Flutagel vs 5 % spironolactone
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abovedagame
Experienced Member
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considering the fact that sinere no longer sells flutagel...i dont think it matters 
At least with women, studies indicate that the effects of topical flutamide are due to systemic absorbtion. BTW, the same is apparently true of topical finasteride.
So you might as well take it by mouth, although I cannot recommend that-- too many side-effects and it likely works little if any better than finasteride. Because of reflex hyperandrogenicity, it is necessary to castrate males taking this drug for prostate cancer to get longer-term effects.
My favorite antiandrogens are topical spironolactone or systemic finasteride. While on paper, spironolactone is much the stronger antiandrogen, as a practical matter it probably works little if any better on hair loss than systemic finasteride. Its chief advantage seems to lack of side-effects since spironlactone is not absorbed systemically from topical application.
Peter H. Proctor, PhD,MD
So you might as well take it by mouth, although I cannot recommend that-- too many side-effects and it likely works little if any better than finasteride. Because of reflex hyperandrogenicity, it is necessary to castrate males taking this drug for prostate cancer to get longer-term effects.
My favorite antiandrogens are topical spironolactone or systemic finasteride. While on paper, spironolactone is much the stronger antiandrogen, as a practical matter it probably works little if any better on hair loss than systemic finasteride. Its chief advantage seems to lack of side-effects since spironlactone is not absorbed systemically from topical application.
Peter H. Proctor, PhD,MD
treadstone
Established Member
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Dr. Proctor, do you have any reason to believe that topical spironolactone when applied to the skin may have some degree of dispersion such that neighboring areas not directly in contact with the topical will be subject to its antiandrogenic effects?