Does spironolactone get abosrbed systematically? Any evidence please?

[ANDREW_J_I]

Hi guys,

I am really wondering whether this happens or not. Do any of you have a links to studies from using spironolactone topically??? Does it get absorbed systematically even through this way?


Cheers

 

[philly]

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[ANDREW_J_I]

sh*t, i been applying it all over my head in very large amounts once a day....

What other topical alternatives are there though??

 

[ghg]

s***, i been applying it all over my head in very large amounts once a day....

What other topical alternatives are there though??

Not a lot... consider something with copper peptides maybe? There's also a thing called super zix that some folks swear by.

 

[philly]

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[ghg]

Revivogen.

Yeah that too, I'd love to try it but it's too expensive for me.

 

[philly]

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[ANDREW_J_I]

how many places can you buy revivogen from guys? Thank u.

 

[philly]

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[ANDREW_J_I]

anywhere else?

 

[ghg]

$165 for 6 months isn't that much. Some guys here have regimens costing way over $400 per month.

Yeah but the problem for me as a student is that I'll never get that much spare money to splash on a hairloss treatment. Not until I graduate and get a job. 400$ a month is just overkill and tells about massive insecurity.

 

[ANDREW_J_I]

also, what is delivery like please. Dr Lees delivery is amazing

 

[pproctor]

There are two main papers relevant to systemic aborbtion of spironolactone. Don't have time to look them up (will try to do this later). Basically, they are as follows:

1) Hamsters have paired "flank organs" on each side that are androgen sensitive. Application of topical spironolactone to one side causes antiandrogenic effects on that flank organ, but not on the other. Ergo, the effect is not due to systemic absorbtion.

2) Following topical application of spironolactone to human skin, the drug cannot be detected in blood. This is thought to be partially secondary to metabolism to inactive metabolites as the agent transverses the skin.

Peter H. Proctor, PhD,MD

 

[philly]

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[ANDREW_J_I]

hmmm, is it as dangerous as propecia or even close to???? that is the question. people use spironolactone as an alternative!

 

[philly]

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[caper0101]

Topical spironolactone 5% definitely gets absorbed systematically, at least in my opinion. I had problems with finasteride, stopped, and didn't take any DHT inhibitors for 6 months until the sides had finally more-less subsided. Then I started on spironolactone. I def still got some sides, but not NEARLY as bad. With finasteride I had NO sex drive, and my junk didn't work properly at all! The turning point was when I had the hottest girl I'd ever had in my bed naked and I couldn't get it going. :>( Threw away the bottle that night! On spironolactone my sex drive is a little lower, I can actually get work done during the day without day dreaming about my cube mate, but I see it as an acceptable compromise, and my junk more-less works normally. Maybe a little softer, but again acceptable compromise.

I also notice, if I stop spironolactone for 2-3 days my sex drive goes insane for a few days, totally through the roof. Then, after a week or so it settles to something between that and what it is now. I have repeated this experiment 2 or 3 times to be sure it wasn't a freak thing. Every time, same result!

 

[caper0101]

There are studies showing that topical finasteride doesn't get into the blood.

There are studies showing that topical finasteride does indeed get into the blood.

The results are all over the map. One study showing that topical spironolactone doesn't get into the blood is absolutely not enough. You need many more, especially considering the dangerousness of the drug.

Haha, try it for a week, you'll know pretty quick whether it's getting absorbed into the blood or not. Its not rocket science.

 

[pproctor]

What are your side-effects? A principle in therpeutics says that if a drug doesn't cause a side-effect when given systemically, it is not going to cause the side-effect when used topically. Used systemically for (say) a diuretic in heart failure, the side-effects of spironolactone are 1) You have to pee a lot and 2) antiandrogenic. Plus potassium retention if used chronically. This is at typical daily doses up to (say) 200 mg per day. This is far in excess of what you would put on your skin.

Dr Proctor