- Reaction score
- 1,132
There are other studies where they put follicles from top of the scalp in a EX-VIVO environement, they are stable and keep growing
They just throw DHT in there, follicles dies, you can find them too.
An Histopathologic view of scalp skin is very easy to do, and has been studied over and over and over, if the problem was the scalp skin, they'll knew it for decades now
And we unfortunately saw the recent results of JAKs, supposed to disrupt those supposedly immune mecanisms of skin inflammation and so on...
That's a dead end for Androgenetic Alopecia, there's plenty of others synergic causes
"...sustained microscopic follicular inflammation with connective tissue remodeling, eventually resulting in permanent hair loss, is considered a possible cofactor in the complex etiology of Androgenetic Alopecia."
"connective tissue remodeling" indeed....cofactor ? Surely
But where it all starts ? Hair follicle bulge for sure
Multi factorials diseases need multi factorial treatments, but that's my humble opinion
Edit : My Bad
Effects of inflammation on stem cells: together they strive?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388609/
"Finally, a clear negative effect of inflammation is seen in hair follicle stem cells. Inflammation has been shown to negatively regulate epidermal stem cell activity in keratin-15/CD34-positive hair follicle cells 106. In a mouse model of permanent hair loss, immunoprivileged hair follicle sac shows elevated levels of inflammation with increased TNF-α and MCP-1 upon macrophage and dendritic cell invasion, whereas immunosuppression rescues the normal physiology of the stem cells 107. Several chronic inflammatory states compromise the function of the hair stem cell niche through modulation of interferon-inducible cytokine expression 108, suggesting that inflammation negatively affects epidermal stem cell activity."
To verify with cross sources
They just throw DHT in there, follicles dies, you can find them too.
An Histopathologic view of scalp skin is very easy to do, and has been studied over and over and over, if the problem was the scalp skin, they'll knew it for decades now
And we unfortunately saw the recent results of JAKs, supposed to disrupt those supposedly immune mecanisms of skin inflammation and so on...
That's a dead end for Androgenetic Alopecia, there's plenty of others synergic causes
"...sustained microscopic follicular inflammation with connective tissue remodeling, eventually resulting in permanent hair loss, is considered a possible cofactor in the complex etiology of Androgenetic Alopecia."
"connective tissue remodeling" indeed....cofactor ? Surely
But where it all starts ? Hair follicle bulge for sure
Multi factorials diseases need multi factorial treatments, but that's my humble opinion
Edit : My Bad
Effects of inflammation on stem cells: together they strive?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388609/
"Finally, a clear negative effect of inflammation is seen in hair follicle stem cells. Inflammation has been shown to negatively regulate epidermal stem cell activity in keratin-15/CD34-positive hair follicle cells 106. In a mouse model of permanent hair loss, immunoprivileged hair follicle sac shows elevated levels of inflammation with increased TNF-α and MCP-1 upon macrophage and dendritic cell invasion, whereas immunosuppression rescues the normal physiology of the stem cells 107. Several chronic inflammatory states compromise the function of the hair stem cell niche through modulation of interferon-inducible cytokine expression 108, suggesting that inflammation negatively affects epidermal stem cell activity."
To verify with cross sources
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