the only reason why duta is more affective than propecia is becuase it inhibits more of the alpha type 2. plus alot of doctors still say there isn't even evidence to even show duta is more effective. it might be just the same, or just slightly better. if duta was in fact better, than glaxo would of pursued an fda approval by now, so they can make millions. not because of its alpha type 1 inhibition abilities. type 1 does not cause hairloss. the psudeohermaphordites had type 1 alpha 5 reductase with normal testosterone levels as well, and never expereinced hairloss due to the, not having the type 2 enzyme.
again in terms of spironolactone. spironolactone only inhibits testosterone, not alpha 5 reducatse type 2. even on spironolactone there will be little testosterone that will bind with the type 2 reducatse enzyme that will produce DHT, and more hairloss. thats why finasteride is way better than spironolactone because it tackles the root source wich is the type 2 enzyme.
plus guys should not be taking spironolactone due to the massive side affects. its given to transgenders lol