Mestys said:Dutasteride is more effective because it has a stronger affinity to the 5AR Type 1 enzyme which reduces levels of DHT even more than Finasteride.
Haircut said:What the hell..
I did some mini-research on the stuff and when used with proscar it inhibited up to 89% DHT.. and was found to be effective in combating male pattern baldness
Haircut said:Why was MK-386 never pursued?
el longhorn said:Dutasteride inhibits types 1 and 2 of the 5AR enzyme resulting in up to 90% of DHT suppression. Finasteride targets only the type 2 class of the enzyme and gives approximately 70% DHT suppression. (correct me if I'm wrong this is all info from lecture this semester on BPH)
Affinity of dutasteride is much greater for 5AR hence the dosage difference of only 0.5mg Avodart vs. 5mg Proscar... It blows my mind that some people claim less sides using dutasteride over finasteride?
el longhorn said:Dutasteride inhibits types 1 and 2 of the 5AR enzyme resulting in up to 90% of DHT suppression. Finasteride targets only the type 2 class of the enzyme and gives approximately 70% DHT suppression. (correct me if I'm wrong this is all info from lecture this semester on BPH)
pv78 said:Mr Bryan,
about dutasteride I've a question:did you read the Glaxo trial about comparison between finasteride 5 mg and different dutasteride dosages?
pv78 said:Well,in six months dutasteride 2 mg make an improvement about 2 times better than finasteride 5 mg,and about 1.5 times better than dutasteride 0.5 mg.But,I suppose,the amount of 5 alpha reductase type II blocked was similar,99%.So,why this big difference if the inhibition of type II is the same?
Just try it you'll find outSorry to bump an old thread, but does anyone know about the difference in side effect potential between finasteride and dutasteride?
Dutasteride has a moderately greater risk of side-effects than Finasteride, due to the fact that it inhibits significantly more DHT production.