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Let me try to explain how this (wound healing) works with regards to hair growth and cancer.
In embryonic development a lot of pathways get turned on to generate certain cell types such as heart, neuronal, muscle, skeletal...ect. The Wnt's, BMP's, Notch, Hh's, FGF's, TGF, are a few of the major ones. Each of these pathways activate or repress certain gene targets and help cells to become a certain linage and then into a certain tissue. As I said before at different concentrations of each pathway or combinations of each generate different types of tissues. For example, Hh pathway can help to generate, muscle, skeletal, skin, and neuronal tissues. This is the basic concept of developmental biology.
After you are born (postnatal) most of these pathways are quiescent (not activated). Only in special circumstances do these pathways get activated in the adult. A special circumstance could be injury. When you injure yourself your body has to repair itself. A current model of how your body does is with adult stem cells that reside in various tissues. In the skin and hair follicle there is a place if I am not mistaken called the "bulge†This is one of the places that adult stem cells reside in the skin. So your body turns on a few of these pathways that where used during embryonic development to tell your adult stem cells to divide and turn into a certain linage such as skin or blood vessels. ect. This has been well documented in the literature.
This is why it is very probable that wound healing could cause hair growth near the wound.
Know try to understand this. What happens when these pathways get stuck on or in a continual state of repair? You could develop cancer based on how stuck these pathways really are. Think of the relationships, people who smoke have a high risk of lung cancer, and people who are in the sun are more likely to develop skin cancer. In both cases your lungs and skin have been repairing them years on end. What eventually could happen is that you will get a mutation in one of these pathways and it gets stuck ON. Also think of some phenotypes of cancer, they are poorly differentiated and undetected by the immune system. These are also hallmarks of adult stem cells.
As you can see these pathways hold great promise for hair growth but also yield great concern and caution.
In embryonic development a lot of pathways get turned on to generate certain cell types such as heart, neuronal, muscle, skeletal...ect. The Wnt's, BMP's, Notch, Hh's, FGF's, TGF, are a few of the major ones. Each of these pathways activate or repress certain gene targets and help cells to become a certain linage and then into a certain tissue. As I said before at different concentrations of each pathway or combinations of each generate different types of tissues. For example, Hh pathway can help to generate, muscle, skeletal, skin, and neuronal tissues. This is the basic concept of developmental biology.
After you are born (postnatal) most of these pathways are quiescent (not activated). Only in special circumstances do these pathways get activated in the adult. A special circumstance could be injury. When you injure yourself your body has to repair itself. A current model of how your body does is with adult stem cells that reside in various tissues. In the skin and hair follicle there is a place if I am not mistaken called the "bulge†This is one of the places that adult stem cells reside in the skin. So your body turns on a few of these pathways that where used during embryonic development to tell your adult stem cells to divide and turn into a certain linage such as skin or blood vessels. ect. This has been well documented in the literature.
This is why it is very probable that wound healing could cause hair growth near the wound.
Know try to understand this. What happens when these pathways get stuck on or in a continual state of repair? You could develop cancer based on how stuck these pathways really are. Think of the relationships, people who smoke have a high risk of lung cancer, and people who are in the sun are more likely to develop skin cancer. In both cases your lungs and skin have been repairing them years on end. What eventually could happen is that you will get a mutation in one of these pathways and it gets stuck ON. Also think of some phenotypes of cancer, they are poorly differentiated and undetected by the immune system. These are also hallmarks of adult stem cells.
As you can see these pathways hold great promise for hair growth but also yield great concern and caution.
