As once cassin suggested, is good to collect here all possible study on finasteride. it's a hard task but it's worth trying
I start with copy/paste from PH then i will integrate with new ones
i encourage also another one that will provide positive studies possibly all in one post. we can integrate it everytimes we found new ones
it's only a raw random start.
-------------------------------------------------------------------
Effect of finasteride on human testicular steroidogenesis
http://www.andrologyjournal.org/cgi/con ... t/17/5/516
----------------------------------------------------------------
Finasteride-induced myalgia and HyperCKemia. http://www.ncbi.nlm.nih.gov/pubmed/19169095
-------------------------------------------------------------------
Finasteride and acquired androgen insensitivity
Acquired androgen insensitivity may occur without AR mutations by mechanisms such as drugs including non-steroidal (flutamide, bicalutamide, nilutamide) and steroidal (cyproterone acetate), drugs that block part of testosterone activation such as 5? reductase inhibitors (finasteride, dutasteride) or estrogen antagonists or aromatase inhibitors.
In addition, drugs may have physiological effects or pharmacological actions that oppose various steps in androgen action such as LH and FSH suppression by estrogens or progestins or that cause an increase in circulating SHBG which may influence testosterone transfer from blood into tissues to produce a functional phenocopy of androgen insensitivity.
http://www.endotext.org/male/male2/male2.htm
-----------------------------------------------------
Finasteride-induced Acute Hepatitis (Kunizawa A)
Conclusion: To our best knowledge, this is the first report of the Androgenetic Alopecia case associated with finasteride-induced acute hepatitis. We deduce that finasteride may cause the hepatic cell damage by an allergic reaction mechanism.
http://www.asiatox.org/6th%20APAMT%20pd ... atitis.pdf
-------------------------------------------------------
TRANSGENDERCARE MEDICAL FEMINIZING PROGRAM
(FINA included)
http://www.transgendercare.com/medical/ ... gimens.asp
-----------------------------------
FINASTERIDE PANCREATITIS
Finasteride: First report of acute pancreatitis: case report
http://www.ingentaconnect.com/content/a ... 9/art00027
Acute pancreatitis possibly related to finasteride.
http://www.ncbi.nlm.nih.gov/sites/entre ... xed=google
Drug-induced pancreatitis
http://www.pharmacists.ca/content/cpjpd ... tookhy.pdf
-- See page 2, lower right of table under "miscellaneous" category... Finasteride is listed.
Here is another article detailing increased risk of pancreatitis in Proscar users:
http://journals.lww.com/jcge/Abstract/2 ... of.15.aspx
----------------------------------------------------------------------------------------------
Castration-like effects on the human prostate of a 5-reductase inhibitor, finasteride
If the acute effects of finasteride on tissue T and DHT persist during chronic therapy, prostatic hormone concentrations could be said to closely resemble those found following surgical castration; such changes might prevent the occurrence of prostate cancer, similar to the effects noted after surgical castration in younger males.
http://onlinelibrary.wiley.com/doi/10.1 ... 5/abstract
----------------------------------------------------------------------
Incidence and severity of sexual adverse experiences in finasteride and placebo-treated men with benign prostatic hyperplasia.
CONCLUSIONS:
Compared with placebo, men treated with finasteride experienced new drug-related sexual AEs with an increased incidence only during the first year of therapy.
http://www.ncbi.nlm.nih.gov/entrez/quer ... med_DocSum
------------------------------------------------
Evidence for atrophy and apoptosis in the ventral prostate of rats
given the 5 alpha-reductase inhibitor finasteride.
FULL TEXT:
http://endo.endojournals.org/cgi/reprint/136/2/741.pdf
-------------------------------------------------------------------------
Erectile dysfunction following treatments of benign prostatic hyperplasia: a prospective study.
http://www.ncbi.nlm.nih.gov/entrez/quer ... med_docsum
------------------------------------------------------------------------------
Effect of selective 5alpha-reductase inhibitor or/and testosterone undecanoate on the reproductive function of male rats
CONCLUSION:
High dosages of 5alpha-reductase inhibitor, Finasteride, can suppress male reproductive function, but the inhibiting effect could be counteracted by administration of 5alpha-reductase inhibitor along with TU.
http://www.ncbi.nlm.nih.gov/entrez/quer ... med_DocSum
-------------------------------------------------------------------------
Actions of 5alpha-reductase inhibitors on the epididymis.
Two isozymes of 5alpha-reductase, types 1 and 2, are abundantly expressed in the epididymis. DHT is the androgen found in the nuclei of epididymal cells and is essential for the maturation of spermatozoa. Thus, one approach to block androgen action in the epididymis is to inhibit DHT formation.
Several compounds have been reported to inhibit either one or both forms of 5alpha-reductase in many tissues. The first commercially available inhibitor of 5alpha-reductase, finasteride, has a predominant effect on the type 2 isozyme, while more recently developed agents, such as dutasteride, PNU157706 and FK143, act as dual inhibitors.
We found that the treatment of adult rats with such agents results in pronounced effects on the expression of genes essential to the formation of the optimal luminal microenvironment that is required for proper sperm maturation.
Furthermore, drug treatment caused a significant decrease in the percentage of progressively motile and morphologically normal spermatozoa in the cauda epididymides.
Mating females to treated males resulted in fewer successful pregnancies and a higher rate of pre-implantation loss. Thus, there may be a role for dual 5alpha-reductase inhibitors as potential components of a male contraceptive.
http://www.ncbi.nlm.nih.gov/entrez/quer ... med_DocSum
--------------------------------------------------------------------------------------
androgen insensitivity
Acquired androgen insensitivity may occur without AR mutations by mechanisms such as drugs including non-steroidal (flutamide, bicalutamide, nilutamide) and steroidal (cyproterone acetate), drugs that block part of testosterone activation such as 5? reductase inhibitors (finasteride, dutasteride) or estrogen antagonists or aromatase inhibitors.
In addition, drugs may have physiological effects or pharmacological actions that oppose various steps in androgen action such as LH and FSH suppression by estrogens or progestins or that cause an increase in circulating SHBG which may influence testosterone transfer from blood into tissues to produce a functional phenocopy of androgen insensitivity.
http://www.endotext.org/male/male2/male2.htm
I start with copy/paste from PH then i will integrate with new ones
i encourage also another one that will provide positive studies possibly all in one post. we can integrate it everytimes we found new ones
it's only a raw random start.
-------------------------------------------------------------------
Effect of finasteride on human testicular steroidogenesis
http://www.andrologyjournal.org/cgi/con ... t/17/5/516
----------------------------------------------------------------
Finasteride-induced myalgia and HyperCKemia. http://www.ncbi.nlm.nih.gov/pubmed/19169095
-------------------------------------------------------------------
Finasteride and acquired androgen insensitivity
Acquired androgen insensitivity may occur without AR mutations by mechanisms such as drugs including non-steroidal (flutamide, bicalutamide, nilutamide) and steroidal (cyproterone acetate), drugs that block part of testosterone activation such as 5? reductase inhibitors (finasteride, dutasteride) or estrogen antagonists or aromatase inhibitors.
In addition, drugs may have physiological effects or pharmacological actions that oppose various steps in androgen action such as LH and FSH suppression by estrogens or progestins or that cause an increase in circulating SHBG which may influence testosterone transfer from blood into tissues to produce a functional phenocopy of androgen insensitivity.
http://www.endotext.org/male/male2/male2.htm
-----------------------------------------------------
Finasteride-induced Acute Hepatitis (Kunizawa A)
Conclusion: To our best knowledge, this is the first report of the Androgenetic Alopecia case associated with finasteride-induced acute hepatitis. We deduce that finasteride may cause the hepatic cell damage by an allergic reaction mechanism.
http://www.asiatox.org/6th%20APAMT%20pd ... atitis.pdf
-------------------------------------------------------
TRANSGENDERCARE MEDICAL FEMINIZING PROGRAM
(FINA included)
http://www.transgendercare.com/medical/ ... gimens.asp
-----------------------------------
FINASTERIDE PANCREATITIS
Finasteride: First report of acute pancreatitis: case report
http://www.ingentaconnect.com/content/a ... 9/art00027
Acute pancreatitis possibly related to finasteride.
http://www.ncbi.nlm.nih.gov/sites/entre ... xed=google
Drug-induced pancreatitis
http://www.pharmacists.ca/content/cpjpd ... tookhy.pdf
-- See page 2, lower right of table under "miscellaneous" category... Finasteride is listed.
Here is another article detailing increased risk of pancreatitis in Proscar users:
http://journals.lww.com/jcge/Abstract/2 ... of.15.aspx
----------------------------------------------------------------------------------------------
Castration-like effects on the human prostate of a 5-reductase inhibitor, finasteride
If the acute effects of finasteride on tissue T and DHT persist during chronic therapy, prostatic hormone concentrations could be said to closely resemble those found following surgical castration; such changes might prevent the occurrence of prostate cancer, similar to the effects noted after surgical castration in younger males.
http://onlinelibrary.wiley.com/doi/10.1 ... 5/abstract
----------------------------------------------------------------------
Incidence and severity of sexual adverse experiences in finasteride and placebo-treated men with benign prostatic hyperplasia.
CONCLUSIONS:
Compared with placebo, men treated with finasteride experienced new drug-related sexual AEs with an increased incidence only during the first year of therapy.
http://www.ncbi.nlm.nih.gov/entrez/quer ... med_DocSum
------------------------------------------------
Evidence for atrophy and apoptosis in the ventral prostate of rats
given the 5 alpha-reductase inhibitor finasteride.
FULL TEXT:
http://endo.endojournals.org/cgi/reprint/136/2/741.pdf
-------------------------------------------------------------------------
Erectile dysfunction following treatments of benign prostatic hyperplasia: a prospective study.
http://www.ncbi.nlm.nih.gov/entrez/quer ... med_docsum
------------------------------------------------------------------------------
Effect of selective 5alpha-reductase inhibitor or/and testosterone undecanoate on the reproductive function of male rats
CONCLUSION:
High dosages of 5alpha-reductase inhibitor, Finasteride, can suppress male reproductive function, but the inhibiting effect could be counteracted by administration of 5alpha-reductase inhibitor along with TU.
http://www.ncbi.nlm.nih.gov/entrez/quer ... med_DocSum
-------------------------------------------------------------------------
Actions of 5alpha-reductase inhibitors on the epididymis.
Two isozymes of 5alpha-reductase, types 1 and 2, are abundantly expressed in the epididymis. DHT is the androgen found in the nuclei of epididymal cells and is essential for the maturation of spermatozoa. Thus, one approach to block androgen action in the epididymis is to inhibit DHT formation.
Several compounds have been reported to inhibit either one or both forms of 5alpha-reductase in many tissues. The first commercially available inhibitor of 5alpha-reductase, finasteride, has a predominant effect on the type 2 isozyme, while more recently developed agents, such as dutasteride, PNU157706 and FK143, act as dual inhibitors.
We found that the treatment of adult rats with such agents results in pronounced effects on the expression of genes essential to the formation of the optimal luminal microenvironment that is required for proper sperm maturation.
Furthermore, drug treatment caused a significant decrease in the percentage of progressively motile and morphologically normal spermatozoa in the cauda epididymides.
Mating females to treated males resulted in fewer successful pregnancies and a higher rate of pre-implantation loss. Thus, there may be a role for dual 5alpha-reductase inhibitors as potential components of a male contraceptive.
http://www.ncbi.nlm.nih.gov/entrez/quer ... med_DocSum
--------------------------------------------------------------------------------------
androgen insensitivity
Acquired androgen insensitivity may occur without AR mutations by mechanisms such as drugs including non-steroidal (flutamide, bicalutamide, nilutamide) and steroidal (cyproterone acetate), drugs that block part of testosterone activation such as 5? reductase inhibitors (finasteride, dutasteride) or estrogen antagonists or aromatase inhibitors.
In addition, drugs may have physiological effects or pharmacological actions that oppose various steps in androgen action such as LH and FSH suppression by estrogens or progestins or that cause an increase in circulating SHBG which may influence testosterone transfer from blood into tissues to produce a functional phenocopy of androgen insensitivity.
http://www.endotext.org/male/male2/male2.htm
