ECGC: massive reduction in HUMAN sebum secretion, study

[michael barry]

Topical green tea................massive reduction in sebum: Study (Topicals)
posted by benji, 27.03.2008, 02:00


2. Catechin Inhibition of Human Forehead Sebum Production

Twenty mg of (-)epigallocatechin gallate (EGCG) in 0.2 ml 70% ethanol was applied to the left forehead twice a day for 6 days (FIG. 25). The L/R ratio decrease from 1.20±0.02 to 0.71±0.04 during this period. After the EGCG treatment was stopped, the L/R ratio gradually recovered to 1.19±0.02 within 16 days. Subsequent treatment of the left forehead with 20 mg (-)epicatechin in 0.2 ml 70% ethanol twice a day for 6 days reduced the L/R ratio to 1.02±0.1. After the application was stopped, the L/R ratio gradually increased to the normal value of 1.21±0.01 in 10 days. Clearly EGCG was more effective in reducing the sebum production from forehead than (-)epicatechin.



http://www.freepatentsonline.com/5605929.html


You will have to go down to near the bottom of the patent to see that.......................and its a big, long, patent




ECGC, in green tea, also caused a large reduction in the growth of hamster flank organs, but this showed it can be anti-androgenic in human skin----at least at the sebaceous gland level.

 

[billythekid]

that's great news... i think.

i'm not sure about the reduction in growth of hamster flank organs, what does that mean?

as soon as my order comes in, I will be applying topical GTE disolved in emu oil every second day.

 

[billythekid]

ok i get it now. it's a good thing.

Growth suppression of hamster flank organs by topical application of catechins, alizarin, curcumin, and myristoleic acid.
Hamster flank organ growth, as measured by an increase in the area of the pigmented macule, is androgen-dependent. When flank organs of a castrated hamster are treated topically with testosterone, the flank organ becomes larger and darker. Since this growth is known to be dependent on the intracellular active androgen, 5alpha-dihydrotestosterone (DHT), inhibitors of 5alpha-reductase which converts testosterone to DHT can inhibit the growth of the flank organ. Certain unsaturated aliphatic fatty acids, such as gamma-linolenic acid and myristoleic acid, as well as other natural compounds, including alizarin and curcumin, are 5alpha-reductase inhibitors and inhibited flank organ growth. Green tea catechins, including (-)-epicatechin-3-gallate, and (-)-epigallo-catechin-3-gallate (EGCG) are also 5alpha-reductase inhibitors and inhibited flank organ growth. However, (-)-epicatechin and (-)-epigallocatechin, which are not 5alpha-reductase inhibitors, also inhibited flank organ growth. EGCG also inhibited DHT-dependent growth of flank organs. These catechins, therefore, may act by a mechanism other than inhibition of 5alpha-reductase. The effect of EGCG and other compounds was localized at the site of application; they did not affect the growth of the contralateral flank organ in the same animal. Since these compounds do not appear to exhibit systemic effects, they may be potentially useful for treatment of androgen-dependent skin disorders.

PMID: 11380153 [PubMed - indexed for MEDLINE]