Has anyone tried create CosmeRNA? Affects Androgen Recptors

[Rumspringa!]

New Hair Growth Cosmeceutical Using siRNA With Published Study: CosmeRNA Review - Follicle Thought

Bioneer Targets H2 2022 Euro Launch Of CosmeRNA: Update (3/9/22) Bioneer/siRNAgen has apparently been evaluating its CosmeRNA product for cosmetic regulatory approval in Germany over the past several months. Various news outlets in the Korean press reported on March 8, 2022 that CosmeRNA has...

folliclethought.com

This is meant to come out later this year in Europe. Reduces the androgen receptors on follicles so would be a good addition to everyone's stack.

Just wondering if anyone has or is working with a lab to make this now, I would be interested.

 

[pegasus2]

IIRC the results are comparable to finasteride, but it's less effective than dutasteride. I doubt anyone would find it worth the expense or hassle.

 

[Kagaho]

MOA is interesting and complementary to that of alpha reductase inhibitors

I don't think it's as effective as monotherapy, but time will tell.

 

[Rumspringa!]

IIRC the results are comparable to finasteride, but it's less effective than dutasteride. I doubt anyone would find it worth the expense or hassle.

It works through a different mechanism, so doing both would work synergistically no?

 

[pegasus2]

It works through a different mechanism, so doing both would work synergistically no?

It works through the same mechanism basically, inhibiting AR. They just do it in different ways. Stacking won't do a lot of good imo. People who want to stack AR antagonists and 5-ARIs are already using RU or pyrilutamide, bica, etc. This is just a way that may have less side effects than traditional AR antagonists, but not more efficacy.

 

[Roeysdomi]

It works through the same mechanism basically, inhibiting AR. They just do it in different ways. Stacking won't do a lot of good imo. People who want to stack AR antagonists and 5-ARIs are already using RU or pyrilutamide, bica, etc. This is just a way that may have less side effects than traditional AR antagonists, but not more efficacy.

Its once a week so not a hassle anyway

 

[pegasus2]

Its once a week so not a hassle anyway

Is it going to show up on your doorstep without doing anything to get it? You can't just order it off Amazon

 

[Roeysdomi]

Is it going to show up on your doorstep without doing anything to get it? You can't just order it off Amazon

Idk we will figure it out

 

[pegasus2]

Idk we will figure it out

It isn't worth the hassle

 

[whatevr]

It isn't worth the hassle

I am definitely interested and I'm probably not the only one around these parts. If it works as well as Finasteride (possible) without side effects (this is really the part I'm skeptical about), then it will definitely find its buyers.

What I don't get is how exactly this can be legally classified as a cosmetic. How is this any different than an androgen receptor degrader, somehow altering genetic expression with siRNA is considered harmless yet a protein degrader has to go through years of trials?

 

[FilthyFrancis]

What I don't get is how exactly this can be legally classified as a cosmetic. How is this any different than an androgen receptor degrader, somehow altering genetic expression with siRNA is considered harmless yet a protein degrader has to go through years of trials?

Yeah I doubt the cosmetic route will be validated by the health agencies

 

[pegasus2]

I am definitely interested and I'm probably not the only one around these parts. If it works as well as Finasteride (possible) without side effects (this is really the part I'm skeptical about), then it will definitely find its buyers.

What I don't get is how exactly this can be legally classified as a cosmetic. How is this any different than an androgen receptor degrader, somehow altering genetic expression with siRNA is considered harmless yet a protein degrader has to go through years of trials?

Why? Aren't you already bald like me? What's the point in something that is only going to prevent you from going more bald. Most people are fine with RU or finasteride. Considering the difficulty in getting this produced in small quantities I don't think many will be too interested in the effort and expense. Now if they had a siRNA for ZNRF3/RNF43 I'd be all over it

 

[whatevr]

Why? Aren't you already bald like me? What's the point in something that is only going to prevent you from going more bald. Most people are fine with RU or finasteride. Considering the difficulty in getting this produced in small quantities I don't think many will be too interested in the effort and expense. Now if they had a siRNA for ZNRF3/RNF43 I'd be all over it

No, I'm "only" a NW3, but diffusing into a NW5 pattern.

 

[pegasus2]

No, I'm "only" a NW3, but diffusing into a NW5 pattern.

About the same. The way I see it I might as well be bald. I have to buzz/shave it regardless. Until we find something that can actually regrow I'm screwed.

 

[EMILIO CHESSA]

About the same. The way I see it I might as well be bald. I have to buzz/shave it regardless. Until we find something that can actually regrow I'm screwed.

But weren't you the one who used everything? did you even get a regrowth?

 

[fashy]

No, I'm "only" a NW3, but diffusing into a NW5 pattern.

About the same for me too.

About the same. The way I see it I might as well be bald. I have to buzz/shave it regardless. Until we find something that can actually regrow I'm screwed.

Not true though. Even a buzzed NW3/NW4 is better than slick bald. Having some semblance of hairline > no hairline at all. I buzz and I am a diffuse NW3 and it's not optimal, but if I can keep it this way for the rest of my life it's still far better than having to shave a non-existent hairline every day.

If this is as efficacious as it allegedly is and has no sides, it's a good alternative to finasteride for people who do not wish to take finasteride like me. It's either this or pyrilutamide for me, otherwise it's pretty much over.

 

[pegasus2]

About the same for me too.



Not true though. Even a buzzed NW3/NW4 is better than slick bald. Having some semblance of hairline > no hairline at all. I buzz and I am a diffuse NW3 and it's not optimal, but if I can keep it this way for the rest of my life it's still far better than having to shave a non-existent hairline every day.

If this is as efficacious as it allegedly is and has no sides, it's a good alternative to finasteride for people who do not wish to take finasteride like me. It's either this or pyrilutamide for me, otherwise it's pretty much over.

OK, buy it then. It's going to cost thousands of dollars. I don't see the point when you can use so many other drugs that are just as effective. I don't bother using anything anymore because really the difference between diffuse NW5 and NW7 is minimal. I doubt I'll ever go full NW7. No one in my family has. This thing is a very niche product for people who get sides on everything else. I'm betting those same people will get sides on this too

 

[pegasus2]

But weren't you the one who used everything? did you even get a regrowth?

Yes, I got lots of regrowth but also got too many side effects

 

[Chads don't bald]

Yes, I got lots of regrowth but also got too many side effects

Which stuff gave you regrowth and what side effects?

 

[pegasus2]

Which stuff gave you regrowth and what side effects?

I was on everything know to man. Pfs.