FairTaxNow said:
Jayman,
Thanks for posting those stats. You mentioned dutasteride reduced 90% more but isn't that rather ( (98.5 - 90) / 98.5 ) = 13.7% more DHT than propecia rather than the 90% more you mentioned? And respectively 8.6% more than Proscar?
You mentioned that it blocks 50% of Type I DHT, how much does propecia block of Type 1 DHT? What does Type I DHT contribute towards follicle degeneration as well?
You're doing a better job of the dutasteride sell than WoW I can say at least, got me a bit more interested too! I have quite a bit of finasteride that's should be arriving monday (if the mailman will knock this time: registered mail) so I pretty much can't make the switch at this point anyways. What are the rate of side effects with dutasteride and this can also be taken every other day and be almost as effective as every day correct? I believe dutasteride has a very long half-life or is it the same reason finasteride can be taken every other day? I know finasteride has a short half life but it just takes the 5AR enzyme quite a few days to start producing again. I thought I remember reading that dutasteride actually had a long half-life though.
I DO know that the seedooo guy who is getting married in 6 months should make the jump over to dutasteride since he's been on 1mg finasteride for a number of years and apparently has just maintained or slowed his hairloss.
Sorry I meant to say that it takes care of 90% of the remaining DHT that the finasteride doesn't basically. 98.5% compared to 90% or 85% may not seem like a huge difference, since they all seem like big numbers, but it really is a difference.
If you think of each percentage point as a DHT soldier carrying a bazooka aimed at your hair follicles, propecia takes care of 85 of the 100 total soldiers, so only 15 are left. Now 15 is obviously better than 100 attacking your hair, but it still leaves your hair vulnerable in the future. Now proscar takes care of 5 more of their soldiers that propecia couldn't, leaving only 10 remaining. But then avodart comes along and takes care of 9 of the 10 remaining soldiers, leaving only 1 of the 100 to damage your hair. Now, I don't know about you, but I'd rather have 1 gun pointed at me than 10 or 15 or 100.
But there are always risks of course, specifically risks to your "gun" in your pants. Avodart did have a higher incidence of side effects than Propecia in studies, I am not sure of the exact numbers. I did read an article on some website that listed the percentage of people who got sexual sides as 13%, but I'm not sure that is accurate. I think it is closer to 6 or 7%. The sides are the same as with propecia but they have higher incidences as I mentioned. I don't really care about the sides for myself on Avodart because I haven't gotten any of them, but I'm sure people who have them do.
Yeah, taking Avodart every other day blocks I think 95% of type II DHT, which is better than Proscar every day, but not as good as taking Avodart every day. Actually, taking 2.5 mg of Avodart every day(5 capsules!) blocks 100% of type II DHT basically, but this is not recommended, and is also quite expensive. We aren't sure how type I DHT contributes, or at least I'm not. It's found in the sebaceuous glands and maybe in tiny amounts in the follicles.
dutasteride does have a much longer half-life than finasteride. The half-life of finasteride is only a few hours while the half-life of dutasteride is measured in weeks. What this means is that if you do get sides from dutasteride, that they will be with you longer, but will eventually disappear. finasteride can be taken every other day because the half-life is not what's important for finasteride dosing. It does take the 5 ar type II enzyme a few days to start producing back at normal capacity after a finasteride dose, you are correct. It takes much longer for it to start producing at normal capacity after a dutasteride dose or two.
Basically, taking one dutasteride capsule every 5 days is equivalent to taking 5 mg of Proscar a day, If I remember correctly.
Once you have reached steady-state(maximum DHT inhibition for that particular dose) on dutasteride, the half-life of it is about 5 weeks.
Following commencing of a daily dose of dutasteride, you are at 65% of steady-state concentration after 1 month and approximately 90% after 3 months. And because of the long-half life, dutasteride can be detected in the blood 4-5 months after discontinuation of it assuming you have already reached a steady state.