptors has been demonstrated in vitro with IGF-1, keratinocyte growth factor, and epidermal growth factor. These agents can directly activate the Androgen Receptors in the absence of androgens and may contribute to the progression of prostate cancer and AA (43 , 44) .

http://cebp.aacrjournals.org/cgi/conten ... /6/549#B13

Signorello L. B., Wuu J., Hsieh C. C., Tzonou A., Trichopoulos D., Mantzor C. S. Hormones and hair patterning in men: a role for insulin-like growth factor 1?. J. Am. Acad. Dermatol., 40: 200-203, 1999.

Prostate Cancer associated with vertex balding:

http://cebp.aacrjournals.org/cgi/conten ... f_ipsecsha

Association between male pattern baldness and Prostate cancer (4000 + particpants)

http://cebp.aacrjournals.org/cgi/conten ... f_ipsecsha

Androgenetic alopecia and Prostate cancer link association/link:

http://cebp.aacrjournals.org/cgi/conten ... /6/549#B13

***IGF-1 can lead to aberrant activation of the Androgen Receptor***

Blok G. J., de Boer H., Gooren L. J., van der Veen E. A. Growth hormone substitution in adult growth hormone-deficient men augments androgen effects on the skin. Clin. Endocrinol., 47: 29-36, 1997

*** 'Aberrant activation of the Androgen Receptor has been demonstrated in vitro with IGF-1, keratinocyte growth factor, and epidermal growth factor. These agents can directly activate the Androgen Receptor in the absence of androgens and may contribute to the progression of prostate cancer and Androgenetic Alopecia'***

Yeh S., Miyamoto H., Shima H., Chang C. From estrogen to androgen receptor: a new pathway for sex hormones in prostate. Proc. Natl. Acad. Sci. USA, 95: 5527-5532, 1998.


In women:

CONCLUSIONS
Overdosage of IGF-I can lead to androgenization, a previously undescribed undesirable effect of IGF-I. Long-term IGF-I treatment necessitates progressive adjustment of the IGF-I dose to avoid overtreatment.

http://www.blackwell-synergy.com/links/ ... 98.00356.x



Here are some excerpts from some other medical Articles cited by a PhD:

'Our findings suggest that high levels of IGF-1 may be associated with
increased risk of vertex baldness. Substantial clinical evidence
appears to support this finding.'

'It has also been recently reported that GH treatment of GH-deficient
men increases hair scores in androgen-dependent areas. These effects
can be explained either by IGF-1 directly stimulating the androgen
receptor, or by IGF-1 increasing local 5alpha-reductase activity and
thus stimulating the local conversion of testosterone to
dihydrotestosterone.'

'In conclusion, we have found evidence that high levels of testosterone
and IGF-1 increase the likelihood of vertex baldness, whereas neither
of these hormones appears significantly or suggestively associated
with chest hair growth. SHBG is inversely associated with vertex
baldness as well as with chest hair growth, although the association
is significant only with respect to the latter.'

And another:

“We observed that middle-aged and elderly men who reported modest to
substantial vertex balding at age 45 have lower circulating levels of
IGFBP-3 and higher levels of IGF-1 when controlling for IGFBP-3 level.
Growth factors are beginning to emerge as contributors to hair growth
and loss."

Again:

In androgen-responsive tissue, IGF-1 may act locally to positively
mediate the induction of 5-reductase by dihydrotestosterone.12 This
action of IGF-1 may be consequential for the development of balding
because conversion of testosterone to dihydrotestosterone in the scalp
by 5-reductase type 2 is essential for androgenetic alopecia.


Our findings
are compatible with both the direct association of IGF-1 and the
modulating effect of IGFBP-3 on male pattern balding.â€￾

 

[DammitLetMeIn]

Shout out 2 everyone. And bring whatever info. you have regarding IGF-1 and male pattern baldness.

Ps. im aware of a study that says IGF-1 rises on Finisteride.

 

[docj077]

Here is an example of a genetic disorder that involves diabetes, low IGF-1, hypogonadism, AND ALOPECIA. Low IGF-1 is associated with alopecia in these families.


1: Am J Med Genet A. 2007 Jan 15;143(2):149-60. Links
Autosomal-recessive syndrome with alopecia, hypogonadism, progressive extra-pyramidal disorder, white matter disease, sensory neural deafness, diabetes mellitus, and low IGF1.Al-Semari A, Bohlega S.
Department of Neurosciences, King Faisal Specialist Hospital & Research Centre, Riyadh, Kingdom of Saudi Arabia.

We explored the manifestations of an autosomal-recessive multisystemic disorder in several Saudi families. Recognized causes of progressive extra-pyramidal disorder and white matter disease were excluded and the neurological, imaging, endocrine, and skin manifestations of this syndrome described. The onset of these symptoms in these patients began in early adolescence and progressed more rapidly in males. All affected patients had total or partial alopecia, clinical and chemical evidence of hypogonadism (low levels of estradiol and testosterone); females had clear evidence of hypogonadism (streak or absent ovaries), and some patients had diabetes mellitus and/or sensorineural deafness. The constant biochemical abnormality was the low IGF-1. The neurological manifestations included moderate to severe intellectual decline and abnormality of muscle tone and posture with choreo-athetoid and dystonic movements resulting in gait difficulty, dysarthria, difficulty swallowing, and scoliosis. The MRI of brain demonstrated white matter involving cerebellum, brain stem, and cerebral structures, as well as abnormal decreased signal intensity in the basal ganglia with involvement of the substantia nigra. We conclude that the association of hypogonadism, alopecia, and persistent low IGF-1 is a significant autosomal recessive syndrome; it is prevalent in Saudi Arabia. We also demonstrate that the progressive extra-pyramidal disorder, white matter disease, and abnormal signals of the basal ganglia are common features of this syndrome. Sensorineural deafness and diabetes mellitus were recognized features. (c) 2006 Wiley-Liss, Inc

 

[DammitLetMeIn]

Wondered how long before you'd show up in this thread.

These people have diabetes + a genetic disorder - not conventional male pattern baldness.

I could post 50 studies which SHOW a link between IGF-1 and male pattern baldness and you STILL wouldn't go for it.

Your mind is closed, even when presented with facts.

 

[docj077]

Wondered how long before you'd show up in this thread.

These people have diabetes + a genetic disorder - not conventional male pattern baldness.

I could post 50 studies which SHOW a link between IGF-1 and male pattern baldness and you STILL wouldn't go for it.

Your mind is closed, even when presented with facts.

You don't understand the molecular mechanisms, so you can't understand the basic science within the research articles. You still think that plasma levels of IGF-1 correlate with scalp levels of IGF-1. You couldn't be more wrong.

Also, that study does not say whether or not any of the men demonstrated male pattern baldness. That just proves my point regarding your inability to comprehend research articles.

 

[DammitLetMeIn]

You don't understand the molecular mechanisms, so you can't understand the basic science within the research articles. You still think that plasma levels of IGF-1 correlate with scalp levels of IGF-1. You couldn't be more wrong. .

YOU HAVE NO PROOF OF THIS. I HAVE PROOF WHICH SUGGESTS THE CONTRARY.

Also, that study does not say whether or not any of the men demonstrated male pattern baldness. That just proves my point regarding your inability to comprehend research articles.

Theres something like 5 studies which I have presented which suggest male pattern baldness.

I suggest you don't bother entering these threads if you're not going to provide evidence to back up your claims.

 

[DammitLetMeIn]

You don't understand the molecular mechanisms, so you can't understand the basic science within the research articles. .

Don't be silly.

You still think that plasma levels of IGF-1 correlate with scalp levels of IGF-1. You couldn't be more wrong..

Actually, IGF-1 is distributed to tissue via plasma.

Plus, I can see that high IGF-1 correlates with vertex balding over a number of studies. Moreover, it is also likely to be higher in the scalp and other areas of the body given this is the case.

Also, that study does not say whether or not any of the men demonstrated male pattern baldness. That just proves my point regarding your inability to comprehend research articles.

YES IT DOES. What do think vertex balding is? telogen effluvium?