When 5% Spironolactone Lotion is used with Regrowth 5% topical minoxidil or Xandrox 5% (5% minoxidil / 5% azelaic acid), apply the minoxidil solution first. Allow several minutes for it to partially dry. Then apply the 5% Spironolactone Lotion on top of the minoxidil solution. The lotion will act as an occlusive dressing and enhance the absorption of both medications.