Help homebrewing spironolactone solution from bulk powders

[triton2]

In order to do this I'm not using aldactone tabs, I'm using spironolactone in raw powders, but it's giving me lots of problems.
First of all, in order to brew this solution I'm using:

25 ml PPG
25 ml Ethanol
2.5 gr spironolactone

Okay, I mix it, shake it vigorously but, after a while, spironolactone goes straight to the bottom of the bottle. I could be waiting and shaking for days and days and the same problem...
However if I heat it the liquid becomes transparent (it loses the milky colour) and I no longer have the problem I talked about above, BUT after a while it begins making crystals which is also a problem 'cause a lot of spironolactone goes to waste in those crystals. What am I doing wrong? help! :!: :!:

 

[blaze]

it appears to me that the sprio is falling out of solution. Making a 5% spironolactone is hard to do with PPG and Ethanol.

Maybe you would be better of making a 3% version.

How are you heating up the spironolactone solution triton?

Also where are you geting raw spironolactone from triton? Are you sure it is legit?

 

[Bryan]

Triton, what concentration are you shooting for?? You're obviously overdoing it!

Bryan

 

[triton2]

Triton, what concentration are you shooting for?? You're obviously overdoing it!

Bryan

I am not. I am trying to brew 5% spironolactone solution. In order to do that I need, at least, 2.5gr for every 50ml.
If I heat it there's no problem but, after a while, it begins to form insoluble crystals. The method I use for heating it is that of boiling water in a saucepan and afterwards getting it out of the fire, that's when I put the spironolactone into the hot water 'bath'.

 

[Bryan]

YOU'RE OVERDOING IT. Your vehicle can't dissolve that much. Lower the amount of spironolactone until it dissolves completely at room temperature.

Bryan

 

[triton2]

YOU'RE OVERDOING IT. Your vehicle can't dissolve that much. Lower the amount of spironolactone until it dissolves completely at room temperature.

Bryan

Bryan, do you really think it's a matter of overdoing it? Those companies that sell spironolactone lotions sell the 5% version and their lotions seem to be stable, so I think there must be something I'm doing wrong, don't you think?

 

[Bryan]

Bryan, do you really think it's a matter of overdoing it? Those companies that sell spironolactone lotions sell the 5% version and their lotions seem to be stable, so I think there must be something I'm doing wrong, don't you think?

Huh?? Those commercial 5% spironolactone products (like Dr. Lee's) are just CREAMS or LOTIONS. They aren't true SOLUTIONS! They are just spironolactone suspended in various cream vehicles. That doesn't necessarily mean that you're gonna be able to get spironolactone to dissolve into a liquid vehicle at that same concentration.

Bryan

 

[Bryan]

BTW, where'd you get that pure, powdered spironolactone??

Bryan

 

[triton2]

Bryan,

what's the difference between a LOTION and a SOLUTION?
I think the lotion cemproducts sells is just PPG+etanol+spironolactone and people say it's perfect.
I got the spironolactone from a chemist friend of mine.

 

[Bryan]

Bryan,

what's the difference between a LOTION and a SOLUTION?

This is from a chemistry textbook:

"There are two types of solutions, true solutions and colloidal solutions or dispersions. In true solutions, the dissolved particles are small molecules or ions. In colloidal dispersions the dispersed particles are aggregates of small molecules or giant molecules."

In other words, in a true solution, the dissolved substance (the solute) is completely broken down into individual molecules or ions, and dispersed evenly throught the solvent. But in a suspension or a dispersion, the material is only reduced to a fine condition, but still in "clumps" or aggregates of molecules. It's still just a rough, "mechanical" mixture of one substance within another, if you get my drift.

I think the lotion cemproducts sells is just PPG+etanol+spironolactone and people say it's perfect.

What concentration do they claim?

I got the spironolactone from a chemist friend of mine.

He just GAVE it to you??

Bryan

 

[triton2]

Then I guess the lesson to be learned is that you cannot make a lotion at home because you would need special equipment in order to manufacture it, wouldn'd you?
By the way, do you think that it would be easier and more convenient for me to brew a cream instead of a solution? How would you homebrew a spironolactone 5% cream?

I think the lotion cemproducts sells is just PPG+etanol+spironolactone and people say it's perfect.

What concentration do they claim?

5%.

I got the spironolactone from a chemist friend of mine.

He just GAVE it to you??

Bryan

I bought it.

 

[Bryan]

Then I guess the lesson to be learned is that you cannot make a lotion at home because you would need special equipment in order to manufacture it, wouldn'd you?

Why would you say that?

By the way, do you think that it would be easier and more convenient for me to brew a cream instead of a solution?

Depends on the specific creams and solutions that you're talking about.

How would you homebrew a spironolactone 5% cream?

Haven't you seen my little "recipe" for how I make my simple little homebrew 3% spironolactone cream? I've posted that several times. It would work even better for YOU, because you have access to pure spironolactone powder.

What concentration do they claim?

5%.

Well, something seems to be wrong somewhere, if you're unable to get anywhere nearly as much spironolactone to dissolve, using the same solvents. Maybe they're using extra solubility enhancers to increase the amount of spironolactone that they can get to dissolve; but if they refer to it as a "lotion", that makes me suspicious right off the bat. They must be using more than just alcohol and PPG as the solvent/vehicle. Do you have a link to that product?

I bought it.

How much did you pay for it?

Bryan

 

[triton2]

Then I guess the lesson to be learned is that you cannot make a lotion at home because you would need special equipment in order to manufacture it, wouldn'd you?

Why would you say that?

I'm not sure... my chemistry knowledge is very very small. So how would you make such a LOTION if you were having my problem?

How would you homebrew a spironolactone 5% cream?

Haven't you seen my little "recipe" for how I make my simple little homebrew 3% spironolactone cream? I've posted that several times. It would work even better for YOU, because you have access to pure spironolactone powder.

You used dermovan, didn't you?

What concentration do they claim?

5%.

Well, something seems to be wrong somewhere, if you're unable to get anywhere nearly as much spironolactone to dissolve, using the same solvents. Maybe they're using extra solubility enhancers to increase the amount of spironolactone that they can get to dissolve; but if they refer to it as a "lotion", that makes me suspicious right off the bat. They must be using more than just alcohol and PPG as the solvent/vehicle. Do you have a link to that product?

Yes. You can zoom the picture.

http://store1.yimg.com/I/yhst-201891129 ... 857_280742

I bought it.

How much did you pay for it?

Bryan

I think it was around 2$ per gram.

 

[luke77]

Is there any place to buy dermovan or a similar vehicle other than ordering it online?

 

[triton2]

bump

 

[Private Ryan]

from the bottle it appear they are using more PPG than alcohol.

maybe you can try using Rogaine formula mix to try?

 

[powersam]

is it legal to just sell bulk spironolactone like that? i wouldnt have thought so