do follicles really die?

[Armando Jose]

we are the naked ape, but with all skin covered by pilosebaceous units, hair, in some areas minituariced.
What we think about these tiny hairs, are important for us? Sometimes are invisibles to us, but they are and exists.
Is it this same mechanims with hairloss? The miniaturization ? or the inhabilty to create a new hair?
A question, is the same lenght of the hairs cycles comparing terminal, pigmented with tiny hairs? heva the same numbres of hair's cycles?

 

[Mikazz]

We know that follicles don't dispear, they simply stop working after becoming really small.

We don't know a lot more and we can only make hypothesis. I have done a lot of research reading various papers, publications and patents and I can say that baldness have a lot in common with premature aging(located in the follicles). Aging is a sickiness and the FDA won't recognized that so they won't allow budgets to research anti-aging stuff which is a shame.

However, there is some other sickness that is caused by premature aging and they share A LOT in common with baldness. They are alzheimer and parckinson, and I have seen some people regrowing hairs while being under experimental treatment of parkinson or alzheimer.

 

[abcdefg]

If male pattern baldness is related to premature aging though why do men with strong histories lose it and men without not? Aging as a process doesnt really skip over people but male pattern baldness certainly does. I still think potent castration type AAs are capable of stopping male pattern baldness completely. I guess androgens probably arent the root cause though just a superficial thing we have found so far. Kind of like how we used to think protons and neutrons were the smallest pieces of matter when in fact its much more complex.

 

[Mikazz]

If male pattern baldness is related to premature aging though why do men with strong histories lose it and men without not? Aging as a process doesnt really skip over people but male pattern baldness certainly does. I still think potent castration type AAs are capable of stopping male pattern baldness completely. I guess androgens probably arent the root cause though just a superficial thing we have found so far. Kind of like how we used to think protons and neutrons were the smallest pieces of matter when in fact its much more complex.

At the follicle level, high DHT exposure cause a high oxidative stress which causes premature aging of the dermal papilla trough sensescence.

Look at this one: Androgen Receptor Accelerates Premature Senescence of Human Dermal Papilla Cells in Association with DNA Damage