Does Nizoral gradually lose it's efficacy in helping male pattern baldness?

[jayC99]

As propecia and rogaine seem to?

I'm thinking that people should always start out on 1% since the benefits are nearly identical to 2%. Then, as the 1% begins to lose effectiveness you can change over to the more potent 2%...


Good idea?

 

[Radio]

Neither Propecia nor Rogaine lose efficacy with time.

Nizoral (ketoconazole) does not lose its efficacy with time.

 

[HairlossTalk]

Rogaine results did dissipate after roughly 4-5 years.

Propecia results dissipated slightly after 7 years. Very slightly.

We have no data on Nizoral to point to, to answer this question.

Either way I completely agree with your assessment. Its generally always a good rule to start small and work your way up. This way you can pace yourself for several years of fighting hair loss, without dumping everything on at once, and running out of options in a shorter time.

HairLossTalk.com

 

[Radio]

Rogaine results did dissipate after roughly 4-5 years.

Propecia results dissipated slightly after 7 years. Very slightly.

I believe both these studies were conducted in isolation, from this I gather that the Rogaine trials showed that after 4-5 years the male pattern baldness process 'takes over' from minoxidils anagen extending effects, I would not nessecerally read that as a loss of efficacy.

Propecia does not inhibit 100% of DHT, indeed we would not want it to, it would not be unreasonable to assume that your hair would begin to suffer after 7 years of even reduced DHT exposure. Again, I would not read this as a loss of efficacy.

We have no data on Nizoral to point to, to answer this question.

This is true, my best guess would be not to guess and presume that ketoconazole effects do not change at some arbitrary point in the future untill it is shown that this does infact happen.

Either way I completely agree with your assessment. Its generally always a good rule to start small and work your way up. This way you can pace yourself for several years of fighting hair loss, without dumping everything on at once, and running out of options in a shorter time.

HairLossTalk.com

I have always had a little trouble understanding this approach, not to say it is wrong, it may be the right way to do things.

With regard to inhibiting DHT, hitting it with everything as soon as possible (within reason, age etc) is the most logical option, there is little reason to let your follicles become somewhat damaged because you are saving up a complete protection for when this damage starts to become apparent.

The idea of holding off on minoxidil may have some legitimacy, although I fail to see it clearly.