Frontal thinning on Avodart

JWM

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Their are MANY reports from those using Dutasteride that the drug accelerated frontal thinning/loss.

I wonder if any on this site has experienced similar results?
 

Goingat20

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i have experienced frontal thinning which has continued to progress even while using dutasteride.
 

techprof

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on the contrary, I seem to respond better in the front for dutasteride, finasteride, minoxidil or sods. I chose not to put in grafts in the front for this reason.
 

demo99

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I can't imagine. What should be the reason of this symptom?

I allege:

"Dutasterid work more effective, because you have a higher DHT reduction"

Why should Dutasterid make a front front thinning?

best regards

demo99
 

CCS

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although bryan says he never saw such a study, I saw a study of about 100 men that showed that dutasteride at high doses worked worse in front than proscar, and better in back. I wish I could find it again. I can't even find the phaseII trials.
 

Sean68

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do you know what the dosage was? i want to stop my frontal thinning and ive just ordered dutas about 5 minutes ago! im hoping this study relates to dosages of more than 0.5mg.
 

CCS

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they tested 0.05, 0.1, 0.5, and 2.5mg/day dutasteride, and 5mg of proscar. 0.05mg/day did the worst in all areas. 0.1mg/day dutasteride was equal in every way to 5mg proscar, and 0.5 and 2.5mg/day regrow more hair overall, concentrated in back, but less hair in the temples than 5mg/day proscar.

I hope they were smart enough to use a similar percentage of NW2's and 5's to get an accurate comparision. The results make no sense to me. Maybe the hair in the temples is more similar to facial hair, and needs a small amount of androgens, but even that does not make sense because propecia should make it thrive more than the back, then. I don't know. I highly doubt taking dutasteride and finasteride at the same time would help. It would just be like taking more dutasteride. I'm just going to take the dutasteride and assume the experimentors made a mistake somewhere.
 

Bryan

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collegechemistrystudent said:
although bryan says he never saw such a study, I saw a study of about 100 men that showed that dutasteride at high doses worked worse in front than proscar, and better in back. I wish I could find it again.

I can't imagine what it is you saw. I'm almost positive that the ONLY trial that's ever been done on dutasteride for hairloss was Glaxo's. If there were a second one, it would be the talk of all the hairloss forums.

Bryan
 

Bryan

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collegechemistrystudent said:
they tested 0.05, 0.1, 0.5, and 2.5mg/day dutasteride, and 5mg of proscar. 0.05mg/day did the worst in all areas. 0.1mg/day dutasteride was equal in every way to 5mg proscar, and 0.5 and 2.5mg/day regrow more hair overall, concentrated in back, but less hair in the temples than 5mg/day proscar.

Are you referring to Glaxo's trial?? They didn't test hair in the temples. Just the vertex.

Bryan
 

CCS

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I don't know what I saw, but I can't even find Glaxo's results on google. All I can find are DHT inhibition results under the phaseII title.
 

Jacky81

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I am in month 8 using dutasteride daily. My front did perhaps shedd in some periods but i cannot imagine that dutasteride does fasten the frontal loss.
My front seems to thicken slowly again and the hairline seems to walk back to the forehead, but all happens slowly and the (new) hair is still thin.

But i have great hopes and i think also good chances.
 

powersam

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some have suggested its because of the 104% rise in testosterone in the scalp at 0.5mg dutasteride a day. though this sounds attractive, you'd still have less dht so you shouldnt be shedding. maybe hair at the front is more susceptible to test?
 

MPBWarrior

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Testosterone is an androgen and the increased testosterone from such reduced DHT-levels seems to affect the hairline. Therefore if you´re using dutasteride, u should also be using a topical anti-androgen.
 

powersam

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mpbwarrior - we know dht affects follicles more than T , so if we decrease dht for a similar increase in T we should still be ahead of the game rather than behind.
 

JWM

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maybe hair at the front is more susceptible to test?

That's a popular theory.
 

CCS

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it has me worried to. If the samples pass the test, I will risk my money buying 20 strips for the discount, but won't risk my hair. When I test every other box and am sure to test every lot number, then I will feel save with my hair for those. But that does not help everyone else here on this site. While it may indicate to them that the stuff is real, they still will wonder if it changes month to month. And the next time I buy 20, I'm testing them again.
 

Jacky81

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dutasteride users have more testosterone...ok.
But testosterone doesn not destroy the hair folicles, only dht. And dutasteride does block dht - so why should more testosterone be a problem?
 

CCS

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all androgens contribute to hair loss, even other steroids. DHT is by far the strongest contributer, though testosterone does also to a lessor extent.

5ar blockers are good because it is better to fight a weak enemy than a strong one.
 
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