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Hair Cell (full Hair Regeneration)

Discussion in 'New Research, Studies, and Technologies' started by Xaser94, Jul 10, 2016.

  1. Xaser94

    Xaser94 Established Member

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    HairCell is a startup in the Leonhardt Ventures’s Cal-X Stars 5 Year Business Accelerator and Leonhardt’s Launchpads NorCal @ University of Northern California Science & Technology Innovation Center focused on hair regeneration.

    The HairCell technology platform is based on the Leonhardt et. al patent and patent pending portfolio of technologies for a regeneration micro stimulator that controls expressions of specific proteins on demand for specific regenerative purposes in sequence.




    http://leonhardtventures.com/haircell/#toggle-id-3

    Heres there pending patent. Unfortunately. They are just applying for phase 1. But their procedure seems very interesting.

    INVENTION TITLE


    A method and apparatus for producing hair growth stimulation using bioelectric energy, topical compositions, stem cell/growth factor micro infusions and combinations thereof. By using bioelectric signaling resulting from specific protein expressions and their cellular responses to exposure to specific micro voltages.

    BACKGROUND OF THE INVENTION

    Problem Solved: Many people lose hair as they age. Thin hair causes loss of self-esteem.

    Other methods and devices at best increase hair coverage by 10%.

    Our device controls release of SDF-1 a stem cell homing factor as well as IGF-1, HGF, EGF, Follistatin, Tropoelastin, eNOS and VEGF as well as micro infusion delivery of a 15 component hair regeneration cocktail which includes nutrient hydrogel, thus providing all the supporting element to grow a full head of hair.

    DETAILED DESCRIPTION OF THE INVENTION

    As stated above, many people lose hair as they age. Thin hair causes loss of self-esteem. The invention claimed here solves this problem.

    Our devices utilizes specific bioelectric signals to control release of 10 key hair regeneration proteins and for severe cases is combined with a stem cell/growth factor micro infusion pump to regenerate a full head of hair.

    The claimed invention differs from what currently exists. No other product delivers a full complete combination of growth factors and stem cells necessary for complete and full hair regeneration.

    This invention is an improvement on what currently exists. No other product delivers a full complete combination of growth factors and stem cells necessary for complete and full hair regeneration.

    Prior art fails to address all the mechanisms necessary for complete hair regeneration. Most current treatments have nowhere near the volume of active agent necessary to regenerate a full head of thick hair.

    Our device controls release of SDF-1 a stem cell homing factor as well as IGF-1, HGF, EGF, Follistatin, Tropoelastin, eNOS and VEGF as well as micro infusion delivery of a 15 component hair regeneration cocktail which includes nutrient hydrogel, thus providing all the supporting element to grow a full head of hair.

    Also, it can produce Hair regeneration. Hair removal. Skin regeneration.


    The Version of The Invention Discussed Here Includes:

    1. Brain Electroacupuncture Cap
    2. Micro regeneration stimulator and connecting leads
    3. Micro infusion pump
    4. Bioelectric signal program SDF-1 = Stem Cell Homing Factor
    5. Bioelectric signal program IGF-1
    6. Bioelectric signal program HGF
    7. Bioelectric signal program EGF
    8. Bioelectric signal program Follistatin
    9. Bioelectric signal program Tropoelastin
    10. Bioelectric signal program eNOS
    11. Bioelectric signal program VEGF
    12. Bioelectric signal program Activin A + B
    13. Hair regeneration cocktail 15 component composition
    14. Bioelectric signal for cell proliferation
    15. Bioelectric signal to control differentiation
    Relationship Between The Components:

    Brain electroacupuncture cap (1) is placed on head of patient. (2) micro regeneration stimulator is connected to brain cap (1). Micro infusion pump (3) is connected to brain electroacupuncture cap. Micro stimulator runs through a program releases 10 specific proteins for specific purposes all of which work together for complete hair regeneration. In severe cases a micro pump is filled with the HC-15 fifteen component hair regeneration cocktail comprising three types of stem cells, growth factors, nutrient hydrogel, scalp matrix and Micro RNAS as well as known topical solutions for hair regeneration. 12. The method of claim 1 where said bioelectric signal produces eNOS – Alternating high-frequency (HF) and medium-frequency signals (MF) – Symmetric, biphasic, trapezoid pulses, with 400-µs pulse duration and 1.5/1-s ramp-up/ramp-down duration, respectively. HF consisted of 75 Hz pulses with 6 s on–21 s off for 15 minutes. MF consisted of 45 Hz pulses with 5 s on–12 s off for 15 minutes. Followed by stimulation duration set as 20 min for both 1 Hz and 20 Hz stimulations. For 1 Hz stimulation, stimulation was applied for 9 sec, followed by a 1 sec silent period, a total of 1080 stimulations for 20 min. For 20 Hz stimulation, stimulation was applied for 2 sec, followed by silent period for 28 sec, a total of 1600 stimulations for 20 min.

    1. The method of claim 1 where said bioelectric signal produces Activin A – 6mv at 150 HZ Monophasic square wave pulse 0.1 ms in duration current of 15 mA for 15 minutes.
    How The Invention Works:

    The micro hair regeneration stimulator may be used as a standalone. Results are accelerated and enhanced with the addition of the micro infusion pump that is re-filled daily, weekly or monthly. 14. Method of claims 1 to 13 in sequence order of VEGF, eNOS, SDF-1, Proliferation, VEGF, eNOS, HGF, IGF-1, Follistatin, Differentiation, Tropolastin, Follistatin, IGF-1, HGF, SDF-1 and repeated.

    1. Method of claim 1 where bioelectric signal causes controlled expression of FGF.
    2. Method of claim 1 where bioelectric signal causes controlled expression of EGF
    How To Make The Invention:

    The brain cap is adapted from EEG monitoring caps and electro acupuncture needles. The micro stimulator is obtained from an OEM supplier of heart pacemakers. The software is programmed into the stimulator with a standard programmer. The micro pump is obtained from an OEM supplier that makes pumps for drug infusion.

    The micro regeneration stimulator is essential. The brain cap is optional. You can use tape electrodes or standard electro acupuncture needles instead OR the signals can be transmitted by a wireless light like device. The micro infusion pump is optional for severe cases or for accelerating results.

    1. The method of claim 1 where said bioelectric signal produces – stem cell differentiation signals – (Leonhardt Signals) – 200 picoamps for 10 seconds for 1 hr + the pulse has an amplitude of 5 volts and a width of 0.5 milliseconds for 1 hr
    1. The method of claim 1 where said bioelectric signal produces Follistatin – (muscle growth) production signal (Genovese + Leonhardt) – 10V @ 50 HZ and 100 HZ for 12 hrs each
    1. The method of claim 1 where said bioelectric signal produces HGF – Hepatocyte growth factor (arrhythmia reduction) signal (Genovese + Leonhardt) – 3.5V stimulation in 10 second bursts, 1 burst every 30 seconds @ frequency 50 HZ
    1. The method of claim 1 where said bioelectric signal produces IGF-1 (Genovese + Leonhardt) – 3mv with electric frequency of 22 Hz, and electric current of 1 mA for 15 minutes and 3ma for 15 minutes
    1. The method of claim 1 where said bioelectric signal produces Tropoelastin (Genovese + Leonhardt) – 0.06?V with 50Z alternating electrical field and electric current of 1ma for 15 minutes and 3ma for 15 minutes
    1. The method of claim 1 where said bioelectric signal produces RANKL nuclear factor-kappa B (NF-?B) ligand (Genovese + Leonhardt + Marchetto) – 3MV at 2/100 Hz alternating frequency with current of 3ma followed by 15 Hz, 1 Gauss EM field, consisting of 5-millisecond bursts with 5-microsecond pulses followed by 200-µs pulse duration @ 30 Hz and with current amplitude of 140 mA.
    1. The method of claim 1 where said bioelectric signal produces eNOS – Alternating high-frequency (HF) and medium-frequency signals (MF) – Symmetric, biphasic, trapezoid pulses, with 400-µs pulse duration and 1.5/1-s ramp-up/ramp-down duration, respectively. HF consisted of 75 Hz pulses with 6 s on–21 s off for 15 minutes. MF consisted of 45 Hz pulses with 5 s on–12 s off for 15 minutes. Followed by stimulation duration set as 20 min for both 1 Hz and 20 Hz stimulations. For 1 Hz stimulation, stimulation was applied
    How To Use The Invention:

    The brain cap is connected to the stimulator and pump and treatment is 40 minutes 3 times a week for 8 to 36 weeks as needed. Claims (16)

    1. A method for stimulating hair growth, comprising: exposing a hair growth structure to a source of narrow band of bioelectric signals, without having applied a drug, cosmeceutical, and/or chromophore to the hair growth structure;
    bioelectrical signal controlled protein release to promote hair growth by maintaining the exposure of the hair growth structure to the source of narrowband of bioelectric signals for protein expression for a clinically effective duration and at a clinically effective depth to stimulate hair growth without causing skin ablation.

    1. The method of claim 1 wherein said source of narrowband bioelectric signals are delivered by any one of these methods; wireless transmission, electro-acupuncture needles, conductive patches doped with hair growth promoting drugs and proteins, a conduction signal helmet or cap, a metal hair scalp tickler or any combination thereof.
    1. The method of claim 1 where said bioelectric signal produces vascular endothelial growth for factor release VEGF – to promote hair growth and blood vessel sprouting growth 0.1V applied at a frequency of 50 Hz. 4. The method of claim 1 where said bioelectric signal produces SDF-1 – Stem cell recruiting signal (the Leonhardt Signal) – 30 pulses per second with a voltage of 3.5 mV, and successively alternating currents of 700 to 1500 picoamps for one minute, and again with 700 to 1500 picoamps for one minute + stimulated with current of 0.25 mA, pulse duration of 40 pulses/s, pulse width of 100 µs, and frequency of 100 Hz. 5. The method of claim 1 where said bioelectric signal produces – stem cell proliferation signal (Leonhardt-Chachques) – 15 mV and a current of 500 picoamps at 70 pulses per minute for 3 hrs + 20 pulses per minute, a pulse amplitude of from 2.5-6 volts, and a pulse width of from 0.2-0.7 milliseconds for 3 hrs
    Additionally: The micro stimulator + micro pump + regeneration composition + bioelectric signaling programming may be used to regenerate any tissue or organ.

    Also, it can create: Hair regeneration. Hair removal. Skin regeneration.



    ABSTRACT

    A method and apparatus for producing hair growth stimulation using bioelectric energy, topical compositions, stem cell/growth factor micro infusions and combinations thereof. By using bioelectric signaling resulting from specific protein expressions and their cellular responses to exposure to specific micro voltages. Our device controls release of SDF-1 a stem cell homing factor as well as IGF-1, HGF, EGF, Follistatin, Tropoelastin, eNOS and VEGF as well as micro infusion delivery of a 15 component hair regeneration cocktail which includes nutrient hydrogel, thus providing all the supporting element to grow a full head of hair.



    Heres there phase 1 trial design (includes high norwoods)

    http://leonhardtventures.com/wp-content/uploads/2016/05/pilotstudy.pdf


    Alot of the proteins they seem to be stimulating I think are the same as Histogen's. Hopefully this is good news for us.
     
    #1 Xaser94, Jul 10, 2016
    Last edited: Jul 10, 2016
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  2. Giiizmo

    Giiizmo Established Member

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    There's no way I can take them seriously with such a laughable video. Also, the process sounds like just another Pilox.

    Still, good find I guess. See you in 5 years for the cure!
     
  3. Roberto_72

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    Unfortunately, image.jpeg They are writing themselves that it has not proved to do anything yet.
     
  4. Joxy

    Joxy Established Member

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    Just another fantasy world video...
     
  5. hellouser

    hellouser Senior Member My Regimen

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    That's should have been the first thing mentioned in this thread lol.
     
  6. Xaser94

    Xaser94 Established Member

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    I did lol, it was right after the video I said they are just starting Phase 1. So nothing has been technically proven yet. But this reminds me of the replicel video tbh. Not saying this is the cure or nothing. But interesting to follow none the less.

    The founder has a somewhat impressive resume.

    Howard Leonhardt is an inventor and serial entrepreneur. He has 21 U.S. patents with over 100 patent claims for products for treating cardiovascular disease and has over 40 new patent claims pending. His TALENT (Taheri-Leonhardt) stent graft developed in the early 1990′s holds a leading world market share for repairing aortic aneurysms without surgery. His inventions have treated over 500,000 patients in 60 countries. In early 1999 Leonhardt founded Bioheart, Inc. www.bioheartinc.com a leader in applying adult muscle stem cells to treat heart failure.. Leonhardt holds a Diploma in International Trade from Anoka Technical College. He attended the University of Minnesota,Anoka Ramsey College and UCLA Extension. He holds an honorary Doctorate in Biomedical Engineering from the University of Northern California and is an honorary alumnus of the University of Florida and Florida International University. He is co-leader of Startup California and Founder and Chairman of The California Stock Exchange TM (Cal-X) preparing to be the first social good impact stock exchange currently operating the Cal-X 30 Social Good Impact fund powered by Motif Investing- www.calstockexchange.com – He founded Cal-X Crowdfund Connect www.calxcrowdfund.com a crowdfunding campaign management co. and Cal-X Stars Business Accelerator, Inc.www.calxstars.com a business incubator and accelerator focused on cardiovascular life sciences and social good impact innovations. There are 30 regenerative medtech and regenerative economy startups in the current portfolio class. His Leonhardt Ventures angels network has raised and put to work over $145 million in 32 companies to date, most of them founded by Leonhardt. BioLeonhardt www.bioleonhardt.com is developing the first implantable programmable and re-fillable stem cell pump. He leads CerebraCell for brain regeneration. EyeCell for eye regeneration and AortaCell for aorta regeneration and number of other organ regeneration spin offs from his patented core technologies. . Leonhardt serves as state spokesperson in California for the JOBS ACT and Crowdfunding for Startup California and has given over 40 speeches on the subject. He has operated Leonhardt’s Launchpads NorCal at the University of Northern California Science & Technology Innovation Center in Rohnert Park, CA since 2008 and recently opened Leonhardt’s Launchpads Utah in Salt Lake City just off the campus of the University of Utah. He has served on the Board of Directors of the University of Northern California, a private biomedical engineering school, since 1999.
     
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  7. supermusic

    supermusic Established Member

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    No one pic.
    Not be proven.
    This seems a simple electro estimulator.

    Next...
     
  8. Roberto_72

    Moderator

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    And yet the logo for this new enterprise is a little bit amateurish isn't it?
    image.jpg
    Not the mention the video.
    But hey, it was a nice catch. Whatever works.
     

    Attached Files:

  9. atthekeysbored

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    marketing hype, also being a "serial entrepreneur" entering the highly specialized field of hair loss therapy does not fill me with confidence, come back when there are actual results.
     
  10. Xaser94

    Xaser94 Established Member

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    Since ppl from the blogs referenced this thread Im going to continue to update it with info I can find.

    https://www.prbuzz.com/technology/3...patent-application.html#.V32C1M8Jg5A.linkedin


    Howard J. Leonhardt the Founder, Executive Chairman and CEO of HairCell and Dr. Jorge Genovese a collaborative researcher from Buenos Aires, Argentina are co-inventors of this product. Howard Leonhardt previously patented a series of stem cell delivery and electrical stimulation devices and signals for homing stem cells to targeted tissues starting in 1995. Dr. Genovese has been conducting electrical stimulation based regeneration research for over twenty years with numerous published peer reviewed papers.

    "We believe the HairCell bioelectric stimulator with 10 unique controlled on demand protein expression signals combined with our HC-15 proprietary 15 component hair regeneration composition delivered via our patented micro infusion pump is destined to out perform all other technologies tried to date for hair regeneration. We are set to implement now well designed controlled clinical trials to prove out this claim. " stated Derek Kahn, HairCell President and lead investor.

    "Numerous published papers, including a number from our own labs, have documented the powerful ability of our stimulated proteins and delivered cell based composition components to promote tissue regeneration. Until now there was not a practical, safe and cost effective method of controlled delivery of all these beneficial proteins applied to hair regeneration in one combined system. Our technology is the first with refined bioelectric signals that communicate with the DNA of cells to program them to release specific regeneration promotion proteins on demand." Stated Dr. Jorge Genovese Co-Inventor


    The supporting scientific articles Dr. Genovese mentioned may be reached via this link - http://leonhardtventures.com/haircell/#toggle-id-1
     
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