BaldingHelpMe
Established Member
- Reaction score
- 21
They are both 5AR competitive inhibitors, and part of their structures look identical. But why is Finasteride has a half-life of only 8 hours and has a flat response curve; while Dutasteride has a half-life of 5 weeks, and it's said to be dose-dependent?
Anyone has a background in chemistry and bioscience wanna explain these two structures, what makes them different? Part of dutasteride's structure contains the entire structure of finasteride, so it looks like dutasteride is "finasteride plus something extra".
Dutasteride:
https://en.wikipedia.org/wiki/Dutasteride#/media/File:Dutasteride.svg
https://pubchem.ncbi.nlm.nih.gov/compound/finasteride#section=Top
Finasteride
https://en.wikipedia.org/wiki/Finasteride#/media/File:Finasteride.svg
https://pubchem.ncbi.nlm.nih.gov/compound/Dutasteride#section=Top
Anyone has a background in chemistry and bioscience wanna explain these two structures, what makes them different? Part of dutasteride's structure contains the entire structure of finasteride, so it looks like dutasteride is "finasteride plus something extra".
Dutasteride:
https://en.wikipedia.org/wiki/Dutasteride#/media/File:Dutasteride.svg
https://pubchem.ncbi.nlm.nih.gov/compound/finasteride#section=Top
Finasteride
https://en.wikipedia.org/wiki/Finasteride#/media/File:Finasteride.svg
https://pubchem.ncbi.nlm.nih.gov/compound/Dutasteride#section=Top
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