half-life

[stnl]

can u tell me whats the half-life for finasteride and dutasteride ?

now here is a suggestion -

take a 1 mg finasteride pill and split it into 5 parts and take each part at regular spaced intervals thruoght the day

 

[Pondle]

Finasteride - 6 hours; Dutasteride - 5 weeks. What benefit do you expect to get by splitting your pill and taking bits throughout the day? :?

 

[stnl]

half life is 6 hours so after 6 hours half the effect will be gone, so its better to take it at regular inter vals

perhaps 4 times a day

 

[Guest]

half life is 6 hours so after 6 hours half the effect will be gone, so its better to take it at regular inter vals

please go back to school, johnny. you're disappointing us.

half life of finasteride is irrelevant in this case. it still takes days for the 5ar2 levels to rise again after doses of finasteride.

 

[IBM]

Finasteride - 6 hours; Dutasteride - 5 weeks. What benefit do you expect to get by splitting your pill and taking bits throughout the day? :?

That's interesting. So besides Dutasteride inibiths two types of 5 alpha reductase is more efective because its more time on body?

Sad dutasteride is very expensive. 13$ against 10$ of 5mg Finasteride.

 

[Guest]

Finasteride - 6 hours; Dutasteride - 5 weeks. What benefit do you expect to get by splitting your pill and taking bits throughout the day? :?

That's interesting. So besides Dutasteride inibiths two types of 5 alpha reductase is more efective because its more time on body?

Sad dutasteride is very expensive. 13$ against 10$ of 5mg Finasteride.

No dutasteride is not more effective because it has a longer half life. It is more effective because it inhibits more 5ar2 than finasteride and maybe also a tiny bit more effective because it inhibits 50% of 5ar1 at the 0.5 mg daily dose. All the long half-life does is allow for people to dose it how they want to, like once every 5 days or whatever, and not worry about it.

 

[IBM]

Finasteride - 6 hours; Dutasteride - 5 weeks. What benefit do you expect to get by splitting your pill and taking bits throughout the day? :?

That's interesting. So besides Dutasteride inibiths two types of 5 alpha reductase is more efective because its more time on body?

Sad dutasteride is very expensive. 13$ against 10$ of 5mg Finasteride.

No dutasteride is not more effective because it has a longer half life. It is more effective because it inhibits more 5ar2 than finasteride and maybe also a tiny bit more effective because it inhibits 50% of 5ar1 at the 0.5 mg daily dose. All the long half-life does is allow for people to dose it how they want to, like once every 5 days or whatever, and not worry about it.

Thanks for the reply. I wonder how much stronger is dutasteride every three days against finasteride 1mg everyday... Still dutasteride is an expensive thing.

 

[Bryan]

No dutasteride is not more effective because it has a longer half life. It is more effective because it inhibits more 5ar2 than finasteride

JayMan, one of the reasons that dutasteride is more effective and inhibits more 5ar2 than finasteride is BECAUSE it builds-up in the bloodstream to a much greater extent than finasteride (the longer half-life, in other words).

The two basic, fundamental reasons for why Avodart suppresses DHT better than Propecia:

1) Dutasteride is more potent than finasteride, even on an equal-weight basis: a milligram of dutasteride is more potent at inhibiting 5ar2 than a milligram of finasteride.

2) A given daily dose of dutasteride will eventually build-up to a much higher level in the bloodstream than the same daily dose of finasteride, thanks to the longer half-life.

The powerful 1-2 punch above is what explains dutasteride's superiority over finasteride.

 

[hair today gone tomorrow]

Finasteride - 6 hours; Dutasteride - 5 weeks. What benefit do you expect to get by splitting your pill and taking bits throughout the day? :?

That's interesting. So besides Dutasteride inibiths two types of 5 alpha reductase is more efective because its more time on body?

Sad dutasteride is very expensive. 13$ against 10$ of 5mg Finasteride.

No dutasteride is not more effective because it has a longer half life. It is more effective because it inhibits more 5ar2 than finasteride and maybe also a tiny bit more effective because it inhibits 50% of 5ar1 at the 0.5 mg daily dose. All the long half-life does is allow for people to dose it how they want to, like once every 5 days or whatever, and not worry about it.

Thanks for the reply. I wonder how much stronger is dutasteride every three days against finasteride 1mg everyday... Still dutasteride is an expensive thing.

taking .5 mg of dutasteride 2x a week would be more effective than taking 1mg of finasteride 7x a week.

 

[Guest]

2) A given daily dose of dutasteride will eventually build-up to a much higher level in the bloodstream than the same daily dose of finasteride, thanks to the longer half-life.

Oh I totally agree that 0.5 mg of dutasteride is a lot stronger than 0.5 mg of finasteride, and 0.1 mg of dutasteride is a lot stronger than 0.1 mg of finasteride. the half-life does help and allows for convenient dosing schemes, but if someone is taking either one every day, the half-life of dutasteride doesn't really help that much imo

 

[Bryan]

I think the half-life of dutasteride is responsible for most of its power.

 

[RaginDemon]

half life is 6 hours so after 6 hours half the effect will be gone, so its better to take it at regular inter vals

please go back to school, johnny. you're disappointing us.

:lol:

 

[hair today gone tomorrow]

I think the half-life of dutasteride is responsible for most of its power.

i agree..

I like to think of it as two tanks...

lets say that finasteride and dutasteride = water

the finasteride tank has a large hole at the bottom
the dutasteride tank has a small hole at the bottom

b/c of this the exit rate is a lot smaller for dutasteride so it builds up in your system...where as with finasteride...the exit rate is roughly equal to the entry rate so its not really building up in your system, however you reach steady state a lot quicker with the finasteride (although its much lower)

With dutasteride..since its exiting the tank slower than its entering the tank...the water level is rising everyday consistently...until it reaches its steady state

fins half-life doesn't let the water level rise much since its exiting your system so quickly.

 

[Bryan]

Nice analogy, HTGT!

 

[hair today gone tomorrow]

Nice analogy, HTGT!

thanks!