- Reaction score
- 950
@InBeforeTheCure,
Nice post dude. I'll respond later with some studies. Meanwhile have you looked into estrogen action on the hair follicle? As we know castration + estrogen is pretty much the only thing that can sometimes but not always grow back a considerate amount of hair. I like to quote Cotsarelis in this;
Anyway about estrogen, here are two in depth studies; http://press.endocrine.org/doi/full/10.1210/er.2006-0020, http://elib.tiho-hannover.de/dissertations/conradf_ss04.pdf. Curious to your opinion!
I went and cross-referenced the genes mentioned in that first paper with the genes from a paper that looked at gene expression differences between DPCs in balding vs. non-balding scalp.
Here's the list with their abbreviated names:
Code:
[TABLE="width: 128"]
[TR]
[TD="class: xl63, width: 64"]Gene[/TD]
[TD="class: xl63, width: 64"]Level[/TD]
[/TR]
[TR]
[TD]DNPH1[/TD]
[TD="align: right"]10.75[/TD]
[/TR]
[TR]
[TD]CASP4[/TD]
[TD="align: right"]10.38[/TD]
[/TR]
[TR]
[TD]MOG[/TD]
[TD="align: right"]9.23[/TD]
[/TR]
[TR]
[TD]CDKN2B[/TD]
[TD="align: right"]8.38[/TD]
[/TR]
[TR]
[TD]ICAM1[/TD]
[TD="align: right"]6.95[/TD]
[/TR]
[TR]
[TD]PSMA2[/TD]
[TD="align: right"]6.78[/TD]
[/TR]
[TR]
[TD]PMP22[/TD]
[TD="align: right"]6.34[/TD]
[/TR]
[TR]
[TD]PPP1CA[/TD]
[TD="align: right"]6.21[/TD]
[/TR]
[TR]
[TD]TFDP1[/TD]
[TD="align: right"]6.06[/TD]
[/TR]
[TR]
[TD]TPH2[/TD]
[TD="align: right"]5.34[/TD]
[/TR]
[TR]
[TD]TMF1[/TD]
[TD="align: right"]4.89[/TD]
[/TR]
[TR]
[TD]PKD1[/TD]
[TD="align: right"]3.68[/TD]
[/TR]
[TR]
[TD]AKT1[/TD]
[TD="align: right"]3.55[/TD]
[/TR]
[TR]
[TD]PAX5[/TD]
[TD="align: right"]3.45[/TD]
[/TR]
[TR]
[TD]GSTT1[/TD]
[TD="align: right"]3.38[/TD]
[/TR]
[TR]
[TD]DCN[/TD]
[TD="align: right"]2.94[/TD]
[/TR]
[TR]
[TD]SULT1E1[/TD]
[TD="align: right"]2.88[/TD]
[/TR]
[TR]
[TD]ITGAV[/TD]
[TD="align: right"]2.86[/TD]
[/TR]
[TR]
[TD]STAT1[/TD]
[TD="align: right"]2.69[/TD]
[/TR]
[TR]
[TD]CDK10[/TD]
[TD="align: right"]2.51[/TD]
[/TR]
[TR]
[TD]TAF9[/TD]
[TD="align: right"]2.38[/TD]
[/TR]
[TR]
[TD]NTF4[/TD]
[TD="align: right"]2.34[/TD]
[/TR]
[TR]
[TD]CDK5[/TD]
[TD="align: right"]2.27[/TD]
[/TR]
[TR]
[TD]HSPA72[/TD]
[TD="align: right"]2.22[/TD]
[/TR]
[TR]
[TD]PSME2[/TD]
[TD="align: right"]2.19[/TD]
[/TR]
[TR]
[TD]TMSB4X[/TD]
[TD="align: right"]2.02[/TD]
[/TR]
[TR]
[TD]RAD23A[/TD]
[TD="align: right"]1.93[/TD]
[/TR]
[TR]
[TD]MLH1[/TD]
[TD="align: right"]1.81[/TD]
[/TR]
[TR]
[TD]ROBO1[/TD]
[TD="align: right"]1.71[/TD]
[/TR]
[TR]
[TD]PRDX2[/TD]
[TD="align: right"]1.61[/TD]
[/TR]
[TR]
[TD]ZYX[/TD]
[TD="align: right"]1.6[/TD]
[/TR]
[TR]
[TD]MNAT1[/TD]
[TD="align: right"]1.57[/TD]
[/TR]
[TR]
[TD]DNASE2[/TD]
[TD="align: right"]1.52[/TD]
[/TR]
[TR]
[TD]GSS[/TD]
[TD="align: right"]1.51[/TD]
[/TR]
[TR]
[TD]HLA-C[/TD]
[TD="align: right"]1.47[/TD]
[/TR]
[TR]
[TD]DDIT3[/TD]
[TD="align: right"]1.44[/TD]
[/TR]
[TR]
[TD]COMT[/TD]
[TD="align: right"]1.32[/TD]
[/TR]
[TR]
[TD]TIMP2[/TD]
[TD="align: right"]0.8[/TD]
[/TR]
[TR]
[TD]MCL1[/TD]
[TD="align: right"]0.79[/TD]
[/TR]
[TR]
[TD]IL6[/TD]
[TD="align: right"]0.74[/TD]
[/TR]
[TR]
[TD]TYRO3[/TD]
[TD="align: right"]0.69[/TD]
[/TR]
[TR]
[TD]GPX2[/TD]
[TD="align: right"]0.65[/TD]
[/TR]
[TR]
[TD]RHOB[/TD]
[TD="align: right"]0.65[/TD]
[/TR]
[TR]
[TD]VEGFC[/TD]
[TD="align: right"]0.64[/TD]
[/TR]
[TR]
[TD]EZR[/TD]
[TD="align: right"]0.61[/TD]
[/TR]
[TR]
[TD]ACTB[/TD]
[TD="align: right"]0.59[/TD]
[/TR]
[TR]
[TD]NUCB1[/TD]
[TD="align: right"]0.59[/TD]
[/TR]
[TR]
[TD]CDK6[/TD]
[TD="align: right"]0.58[/TD]
[/TR]
[TR]
[TD]MCAM[/TD]
[TD="align: right"]0.57[/TD]
[/TR]
[TR]
[TD]PURA[/TD]
[TD="align: right"]0.57[/TD]
[/TR]
[TR]
[TD]FGR[/TD]
[TD="align: right"]0.56[/TD]
[/TR]
[TR]
[TD]MAPK3[/TD]
[TD="align: right"]0.55[/TD]
[/TR]
[TR]
[TD]MAPKAPK2[/TD]
[TD="align: right"]0.54[/TD]
[/TR]
[TR]
[TD]PTMS[/TD]
[TD="align: right"]0.54[/TD]
[/TR]
[TR]
[TD]ARHGDIA[/TD]
[TD="align: right"]0.51[/TD]
[/TR]
[TR]
[TD]COL4A2[/TD]
[TD="align: right"]0.51[/TD]
[/TR]
[TR]
[TD]CAPN2[/TD]
[TD="align: right"]0.5[/TD]
[/TR]
[TR]
[TD]RAB5A[/TD]
[TD="align: right"]0.49[/TD]
[/TR]
[TR]
[TD]ID2[/TD]
[TD="align: right"]0.48[/TD]
[/TR]
[TR]
[TD]IL4[/TD]
[TD="align: right"]0.48[/TD]
[/TR]
[TR]
[TD]CTGF[/TD]
[TD="align: right"]0.47[/TD]
[/TR]
[TR]
[TD]KRAS[/TD]
[TD="align: right"]0.47[/TD]
[/TR]
[TR]
[TD]MYC[/TD]
[TD="align: right"]0.46[/TD]
[/TR]
[TR]
[TD]MYBL1[/TD]
[TD="align: right"]0.44[/TD]
[/TR]
[TR]
[TD]RBL2[/TD]
[TD="align: right"]0.44[/TD]
[/TR]
[TR]
[TD]TIAM1[/TD]
[TD="align: right"]0.44[/TD]
[/TR]
[TR]
[TD]CCND1[/TD]
[TD="align: right"]0.43[/TD]
[/TR]
[TR]
[TD]CTTN[/TD]
[TD="align: right"]0.43[/TD]
[/TR]
[TR]
[TD]TNFAIP2[/TD]
[TD="align: right"]0.41[/TD]
[/TR]
[TR]
[TD]PSMF1[/TD]
[TD="align: right"]0.37[/TD]
[/TR]
[TR]
[TD]TGFB2[/TD]
[TD="align: right"]0.37[/TD]
[/TR]
[TR]
[TD]BDNF?[/TD]
[TD="align: right"]0.36[/TD]
[/TR]
[TR]
[TD]CDC25B[/TD]
[TD="align: right"]0.36[/TD]
[/TR]
[TR]
[TD]CYP1B1[/TD]
[TD="align: right"]0.34[/TD]
[/TR]
[TR]
[TD]NME1[/TD]
[TD="align: right"]0.34[/TD]
[/TR]
[TR]
[TD]RAF1[/TD]
[TD="align: right"]0.33[/TD]
[/TR]
[TR]
[TD]RARB[/TD]
[TD="align: right"]0.33[/TD]
[/TR]
[TR]
[TD]CDH11[/TD]
[TD="align: right"]0.32[/TD]
[/TR]
[TR]
[TD]CXCL5[/TD]
[TD="align: right"]0.31[/TD]
[/TR]
[TR]
[TD]FLT3[/TD]
[TD="align: right"]0.31[/TD]
[/TR]
[TR]
[TD]RALA[/TD]
[TD="align: right"]0.29[/TD]
[/TR]
[TR]
[TD]PPP3CA[/TD]
[TD="align: right"]0.28[/TD]
[/TR]
[TR]
[TD]GSTA2[/TD]
[TD="align: right"]0.27[/TD]
[/TR]
[TR]
[TD]AXL[/TD]
[TD="align: right"]0.26[/TD]
[/TR]
[TR]
[TD]MARK3[/TD]
[TD="align: right"]0.26[/TD]
[/TR]
[TR]
[TD]FOS[/TD]
[TD="align: right"]0.24[/TD]
[/TR]
[TR]
[TD]NRAS[/TD]
[TD="align: right"]0.24[/TD]
[/TR]
[TR]
[TD]CRABP2[/TD]
[TD="align: right"]0.21[/TD]
[/TR]
[TR]
[TD]ETS1[/TD]
[TD="align: right"]0.21[/TD]
[/TR]
[TR]
[TD]INHBA[/TD]
[TD="align: right"]0.2[/TD]
[/TR]
[TR]
[TD]ELK1[/TD]
[TD="align: right"]0.19[/TD]
[/TR]
[TR]
[TD]PIP5K1A[/TD]
[TD="align: right"]0.18[/TD]
[/TR]
[TR]
[TD]ETV6[/TD]
[TD="align: right"]0.17[/TD]
[/TR]
[TR]
[TD]IGFBP3[/TD]
[TD="align: right"]0.14[/TD]
[/TR]
[TR]
[TD]CCNB1[/TD]
[TD="align: right"]0.13[/TD]
[/TR]
[TR]
[TD]PIP4K2B[/TD]
[TD="align: right"]0.12[/TD]
[/TR]
[TR]
[TD]MPV17[/TD]
[TD="align: right"]0.09[/TD]
[/TR]
[TR]
[TD]SERPINA3[/TD]
[TD="align: right"]0.09[/TD]
[/TR]
[TR]
[TD]CRYZ[/TD]
[TD="align: right"]0.08[/TD]
[/TR]
[TR]
[TD]PIM1[/TD]
[TD="align: right"]0.08[/TD]
[/TR]
[TR]
[TD]NR2F6[/TD]
[TD="align: right"]0.06[/TD]
[/TR]
[TR]
[TD]BMP2[/TD]
[TD="align: right"]0.04[/TD]
[/TR]
[TR]
[TD]NR1D1[/TD]
[TD="align: right"]0.04[/TD]
[/TR]
[TR]
[TD]KSR1[/TD]
[TD="align: right"]0.02[/TD]
[/TR]
[TR]
[TD]EFNA3[/TD]
[TD="align: right"]0.01[/TD]
[/TR]
[TR]
[TD]POLA1[/TD]
[TD="align: right"]0.01[/TD]
[/TR]
[/TABLE]
Genes downregulated in balding DPCs that are also downregulated by estrogen: TGFB2, but they say that's in epithelial cells, so NONE really.
Genes upregulated in balding DPCs that are differentially regulated by estrogen: None
Interesting that VEGF, c-Fos, Cyclin D1, c-Myc, and BMP2 are all beta-catenin target genes* (I think). Bcl2 (not a beta-catenin target AFAIK) is also upregulated by estrogen, which protects against oxidative stress-induced apoptosis. Balding DPCs are under oxidative stress, as you know.
* Not exclusively beta-catenin targets, of course.
Swoop said:Note also that he says mast cells might contribute to hair loss but I'll get into that later. That's why I made a correlation, to me a increase of mast cells might automatically mean enhanced PGD2 levels as they are the biggest source of that.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319975/figure/F4/
I'm no good at interpreting stains, but to me it looks like most of the green Ptgds stained cells don't show any red tryptase staining? But I guess it depends on magnitude of expression as well.