Do Hair Follicles Die Due To Male Pattern Baldness?

[New dimonesion]

I have been pondering whether hair follicles, die out due to male pattern baldness or just remain miniaturized and producing tiny microscopic hairs undetectable to the human eye.

Can anyone provide some info pls?

 

[lemoncloak]

I have been pondering whether hair follicles, die out due to male pattern baldness or just remain miniaturized and producing tiny microscopic hairs undetectable to the human eye.

Can anyone provide some info pls?

They become dormant and still produce vellus hair, but they don't cycle. Dermal papilla cells, one of the two cell populations that cooperate to generate hairs, eventually gets destroyed by Androgenetic Alopecia, while the other cells, epithelial stem cells residing in the bulge of the follicle (these also migrate downwards to form the hair germ in the beginning of anagen and later the hair shaft, after cooperation with the dermal papilla) don't get destroyed but become dormant instead. That is, they stop dividing and just sit there.
Unfortunately, you can't grow hair without dermal papillas so regrowing vellus hairs with medicine is most likely 100% impossible. You need to repopulate the follicle with healthy dermal papillas cells to get it to grow again. Several cell therapies are on r&d timelines right now across the globe.

 

[Trichosan]

Hair biology is fascinating science. You can even get some HFDPCs here:

https://www.cellapplications.com/human-hair-follicle-dermal-papilla-cells-hfdpc

Watch them grow, talk to them, keep them as pets. Just can't use 'em...yet

 

[New dimonesion]

They become dormant and still produce vellus hair, but they don't cycle. Dermal papilla cells, one of the two cell populations that cooperate to generate hairs, eventually gets destroyed by Androgenetic Alopecia, while the other cells, epithelial stem cells residing in the bulge of the follicle (these also migrate downwards to form the hair germ in the beginning of anagen and later the hair shaft, after cooperation with the dermal papilla) don't get destroyed but become dormant instead. That is, they stop dividing and just sit there.
Unfortunately, you can't grow hair without dermal papillas so regrowing vellus hairs with medicine is most likely 100% impossible. You need to repopulate the follicle with healthy dermal papillas cells to get it to grow again. Several cell therapies are on r&d timelines right now across the globe.

Thanks for the detailed info.

Could you kindly mention the companies involved with dermal papillae regeneration, or something of the sort?

Also, would JAK inhibitors effect dermal papillae?

 

[New dimonesion]

Hair biology is fascinating science. You can even get some HFDPCs here:

https://www.cellapplications.com/human-hair-follicle-dermal-papilla-cells-hfdpc

Watch them grow, talk to them, keep them as pets. Just can't use 'em...yet

Basically, we could farm them, but get no hair in return

 

[lemoncloak]

Thanks for the detailed info.

Could you kindly mention the companies involved with dermal papillae regeneration, or something of the sort?

Also, would JAK inhibitors effect dermal papillae?

1. Riken & organ technologies & kyocera
2. Shiseido
3. Replicel
4. Tissuse
5. Dr Alexey Terskikh
6. Hairclone
7. PolarityTE (just heard of this one)
8. Rapunzel (angela christiano's, think it's not active yet)
9. L'Oreal
The first 5 have showed some progress so far. Not all methods are the same.
As for jak... I don't know.. But tbh it's very unlikely they'll work for long gone hair. That's the general concensus in the forums, as well as Cotsarelis's opinion. Personally I don't expect anything from jak. Also note that it was tested on a guy with Androgenetic Alopecia and areata. It cured his areata but not his baldness so...

 

[New dimonesion]

1. Riken & organ technologies & kyocera
2. Shiseido
3. Replicel
4. Tissuse
5. Dr Alexey Terskikh
6. Hairclone
7. PolarityTE (just heard of this one)
8. Rapunzel (angela christiano's, think it's not active yet)
9. L'Oreal
The first 5 have showed some progress so far. Not all methods are the same.
As for jak... I don't know.. But tbh it's very unlikely they'll work for long gone hair. That's the general concensus in the forums, as well as Cotsarelis's opinion. Personally I don't expect anything from jak

Thanks again for the info.

TBH, when it comes to JAK, I have some hope because somehow during the interviews, both Angela Christiano and Aclaris CEO DR Neil Walker have made some slip ups with regards to male pattern baldness.

 

[lemoncloak]

Thanks again for the info.

TBH, when it comes to JAK, I have some hope because somehow during the interviews, both Angela Christiano and Aclaris CEO DR Neil Walker have made some slip ups with regards to male pattern baldness.

Check out my edit. And ur welcome