Effectiveness Of Topical Antiandrogens

[diffuse_thinner]

I'm looking for feedback on the best topical Antiandrogens. I live in Australia and topical Finasteride seems impossible to source. Is spironolactone a good option?
Thanks

 

[whatevr]

Cyproterone acetate
Progesterone
RU58841
CB 03 01
Alfatradiol

 

[Mac12345]

The main problem is getting hold of these products. Any idea where to buy RU? I've looked and had no luck.

 

[buckthorn]

The main problem is getting hold of these products. Any idea where to buy RU? I've looked and had no luck.

http://www.thekaneshop.com/

 

[whatevr]

http://www.thekaneshop.com/

Expensive AF.

 

[buckthorn]

Expensive AF.

I don't see how you think that is so expensive, especially in comparison to other hair loss treatments??

I mean, you can get 10g for $130. at 5% concentration, you are using 500mg/10ml. 10ml will last you ten days. 10,000mg (10g) will then last you 100 days. round down to 90 days (3months) for spillage and extra usage. $130 for 3 months isn't bad, imo. especially if it works for you.

 

[whatevr]

I don't see how you think that is so expensive, especially in comparison to other hair loss treatments??

I mean, you can get 10g for $130. at 5% concentration, you are using 500mg/10ml. 10ml will last you ten days. 10,000mg (10g) will then last you 100 days. round down to 90 days (3months) for spillage and extra usage. $130 for 3 months isn't bad, imo. especially if it works for you.

What I'm saying is it can be gotten cheaper. Kane is a reseller, he doesn't really make his own stuff anyway.

 

[buckthorn]

What I'm saying is it can be gotten cheaper. Kane is a reseller, he doesn't really make his own stuff anyway.

I didn't know that... seriously? I thought he made all his own compounds.

It can probably be gotten cheaper, but would you totally trust it?

 

[whatevr]

I didn't know that... seriously? I thought he made all his own compounds.

It can probably be gotten cheaper, but would you totally trust it?

By what account can you trust Kane? If you can test it, you can trust it. When buying online like this you're very rarely dealing with the actual lab producing the stuff, usually it's a 3rd or even 4th party stepping in between you and the actual source and raking in on the mark-up.

There is a far more affordable source that has been 3rd party tested and found to be legit. I'm about to order from there myself in about a week, and then I will make a log with RU and some other topicals. If everything turns out fine (i.e. the stuff makes it through customs and proves to be the real deal) then I'll write about the whole thing including where I got it from.

 

[buckthorn]

By what account can you trust Kane? If you can test it, you can trust it. When buying online like this you're very rarely dealing with the actual lab producing the stuff, usually it's a 3rd or even 4th party stepping in between you and the actual source and raking in on the mark-up.

There is a far more affordable source that has been 3rd party tested and found to be legit. I'm about to order from there myself in about a week, and then I will make a log with RU and some other topicals. If everything turns out fine (i.e. the stuff makes it through customs and proves to be the real deal) then I'll write about the whole thing including where I got it from.

Well, that's good then! The more reputable sources, the better. I was just saying I think Kane himself produces his chemicals. Most of which have been tested numerous times by people on this forum and others. It always came back like 99% pure.

It's also just simple economics imo. Kane has a reputation and he is one of the few people that is known for his compounds. Why in God's name would he be stupid enough to water down, or improperly formulate a relatively simple compound to produce? One that's making him tons of money and one that he knows people like us will test on international forums like this one?

 

[whatevr]

Well, that's good then! The more reputable sources, the better. I was just saying I think Kane himself produces his chemicals. Most of which have been tested numerous times by people on this forum and others. It always came back like 99% pure.

It's also just simple economics imo. Kane has a reputation and he is one of the few people that is known for his compounds. Why in God's name would he be stupid enough to water down, or improperly formulate a relatively simple compound to produce? One that's making him tons of money and one that he knows people like us will test on international forums like this one?

Obviously I didn't trace down his production site and personally verify that it's actually his (or not), I'm just saying that it's usually the middle men who set up websites and reach out to the buyers whereas the labs may merely advertise on buying platforms waiting for the buyers to come to them.

His compounds are legit and they may be all well and good, but the price is definitely too high. Kane is just coasting on his long term reputation in the hair loss circles as the "only" legit supplier of RU and other chemicals to keep the price high. Once more and more people start buying elsewhere he will come around.

 

[jb5]

I don't see how you think that is so expensive, especially in comparison to other hair loss treatments??

I mean, you can get 10g for $130. at 5% concentration, you are using 500mg/10ml. 10ml will last you ten days. 10,000mg (10g) will then last you 100 days. round down to 90 days (3months) for spillage and extra usage. $130 for 3 months isn't bad, imo. especially if it works for you.

10,000mg at 50mg per day would actually last you 200 days.

 

[kj6723]

Do we have any accounts of anyone on here getting regrowth exclusively from a topical anti-androgen?

i.e. no minoxidil or other treatment being used simultaneously, so we know the anti-androgen itself was what was having the effect?

 

[whatevr]

Do we have any accounts of anyone on here getting regrowth exclusively from a topical anti-androgen?

i.e. no minoxidil or other treatment being used simultaneously, so we know the anti-androgen itself was what was having the effect?

Probably about the same or lesser likelihood of getting regrowth using just finasteride.
Removing DHT merely prevents further damage. It doesn't repair what's already done - that's what estrogen is for.

 

[julien1200]

HI Whatever,

Is topical CA better than topical RU ?

Best

 

[Swoop]

HI Whatever,

Is topical CA better than topical RU ?
Best

In terms of binding to the AR, RU is probably stronger;

"When compared with the antiandrogenic compound cyproterone acetate, PSK-3841 exhibited a 20% increase in androgen receptor binding."

But that's the only thing RU does really from what we know. CA does more and also can slash down your testosterone with like 80-90% when it goes systemic. Not sure how much it would go systemic when used as a topical though. But CA orally is certainly stronger than RU.

 

[InBeforeTheCure]

In terms of binding to the AR, RU is probably stronger;

"When compared with the antiandrogenic compound cyproterone acetate, PSK-3841 exhibited a 20% increase in androgen receptor binding."

But that's the only thing RU does really from what we know. CA does more and also can slash down your testosterone with like 80-90% when it goes systemic. Not sure how much it would go systemic when used as a topical though. But CA orally is certainly stronger than RU.

Since CPA is a steroid, and therefore very hydrophobic, we should expect it to be easily absorbed systemically, shouldn't we?

EDIT: Found a study where they used topical CPA in a liposome lotion successfully for acne with lower systemic absorption:

Previous studies using topical cyproterone acetate have been unsuccessful because of inability to deliver the active substance to the target cell. This disadvantage was overcome by using a liposome lotion as the carrier for the active drug. Serum cyproterone acetate levels were 10 times lower after topical application than after oral use, but with a similar clinical response.

http://www.aafp.org/afp/1998/1015/p1442.html

 

[scarlet411]

Does anyone know how to make topical cypretone acetate ? Mine seems very 'bitty' after dissolving in alcohol for 3 days. Can I assume that the actual drug part is dissolved ?

 

[growssj3]

Estradiol, can so explain? Which product has it in, and shouldnt give sides 100%

 

[hairblues]

I'm using topical blend of spironolactone, estrodial-17 alpha, caffein and melatonin for about 10-12 weeks aprox and i am using 5% minoxidil 1x a day for about 6 weeks..

I am having a lot less shedding...especially the hairs that have been short cycling for years--those are finally staying in my head and starting to grow.
I also see new growth where i had small spots of no hair..i cannot tell yet how dense of long it will get but just happy to see activity.

Im also on a high dose of iron for low ferritin...

I cannot say for sure what is doing what.

Oral spironolactone gave me sides regarding my period, the topical i have no side effects.
Hard to know if its doing anything or if its the minoxidil.