inmyhead
Senior Member
- Reaction score
- 1,019
Warning! Mice study.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293257/#MOESM2
...Our findings show that GDNF promotes hair formation and cutaneous would healing in mice. Both recombinant and transgene overexpression of GDNF promoted BSC colony growth, hair formation, and skin repair after wounding, while genetic ablation of Ret within BSCs prevented the onset of the hair cycle, the anagen induction of depilated hair follicles, and reduced the rate of wound closure. GDNF has previously been suggested to play a role in the natural hair cycle, however its function within BSCs has never been tested. Our data show that GDNF protein is present predominantly within the interfollicular space and in the vicinity of sebaceous glands, while single-cell sequencing results from mouse skin reveal that Gdnf transcripts are present in both bulge hair follicle stem cells, as well as keratinocytes of the interfollicular epidermis (Joost et al. 2016), suggesting that GDNF could be acting on more than one cell type within the skin. GDNF and its receptor GFRA1 are also expressed in human skin and show an age dependent decline[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960578/]....
What increases it?
Calorie restriction – Significantly increases GDNF (along with other neurotrophic factors such as BDNF and neurotrophin-3) in the brain and gut nervous systems
Exercise – Exercise increases GDNF in the spinal cords of both young and old rats
Stress reduction – Stress negatively impacts GDNF levels, and avoiding it can be a great way to boost GDNF, along with many other health benefits
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293257/#MOESM2
...Our findings show that GDNF promotes hair formation and cutaneous would healing in mice. Both recombinant and transgene overexpression of GDNF promoted BSC colony growth, hair formation, and skin repair after wounding, while genetic ablation of Ret within BSCs prevented the onset of the hair cycle, the anagen induction of depilated hair follicles, and reduced the rate of wound closure. GDNF has previously been suggested to play a role in the natural hair cycle, however its function within BSCs has never been tested. Our data show that GDNF protein is present predominantly within the interfollicular space and in the vicinity of sebaceous glands, while single-cell sequencing results from mouse skin reveal that Gdnf transcripts are present in both bulge hair follicle stem cells, as well as keratinocytes of the interfollicular epidermis (Joost et al. 2016), suggesting that GDNF could be acting on more than one cell type within the skin. GDNF and its receptor GFRA1 are also expressed in human skin and show an age dependent decline[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960578/]....
What increases it?
Calorie restriction – Significantly increases GDNF (along with other neurotrophic factors such as BDNF and neurotrophin-3) in the brain and gut nervous systems
Exercise – Exercise increases GDNF in the spinal cords of both young and old rats
Stress reduction – Stress negatively impacts GDNF levels, and avoiding it can be a great way to boost GDNF, along with many other health benefits