Does anyone know if S5 cream works? I have read very conflicting viewpoints and the @Admin here seems to promote its use. I wouldn't mind adding this to my minoxidil regimen if it's save and effective.... and it has a legit source of purchase so I know I'm getting the active ingredient. Thoughts??
Great Success Without Using Aa's, But....
- Thread starter Pavi
- Start date
- Reaction score
- 948
Confused about "conflicting viewpoints". The only viewpoints that matter are what are found in studies. Everything else are random dudes on the internet pretending they are chemists / biologists / dermatologists. 
When it comes to hair loss treatments, opinions really mean nothing. Data is what matters - either on the product itself or its ingredients. Topical Spironolactone has been used for topical antiandrogen treatment for both hair loss and acne for decades.
Its not some random new product that is subject to online randoms saying it might or might not be legit. It is legit. Its about as legit as legit can get outside of taking Propecia.
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https://www.researchgate.net/public...ronolactone_therapies_in_skin_androgenization
“The most important clinical studies using spironolactone as an antiandrogen drug either per os or topically are referred. Menstrual disturbances very often occur during SP treatments thus limiting its systemic use. As far as the topical use is concerned SP seems to be highly effective with absence of systemic effects. Local mild side effects were present in a small number of patients.”
Spironolactone has been used topically by acne sufferers for decades for the exact same reason it would be beneficial for hair loss. Local inhibition of androgen activity in the skin.
From wikipedia:
“Spironolactone is an antagonist of the androgen receptor (AR) as well as an inhibitor of androgen production. Due to the antiandrogenic effects that result from these actions, it is frequently used off-label to treat a variety of dermatological conditions in which androgens, such as testosterone and dihydrotestosterone (DHT), play a role. Some of these uses include androgenic alopecia in men (either at low doses or as a topical formulation) and women, and hirsutism, acne, and seborrhea in women.[16] Spironolactone is the most commonly used drug in the treatment of hirsutism in the United States.[17]”
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When it comes to hair loss treatments, opinions really mean nothing. Data is what matters - either on the product itself or its ingredients. Topical Spironolactone has been used for topical antiandrogen treatment for both hair loss and acne for decades.
Its not some random new product that is subject to online randoms saying it might or might not be legit. It is legit. Its about as legit as legit can get outside of taking Propecia.
-----
https://www.researchgate.net/public...ronolactone_therapies_in_skin_androgenization
“The most important clinical studies using spironolactone as an antiandrogen drug either per os or topically are referred. Menstrual disturbances very often occur during SP treatments thus limiting its systemic use. As far as the topical use is concerned SP seems to be highly effective with absence of systemic effects. Local mild side effects were present in a small number of patients.”
Spironolactone has been used topically by acne sufferers for decades for the exact same reason it would be beneficial for hair loss. Local inhibition of androgen activity in the skin.
From wikipedia:
“Spironolactone is an antagonist of the androgen receptor (AR) as well as an inhibitor of androgen production. Due to the antiandrogenic effects that result from these actions, it is frequently used off-label to treat a variety of dermatological conditions in which androgens, such as testosterone and dihydrotestosterone (DHT), play a role. Some of these uses include androgenic alopecia in men (either at low doses or as a topical formulation) and women, and hirsutism, acne, and seborrhea in women.[16] Spironolactone is the most commonly used drug in the treatment of hirsutism in the United States.[17]”
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- Reaction score
- 5,210
Confused about "conflicting viewpoints". The only viewpoints that matter are what are found in studies. Everything else are random dudes on the internet pretending they are chemists / biologists / dermatologists.
When it comes to hair loss treatments, opinions really mean nothing. Data is what matters - either on the product itself or its ingredients. Topical Spironolactone has been used for topical antiandrogen treatment for both hair loss and acne for decades.
Its not some random new product that is subject to online randoms saying it might or might not be legit. It is legit. Its about as legit as legit can get outside of taking Propecia.
-----
https://www.researchgate.net/public...ronolactone_therapies_in_skin_androgenization
“The most important clinical studies using spironolactone as an antiandrogen drug either per os or topically are referred. Menstrual disturbances very often occur during SP treatments thus limiting its systemic use. As far as the topical use is concerned SP seems to be highly effective with absence of systemic effects. Local mild side effects were present in a small number of patients.”
Spironolactone has been used topically by acne sufferers for decades for the exact same reason it would be beneficial for hair loss. Local inhibition of androgen activity in the skin.
From wikipedia:
“Spironolactone is an antagonist of the androgen receptor (AR) as well as an inhibitor of androgen production. Due to the antiandrogenic effects that result from these actions, it is frequently used off-label to treat a variety of dermatological conditions in which androgens, such as testosterone and dihydrotestosterone (DHT), play a role. Some of these uses include androgenic alopecia in men (either at low doses or as a topical formulation) and women, and hirsutism, acne, and seborrhea in women.[16] Spironolactone is the most commonly used drug in the treatment of hirsutism in the United States.[17]”
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yup! I am sure it works as well as like RU or something. The before and after results for each are overwhelming!!
- Reaction score
- 11,939
yup! I am sure it works as well as like RU or something. The before and after results for each are overwhelming!!
There are before and after results for RU as has been pointed out many times.
It didn't work for you but somehow you have AA receptor upregulation, something which many people on this forum have but the medical community regards as not existing.
Either way, it's rare and for you guys AA are off-limits.
- Reaction score
- 5,210
I don't think this reaction to AA's can be classified as "rare". MOST of the people on here that regularly use RU see absolutely no results at all. Every day we have more and more people coming on here talking about how even finasteride is either not working or causing Telogen Effluvium, or upregulation. Obviously, I really am not bitter about finasteride, I would recommend it to anyone with hair loss. I just think the possibility of it not working should be considered much greater than 1% or whatever...
- Reaction score
- 948
Opinions versus hair counts. I wish we could actually have hair counts to work with on our own scalps, because I'll tell you one thing - I would've sworn on my mothers life that Propecia made me lose hair for 11 straight months.
It took that long for me to see things turn around and new hairs to start sprouting up. Imagine the # of guys who come to the forums during that 11 months and post that "propecia sucks and doesnt work" and stopped taking it before it did work?
I've learned to put very little stock in what people write on forums.
You can't know if they've adhered to the regimen. You can't know if they're just having a bad hair day, or have problems with "perception" in general. There's literally no way to know anything. That's why studies are the only thing that matters, along with crossing your fingers that you're in the "responsive" group.
You're right. As per the FDA trials, only 83% saw success on it. That means 17% of people did not see increased or maintained hair counts. But this has been known for a long time.
Admin
Yeah except these studies failed to account for AR upregulation. Technically all the 17% could be worse off by taking finasteride than by taking nothing at all. I have heard many people, including doctors, say that even if you're continuing to lose hair on finasteride, it is slowing down your loss. Studies do not show this, and this could be completely false. If you are a "non-responder" to finasteride it could very well be doing much more harm than good.
Also can you please post a study on topical spironolactone's effectiveness for hair loss? I've never seen one.
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