yet another in vitro experiment producing hair follicles from stem cells; this is different than the recent article posted by the great noisette. 2018 just may be the year boys!
In scientific first, researchers grow hairy skin in a dish from mouse pluripotent stem cells. This research, recently published in the journal Cell Reports, marks the first demonstration that hair follicles can be grown in cultures of stem cells.
Summary: The mammalian hair follicle arises during embryonic development from coordinated interactions between the epidermis and dermis. It is currently unclear how to recapitulate hair follicle induction in pluripotent stem cell cultures for use in basic research studies or in vitro drug testing. To date, generation of hair follicles in vitro has only been possible using primary cells isolated from embryonic skin, cultured alone or in a co-culture with stem cell-derived cells, combined with in vivo transplantation. Here, we describe the derivation of skin organoids, constituting epidermal and dermal layers, from a homogeneous population of mouse pluripotent stem cells in a 3D culture. We show that skin organoids spontaneously produce de novo hair follicles in a process that mimics normal embryonic hair folliculogenesis. This in vitro model of skin development will be useful for studying mechanisms of hair follicle induction, evaluating hair growth or inhibitory drugs, and modeling skin diseases.
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31803-X
EDIT: my bad guys, looks like this is a rehashing of the research by koehler et al. for what its worth, this is more exposure and a better summary than the previous post
In scientific first, researchers grow hairy skin in a dish from mouse pluripotent stem cells. This research, recently published in the journal Cell Reports, marks the first demonstration that hair follicles can be grown in cultures of stem cells.
Summary: The mammalian hair follicle arises during embryonic development from coordinated interactions between the epidermis and dermis. It is currently unclear how to recapitulate hair follicle induction in pluripotent stem cell cultures for use in basic research studies or in vitro drug testing. To date, generation of hair follicles in vitro has only been possible using primary cells isolated from embryonic skin, cultured alone or in a co-culture with stem cell-derived cells, combined with in vivo transplantation. Here, we describe the derivation of skin organoids, constituting epidermal and dermal layers, from a homogeneous population of mouse pluripotent stem cells in a 3D culture. We show that skin organoids spontaneously produce de novo hair follicles in a process that mimics normal embryonic hair folliculogenesis. This in vitro model of skin development will be useful for studying mechanisms of hair follicle induction, evaluating hair growth or inhibitory drugs, and modeling skin diseases.
http://www.cell.com/cell-reports/fulltext/S2211-1247(17)31803-X
EDIT: my bad guys, looks like this is a rehashing of the research by koehler et al. for what its worth, this is more exposure and a better summary than the previous post
It's pretty interesting