maximiliandreams said:Yea,it's kinda travelling with airplane with months,preparing for battle....it has reserved a place in a 5 stars hotel ..then in the hotel there would be a naked hair follicle wh***... wainting for him to make action ..dude come one,dumb questions..OFCOURSE !
Rocky V said:maximiliandreams said:Yea,it's kinda travelling with airplane with months,preparing for battle....it has reserved a place in a 5 stars hotel ..then in the hotel there would be a naked hair follicle wh***... wainting for him to make action ..dude come one,dumb questions..OFCOURSE !
stop being an *** bro. this is what the forums are for to educate people who don't know anything about hair loss.
all it takes is a smart *** comment like yours to discourage people and make them not want to ask questions ever again.
relax
hairhoper said:Topical spironolactone is unlikely to make the slightest bit of difference.
Well, I finally obtained what is apparently the only published study using topical spironolactone for male pattern baldness in the whole world. Unfortunately, it's a little disappointing because it's far from a carefully controlled study. But it's all we have: "Topical Spironolactone in the Treatment of Androgenetic Alopecia", R. Bianchini, G. Buzzetti, L. Colombo, Rivista Italiana di Biologia e Medicina, Vol. 6(2) (pp 129-131), 1986.
52 patients completed a year-long study in which they were treated twice daily with a 3% topical spironolactone solution in a vehicle of ethanol, water, and glycerin. They say: "We evaluated hair density at the site treated, according to a conventional rating scale (0 = hair almost absent; 1 = hair very scanty; 2 = hair rather thin; 3 = hair moderately thin), on the basis of clinical assessment and standardized photography. These observations were carried out before, and after 6 and 12 months of treatment. The data obtained were analyzed by the Friedman and Wilcoxon tests".
From a starting score of exactly 1.00, after 6 months it was 1.212 (they claim a probability p<0.01 for this result) and after 12 months it was 1.75 (p< 0.001). That's about it. No hair-counts, trichograms, or hair-shaft diameters; just a somewhat subjective rating of these 52 subjects. However, they do provide before-and-after photographs of a couple of them, and there *is* some interesting hair-growth that you can plainly see; it's similar to those Propecia pictures of good responders that we've all seen on Web sites.
Here are the last few comments in the study: "With S therapy, several of our patients noted regrowth of hair and its long-term administration did not produce side effects or any decrease in blood pressure. To our knowledge, use of topical S in the treatment of AA has never been reported before. In conclusion, we believe that S acts directly as an antagonist of dihydrotestosterone on target tissue. Furthermore, the present study shows the possibility of using a testosterone inhibitory drug without systemic antiandrogenic side effects".
hairhoper said:You have to admit that a single (dated) study, small study group, a solely subjective opinion and no statistical data is not much to go on though, right?
hairhoper said:I reserve the right to be blunt about treatments til they've otherwise proven themselves to be worthy of our attention.
No hair-counts, trichograms, or hair-shaft diameters; just a somewhat subjective rating of these 52 subjects
hairhoper said:Again, please post them if so. If there are other studies, why did you only refer to this weak Italian one?
hairhoper said:Statistical evidence yet no actual measurements? In what form could that be? In your own words:
No hair-counts, trichograms, or hair-shaft diameters; just a somewhat subjective rating of these 52 subjects
Materials and methods
[...]
We evaluated hair density at the site treated, according to a conventional rating scale (0 = hair almost absent; 1 = hair very scanty; 2 = hair rather thin; 3 = hair moderately thin), on the basis of clinical assessment and standardized photography. These obversations were carried out before, and after 6 and 12 months of treatment.
The data obtained were analysed by the Friedman and Wilcoxon tests.
hairhoper said:Fact is no-one appears to have used topical spironolactone to any success that I'm aware of.
Advising people that they should use it seems like awful advice to me. I'm far more concerned about people getting ripped-off than the chance I may inadvertently bad-mouth a few old studies.