EGCG

[Red Rose]

I haven't heard anyone talk about green tea for ages.

Hasn't topical EGCG been proven in vivo to inhibit 5a-reductase in sebaceous glands even more so than topical fatty acids?

Are there any topical EGCG products that anyone knows of?

 

[Red Rose]

This is from the study: "Selective Inhibition of Steroid 5alpha-Reductase Isozymes by Tea Epicatechin-3-Gallate and Epigallocatechin-3-Gallate", Liao and Hiipakka, Biophys Biochem Res Commun 214:833-838, 1995.

They say near the end of the study: "...We have found that EGCG also reduced 5alpha-DHT production from testosterone by cells in culture. In line with these observations, we have found that EGCG administered to male rats could reduce the weight of male accessory organs, such as ventral prostate, seminal vesicle, and coagulating gland without affecting the weight of testis or kidney. We have also found that topical application of EGCG or gamma-linolenic acid can inhibit sebum production by the male human forehead (unpublished observation)."

 

[jimmystanley]

damn hippies...i thought we got rid of them all

 

[Bryan]

Hasn't topical EGCG been proven in vivo to inhibit 5a-reductase in sebaceous glands even more so than topical fatty acids?

It was effective in that human test you cited in another thread, and also in another hamster test (citation available on request), but not as effective as GLA. At least, not at the doses that were used in those tests.

Bryan