- Reaction score
- 51
As already proven: ER α is bad for our hair and thus is ER β good.
Hair cycle control by estrogens: catagen induction via estrogen receptor (ER)-alpha is checked by ER beta signaling
Then I came across these two studies about muscle growth by ER β activation:
Selective estrogen receptor-β activation stimulates skeletal muscle growth and regeneration
Estrogen receptor beta is involved in skeletal muscle hypertrophy induced by the phytoecdysteroid ecdysterone
So in stead of using an ER β agonist as a topical, why not use it oral and grow some muscle as well?
Yes the only thing I can think is... This sounds too good to be true... So probably it is.
Surely there must be some kind of unwanted side effects when we raise our ER β systemically?
Anybody any idea?
I ordered some ecdysterone, so I'm gonna give this a shot purely for the possible muscle growth effect.
Ecdysterone is a bit controversial though. Some studies claim it works, at least one is saying it doesnt work. But that shouldnt matter too much in this discussion.
I wonder if every ER β agonist will have an effect on muscle growth. Because there are very selective ER β agonists around. Why not take them oral?
Curious to hear if somebody else has some more info / opinions on this topic.
Hair cycle control by estrogens: catagen induction via estrogen receptor (ER)-alpha is checked by ER beta signaling
Hair cycle control by estrogens: catagen induction via estrogen receptor (ER)-alpha is checked by ER beta signaling - PubMed
Although 17beta-estradiol (E2) is recognized as a potent hair growth modulator, our knowledge of estrogen function, signaling, and target genes in hair biology is still very limited. Between the two recognized estrogen receptors (ERs), ER alpha and ER beta, only ER alpha had been detected in...
pubmed.ncbi.nlm.nih.gov
Then I came across these two studies about muscle growth by ER β activation:
Selective estrogen receptor-β activation stimulates skeletal muscle growth and regeneration
Selective estrogen receptor-β activation stimulates skeletal muscle growth and regeneration - PubMed
There is increasing evidence suggesting that estrogens augment skeletal muscle regeneration processes after injury. To study the contribution of estrogen receptors α and β (ERα and ERβ) during muscle regeneration, skeletal muscles of ovariectomized (OVX) rats, as well as ERα- and ERβ-knockout...
pubmed.ncbi.nlm.nih.gov
Estrogen receptor beta is involved in skeletal muscle hypertrophy induced by the phytoecdysteroid ecdysterone - PubMed
These findings provide new therapeutic perspectives for the treatment of muscle injuries, sarcopenia, and cachectic disease, but also imply that such a substance could be abused for doping purposes.
pubmed.ncbi.nlm.nih.gov
So in stead of using an ER β agonist as a topical, why not use it oral and grow some muscle as well?
Yes the only thing I can think is... This sounds too good to be true... So probably it is.
Surely there must be some kind of unwanted side effects when we raise our ER β systemically?
Anybody any idea?
I ordered some ecdysterone, so I'm gonna give this a shot purely for the possible muscle growth effect.
Ecdysterone is a bit controversial though. Some studies claim it works, at least one is saying it doesnt work. But that shouldnt matter too much in this discussion.
I wonder if every ER β agonist will have an effect on muscle growth. Because there are very selective ER β agonists around. Why not take them oral?
Curious to hear if somebody else has some more info / opinions on this topic.