waynakyo
Experienced Member
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[FONT=Verdana, Arial, Tahoma, Calibri, Geneva, sans-serif]Exp Dermatol. 2014 Jul 9. doi: 10.1111/exd.12488. [Epub ahead of print][/FONT]
[h=1][FONT=Verdana, Arial, Tahoma, Calibri, Geneva, sans-serif]Epigenetic control of skin and hair regeneration after wounding.[/FONT][/h][FONT=Verdana, Arial, Tahoma, Calibri, Geneva, sans-serif]Plikus MV1, Guerrero-Juarez CF, Treffeisen E, Gay DL.[/FONT]
[h=3][FONT=Verdana, Arial, Tahoma, Calibri, Geneva, sans-serif]Author information[/FONT][/h]
[h=3][FONT=Verdana, Arial, Tahoma, Calibri, Geneva, sans-serif]Abstract[/FONT][/h][FONT=Verdana, Arial, Tahoma, Calibri, Geneva, sans-serif]Skin wound healing is a complex regenerative phenomenon that can result in hair follicle neogenesis. Skin regenerationrequires significant contribution from the immune system and involves substantial remodeling of both epidermal and dermal compartments. In this viewpoint, we consider epigenetic regulation of reepithelialization, dermal restructuring and hair neogenesis. Because little is known about the epigenetic control of these events, we have drawn upon recent epigenetic mapping and functional studies of homeostatic skin maintenance, epithelial-mesenchymal transition in cancer, and new works on regenerative dermal cell lineages and the epigenetic events that may shape their conversion into myofibroblasts. Finally, we speculate on how these various healing components might converge for wound-induced hair follicle neogenesis. This article is protected by copyright. All rights reserved.[/FONT]
[FONT=Verdana, Arial, Tahoma, Calibri, Geneva, sans-serif]This article is protected by copyright. All rights reserved.[/FONT]
[h=1][FONT=Verdana, Arial, Tahoma, Calibri, Geneva, sans-serif]Epigenetic control of skin and hair regeneration after wounding.[/FONT][/h][FONT=Verdana, Arial, Tahoma, Calibri, Geneva, sans-serif]Plikus MV1, Guerrero-Juarez CF, Treffeisen E, Gay DL.[/FONT]
[h=3][FONT=Verdana, Arial, Tahoma, Calibri, Geneva, sans-serif]Author information[/FONT][/h]
[h=3][FONT=Verdana, Arial, Tahoma, Calibri, Geneva, sans-serif]Abstract[/FONT][/h][FONT=Verdana, Arial, Tahoma, Calibri, Geneva, sans-serif]Skin wound healing is a complex regenerative phenomenon that can result in hair follicle neogenesis. Skin regenerationrequires significant contribution from the immune system and involves substantial remodeling of both epidermal and dermal compartments. In this viewpoint, we consider epigenetic regulation of reepithelialization, dermal restructuring and hair neogenesis. Because little is known about the epigenetic control of these events, we have drawn upon recent epigenetic mapping and functional studies of homeostatic skin maintenance, epithelial-mesenchymal transition in cancer, and new works on regenerative dermal cell lineages and the epigenetic events that may shape their conversion into myofibroblasts. Finally, we speculate on how these various healing components might converge for wound-induced hair follicle neogenesis. This article is protected by copyright. All rights reserved.[/FONT]
[FONT=Verdana, Arial, Tahoma, Calibri, Geneva, sans-serif]This article is protected by copyright. All rights reserved.[/FONT]