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Carbon disulfide: Carbon disulfide is good fat-soluble, it is easily absorbed through the lungs and skin. Prolonged exposure leads to symptoms of intoxication: Coronary heart disease, retinal angiopathy, color discrimination, effects on peripheral nerves, psychophysiological effects, morphological and other central nervous system (CNS) effects, and fertility and hormonal effects. Decreased libido and or impotence among males occupationally exposed to high concentrations of carbon disulfide. Menstrual disorders are more frequent than in the case of the healthy women, the average menopausal age is statistically earlier, and complex disturbances in neurohormonal system including diminished secretion of estrogens and progesterone in ovaries and dehydroepiandrosterone sulfate in the adrenal gland. DNA damage in human buccal cells of workers occupationally long-term exposed to carbon disulfide was monitored with comet assay, and the possibility of DNA damage was significantly higher in exposure group than that in control group. In human sperm exposed to carbon disulfide in vitro, there was a significant increase in the frequency of chromosomal aberrations and in the frequency of chromosomal breaks. DNA damage in mice sperm was detected. In experimental animals, carbon disulfide is embryotoxic and fetotoxic at high concentrations and is teratogenic at exposure levels toxic to the dam. Reduced hatching and developmental effects, particularly notochord deformities, were observed in the frog Microhyla ornata exposed to carbon disulfide. Neurological effects such as hind-limb motor difficulties, reduced nerve conduction velocity, and degeneration of nerve fibers were seen in rats exposed to 700 ppm of carbon disulfide for 5 hours a day, 5 days a week, for 12 weeks. Other behavioral effects in rats included decreased responsiveness to a visual stimulus and mild tremors, reactivity in response to handling was increased, and excitability in the open field was decreased.24-25
(2) (PDF) Coffee and Hereditary Hair Loss The End of The Story. Available from:
https://www.researchgate.net/public...and_Hereditary_Hair_Loss_The_End_of_The_Story [accessed Sep 10 2021].
Cresol: Cresols is good fat-soluble, it is easily absorbed through the lungs and skin. Cresol can be perceived as odorous even in concentrations of a few micrograms per cubic meter of air. Contaminated open mucous membranes (oral cavity, nose, anus) they go directly into the blood, where they are rapidly distributed in the body and lead to multiple protein damage to the internal organs. Poisoning causes quite unspecific symptoms. Signs of chronic poisoning include headache, cough and nausea, loss of appetite, and dullness and insomnia. Acute poisoning with kidney damage and central nervous system disorders such as seizures, unconsciousness and respiratory paralysis can be the result. Cresols are considered carcinogenic. Phenols and especially cresols have a strong protein decomposition. Because they are highly corrosive, they cause acute skin damage on contact with the skin, destroy the protein of the skin cells and overcome the protective mechanism of the skin, which is slightly acidic, almost immediately. In mice exposed to a mixture of o-cresol aerosol and vapor 2 hr/day, 6 days/week for 1 month no mortality was recorded. Clinical signs of toxicity during the daily exposure periods were limited to signs of respiratory 13
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irritation at the start of the exposure, followed by a period of hypoactivity lasting until the end of the exposure. Microscopic examination revealed signs of irritation in the respiratory tract. Other lesions included degeneration of heart muscle, liver, kidney and nerve cells and glial elements of the central nervous system. Hair depigmentation and microscopic effects on hair and skin biopsies. Repeats rough coat in experimental animals. Without immediate initiation of countermeasures, cresols can have a life-threatening effect even in small quantities.26-27
(2) (PDF) Coffee and Hereditary Hair Loss The End of The Story. Available from:
https://www.researchgate.net/public...and_Hereditary_Hair_Loss_The_End_of_The_Story [accessed Sep 10 2021].