squeegee
Banned
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oxygen is essential for life in humans and other mammals. Insufficient oxygen, hypoxia, in tissues or cells results in physiological and pathological responses such as ischemia, stroke, hemorrhage (6, 33, 39), and many cardiopulmonary injuries (6, 41). Cellular hypoxia causes an induction of hypoxia-response genes related to the angiogenesis, oxygen transport, and metabolism (1). It has been shown that hypoxia can increase the concentration of intracellular free calcium, nitric oxide (20), and inducible nitric oxide synthase (iNOS; see Refs. 28 and 38) and generation of polymorphonuclear neutrophils (38) and leukotriene B[SUB]4[/SUB] (27).
Recent studies demonstrated that treatment with iNOS inhibitor can reduce lipid peroxidation, apoptosome formation, and intracellular caspase-3 activity, maintain the ATP levels, and promote cell survival (27). Other studies have shown that intermittent hypoxia treatment for 14 days can protect the rats from oxidative injury because of by the presence of more bilirubin (5).
http://0-ajpendo.physiology.org.library.pcc.edu/content/292/6/E1763.full
Recent studies demonstrated that treatment with iNOS inhibitor can reduce lipid peroxidation, apoptosome formation, and intracellular caspase-3 activity, maintain the ATP levels, and promote cell survival (27). Other studies have shown that intermittent hypoxia treatment for 14 days can protect the rats from oxidative injury because of by the presence of more bilirubin (5).
http://0-ajpendo.physiology.org.library.pcc.edu/content/292/6/E1763.full