Everyone, who has their own theory on why and how we bald, please, post it here !!!

[Freakin_Speed]

I have seen many people having different theories about why exactly balding happens, and how, and the reasons involved in this proccess. So however strange your theory might be, please share it, i want to view all of your standpoints and opinions, and explain why do you think things happen so and so. I would be glad to read all of your explainings and theories and try to see what could be the most reasonable and logical for me and other users here can decide for themselves too ...
Thank you. ;D

 

[jbrog1987]

Here's a thread on my theory. Basically I feel PGD2 (and inflammation) may play a more causative role in hair miniaturization and hairloss and DHT may play a more peripheral/indirect role and may simply act as an initial trigger/fuel for the process once it begins.

http://www.hairlosstalk.com/interac...tential-Mechanism-Behind-Male-Pattern-Balding

 

[Freakin_Speed]

thank you for submitting it, i will start reading it in a minute ... ;D

 

[Vlatch]

Testosterone > DHT > inflammation > PGD2 > Hair loss.

Here's a thread on my theory. Basically I feel PGD2 (and inflammation) may play a more causative role in hair miniaturization and hairloss and DHT may play a more peripheral/indirect role and may simply act as an initial trigger/fuel for the process once it begins.

http://www.hairlosstalk.com/interac...tential-Mechanism-Behind-Male-Pattern-Balding

Yeah right, you've done some reading and it becomes "your theory".

 

[bluered999]

I really believe it used to be a beneficial trait in regards to health, because it would give your body more vitamin d production from the skin exposure.

 

[xRedStaRx]

Bald men are more likely to procreate. It's natural selection.

 

[Freakin_Speed]

come on, it seem that the people from this forum arent posting much, unless its about using the big 3, or success stories of regrowth, or they post only on threads of guys that are 18/19/20/21, asking if they are going bald ...

 

[jbrog1987]

Testosterone > DHT > inflammation > PGD2 > Hair loss.


Yeah right, you've done some reading and it becomes "your theory".

Um no. I didn't develop this theory wholesale from anything i've read. This is my take on the chain and my theory on the process.

 

[resu]

Some sort of weird mutation happened, it doesn't have any evolutionary purpose. Hair on the back doesn't have any purpose since it doesn't keep me warm in the winter and it grosses me out in the summer yet it's there.

Sunlight and vitamin d definitely had something to do with baldness, it's even linked with testosterone.

 

[Freakin_Speed]

^ Tell me more about the sunlight and vitamin D link with testosterone. ;D

 

[resu]

Vitamin D raises testosterone.

You're thinking about having low vitamin D levels so now you're balding, it doesn't matter anymore if your levels are high, low or normal, it was a gene mutation that happened who knows when in human history and like I said it didn't serve any purpose, it wasn't to get more vitamin d. Same as blue eyes mutation except that was a lot recently, blue eyes won't let more light in, evolutionary speaking it serves no functional purpose other than perhaps making a person more attractive but that's a social construct.

 

[shookwun]

I just look at the Crack head natives where I live who are bums on the street, engage in needle sharing, drug usage, and every carcinogenic activity in the book yet still have solid thick heads of hair. None of these theories matter when I look at these guys and realise it's all genetics and the luck of the draw. Their diets probably consist of Ramen noodles washed down with listerine.

Speculate all you Want.

Vitamin defeciency lol.... we live in a first world country for **** sake. None of that **** matters.

 

[xRedStaRx]

Vitamin D raises testosterone.

You're thinking about having low vitamin D levels so now you're balding, it doesn't matter anymore if your levels are high, low or normal, it was a gene mutation that happened who knows when in human history and like I said it didn't serve any purpose, it wasn't to get more vitamin d. Same as blue eyes mutation except that was a lot recently, blue eyes won't let more light in, evolutionary speaking it serves no functional purpose other than perhaps making a person more attractive but that's a social construct.

You don't understand how natural selection works.

Does it not make sense that bald men are more likely to rape? Did men wait until they got bald to have sex? It was never weeded out, because it got passed on, again and again.

 

[Swoop]

I can only point you to the consensus currently between many researchers and studies in Androgenetic Alopecia. In short it's like this;

Dermal papilla (DP) cells function as important regulators of the hair growth cycle. The loss of these cells is a primary cause of diseases characterized by hair loss, including alopecia, and evidence has revealed significantly increased levels of reactive oxygen species (ROS) in hair tissue and DP cells in the balding population.

This "stress" causes the DP cells to undergo DNA damage and in response to this major regulatory pathways set in and cause senescence/cell cycle arrest or apoptosis or a combination of both. I once made a picture of this to generally give a view of what happens, please do note that this doesn't obviously illustrate the exact chain of pathways that are implicated but should act as a "global view";

http://s29.postimg.org/crbgac7h3/Androgenetic Alopecia.jpg


Remember this is the view of many studies/researchers now currently. PGD2 is cute and stuff but most likely isn't the primary cause of Androgenetic Alopecia and holds a way less important role than upstream factors. Factually this would also explain why Androgenetic Alopecia is such a incredibly hard disease to reverse. Simply because these major regulatory pathways act as a sort super defensive mechanism of your cells. When enough damage is done they shut them self off or commit apoptosis. Hope that makes sense. There is much more to read though if anyone is interested.

DP amount (size) governs hair follicle size by the way and the DP acts as a instructive "master" niche of the hair follicle. A decline of DP cells leads to smaller hair follicle size.

It's pretty damn bad if they are right. Prevention is key atm.

 

[scottfs]

The Bcl-2/bax ratio is important, in my opinion. I believe this because when I started a cancer drug called ABT-199, my hair started to recede very, very fast. I was a Norwood 2 prior to ABT-199, and now I'm a 4. This is in 6 months.

ABT-199 is an important cancer drug because it helps cells die. Bcl-2 is a cell-death inhibitor, and bax is a cell death promoter. ABT-199 alters the ratio of Bcl-2/bax to tip it to help cells die. Some cancer cells just don't die like they are supposed to. This helps push them over the edge.

It turns out the hair-producing cells are governed by the same Bcl-2/bax ratio. ABT-199 is pushing those cells to die as well. I suspect that in male pattern baldness, there is a gradual alteration of the Bcl-2/bax ratio to promote hair cell death.

I give myself as a sad example of this process. It's a terrible side effect, but my oncologist is of the opinion that the drug is sort of working, and I'm not dead...yet...so continue the drug. I lose sleep over this. It's terrible to lose your hair so terribly fast.

 

[oye_rg]

I just look at the Crack head natives where I live who are bums on the street, engage in needle sharing, drug usage, and every carcinogenic activity in the book yet still have solid thick heads of hair. None of these theories matter when I look at these guys and realise it's all genetics and the luck of the draw. Their diets probably consist of Ramen noodles washed down with listerine.

Speculate all you Want.

Vitamin defeciency lol.... we live in a first world country for **** sake. None of that **** matters.

I second that. I've got completely messed up friends who look like zombies but still have full heads of hair.

 

[Yoshi3Mario]

We bald because it's in our DNA... Same reason why we grow ear hair, beards, *** hair, etc. It is what is. Either embrace it or take finasteride.

 

[Freakin_Speed]

I can only point you to the consensus currently between many researchers and studies in Androgenetic Alopecia. In short it's like this;



This "stress" causes the DP cells to undergo DNA damage and in response to this major regulatory pathways set in and cause senescence/cell cycle arrest or apoptosis or a combination of both. I once made a picture of this to generally give a view of what happens, please do note that this doesn't obviously illustrate the exact chain of pathways that are implicated but should act as a "global view";

http://s29.postimg.org/crbgac7h3/Androgenetic Alopecia.jpg


Remember this is the view of many studies/researchers now currently. PGD2 is cute and stuff but most likely isn't the primary cause of Androgenetic Alopecia and holds a way less important role than upstream factors. Factually this would also explain why Androgenetic Alopecia is such a incredibly hard disease to reverse. Simply because these major regulatory pathways act as a sort super defensive mechanism of your cells. When enough damage is done they shut them self off or commit apoptosis. Hope that makes sense. There is much more to read though if anyone is interested.

DP amount (size) governs hair follicle size by the way and the DP acts as a instructive "master" niche of the hair follicle. A decline of DP cells leads to smaller hair follicle size.

It's pretty damn bad if they are right. Prevention is key atm.

Thank you for submitting this. ;D Makes sense to me. ;D