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So in theory keeping pgd2 under control should stop further hair loss?Linkage between dermal adipose tissue status, WNTb catenin, PGD2 prostaglandins, Androgenic receptors.
"As different prostaglandins have opposing biological effects, PGD2 MAY MEDIATE testosterone INHIBITION OF WNT signaling IN Androgenetic Alopecia. Future studies are needed to test this hypothesis. ! It is interesting to speculate that AR roles in other physiological processes may be tied to its role as a β-catenin/Wnt inhibitor."
"We conclude that activation of Wnt/β-catenin signaling in adult epidermis STIMULATES ADIPOGENESIS in association WITH INDUCTION OF anagen and ectopic HF FORMATION."
"They also show that overexpression of localized WNT CONVERTS dermal ADIPOSE CELLS INTO a distinct FIBROBLAST subtype, which leads to fibrosis and disrupted hair follicle cycling."
"The authors of several articles (Hamburg and Atit, 2012, Mastrogiannaki et al., 2016, Wei et al., 2011), speculate that inhibition of Wnt signaling could be a new therapeutic target for the treatment of skin fibrotic diseases."
Has anyone investigated or even tried any WNTb modulating drugs? GSK3B inhibitors? DKK1 inhibitors? SM04554?