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http://www.ncbi.nlm.nih.gov/pubmed/24989505
hair growth or regression without involving androgens? WTH?
Angela Christiano btw.:love:
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754481/
Mechanisms that regulate the growth of eyelashes have remained obscure. We ascertained two families from Pakistan who presented with familial trichomegaly, or extreme eyelash growth. Using a combination of whole exome sequencing and homozygosity mapping, we identified distinct pathogenic mutations within fibroblast growth factor 5 (FGF5) that underlie the disorder. Subsequent sequencing of this gene in several additional trichomegaly families identified an additional mutation in FGF5. We further demonstrated that hair fibers from forearms of these patients were significantly longer than hairs from control individuals, with an increased proportion in the growth phase, anagen. Using hair follicle organ cultures, we show that FGF5 induces regression of the human hair follicle. We have identified FGF5 as a crucial regulator of hair growth in humans for the first time, to our knowledge, and uncovered a therapeutic target to selectively regulate eyelash growth.
hair growth or regression without involving androgens? WTH?
Angela Christiano btw.:love:
- - - Updated - - -
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754481/
Although the gene for long hair in mammoths was not here identified, proboscideans remain an important group for understanding the evolution of hair cover. While most mammals have dense hair cover, humans and extant elephants are notable in being relatively hairless [28], and both are closely related to species with much greater hair cover (great apes and woolly mammoths, respectively). Both lineages are also noteworthy in being "genome-enabled" [40] for the study of genes affecting hair cover. The human and chimpanzee genomes have been sequenced [41], while the elephant genome is being sequenced [26], and substantial coverage for the mammoth genome is now available [15]. Other than aquatic species, the number of other mammalian genera considered to be "hairless" is quite small [28]. Thus, for a comparative approach to the evolution of hair cover, proboscideans comprise an important group for further research.
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