Yes, around 1 in 10 people find the PPG in regular minoxidil (Kirkland, Rogaine, Regaine etc) causes scalp irrititaion.
Is is very rarely the actual minoxidil that causes irritation.
Standard minoxidil contains 30% alcohol and 50% PPG
Dr Lees minoxidil contains 50% alcohol and 30% PPG
This may not seem like a great reduction, but it makes a real difference, it also only take 10 minutes or so to dry unlike the greasier Rogaine which is never really completely dry.
Dr Lee also does a PPG free minoxidil, but this is even greasier and slower drying than Rogaine.