Fevipiprant Vs Setipiprant. Pgd2 Inhibitors.

[kiwipilu]

if anyone has a link/source to buy good uvb lamp *quality wise (shipping to europe) let me(us) know... always interesting.. even for skin a
ty.

 

[Maxxorr]

Fevipiprant is astronomically expensive(for now)

$938/1g

that's expensive.

 

[ALightInTheDark]

Possible alternatives to Seti/Fevi for decreasing CRTH2 activity :
https://pubchem.ncbi.nlm.nih.gov/compound/45268455#section=Chemical-Vendors
https://en.wikipedia.org/wiki/Indole-3-acetic_acid
https://www.sigmaaldrich.com/catalog/product/sigma/s3131?lang=fr&region=FR
http://pubs.acs.org/doi/abs/10.1021/ml200019y
https://www.sigmaaldrich.com/catalog/product/aldrich/a95502?lang=fr&region=FR
https://www.sigmaaldrich.com/catalog/product/aldrich/596825?lang=fr&region=FR

 

[Jk1]

I have found this : https://books.google.fr/books?id=kBV9oRSyZVoC&pg=PA105&lpg=PA105&dq=9a+11b-pgf2+inhibit&source=bl&ots=XKeDWdygiS&sig=o70yyn3TI7A0moeldZnwaoZeZ2A&hair loss=fr&sa=X&ved=0ahUKEwjJh9Cv7OPWAhUEa1AKHX5gCvQQ6AEIVTAH#v=onepage&q=9a 11b-pgf2 inhibit&f=false

It stated that "CRTH2 Activation : Decrease cAMP"

And guess what upregulates cAMP? https://www.ncbi.nlm.nih.gov/pubmed/6175546
"The increase in skin tyrosinase activity in response to UV was preceded by an increase in skin cAMP levels."
Also UVB is known to increase PGE2 by a lot.

interesting study does that me
an if we supplemebt with vit d their is more melanogenisis with the same uv exposure ? thats an interestinf feedback loop. so maybe not only direct uv is beneficial on scalp but internally helps as well ?